@misc{repa_a._smoflipid_2016,
	title = {Smoflipid for prevention of parenteral nutrition associated cholestasis in elbwinfants},
	abstract = {Background and aims Preterm infants with extremely low birth weight (ELBW) are at increased risk of developing parenteral nutrition-associated cholestasis (PNAC). Fat emulsions containing fish oil are used in the treatment of PNAC. Whether PNACcan be prevented by primary use of fish oil containing fat emulsion for parenteral nutrition is little studied. In this study, we investigated to what extent fish oil containing lipid emulsion (SMOFlipid, SMOF) reduces the incidence of PNAC in ELBW preterm infants compared to a fat emulsion based on soybean oil (Intralipid, IL). Methods In this single-center prospective, randomized, double blind study either Intralipid or SMOFlipid was used for parenteral nutrition in ELBW infants. The primary outcome was PNAC (conjugated bilirubin {\textgreater} 1.5 mg/dl in two consecutive measurements during hospital stay). Results A total of 230 children were included and 207 infants were analyzed (IL: n=101, SMOF: n=106). The demographic parameters were evenly distributed between the two groups. PNAC incidence was 11.3\% in the SMOF group and 14.9\% in the IL group, which was not statistically significant (p=0.451). There were no differences in the incidence of morbidities associated with extreme prematurity such as ROP, culture proven sepsis or NEC. Conclusions The use of a fish oil containing fat emulsion (SMOFlipid) had no protective effect on PNAC incidence in ELBW infants at our center, with a generally low incidence of PNAC. Our data did not show any effect on ROP or sepsis.},
	journal = {European Journal of Pediatrics},
	author = {{Repa A.} and {Binder C.} and {Thanhaeuser M.} and {Kreissl A.} and {Dangl M.} and {Berger A.} and {Haiden N.}},
	year = {2016},
	keywords = {*cholestasis, *parenteral nutrition, Fish oil, Soybean oil, bilirubin glucuronide, clinical trial, controlled clinical trial, controlled study, double blind procedure, emulsion, extremely low birth weight, hospitalization, human, infant, lipid emulsion, major clinical study, morbidity, prematurity, prevention, randomized controlled trial, sepsis}
}

{"_id":"7NQWFTgjWHmgRtBFJ","bibbaseid":"repaa-binderc-thanhaeuserm-kreissla-danglm-bergera-haidenn-smoflipidforpreventionofparenteralnutritionassociatedcholestasisinelbwinfants-2016","downloads":0,"creationDate":"2017-05-12T20:20:57.527Z","title":"Smoflipid for prevention of parenteral nutrition associated cholestasis in elbwinfants","author_short":["Repa A.","Binder C.","Thanhaeuser M.","Kreissl A.","Dangl M.","Berger A.","Haiden N."],"year":2016,"bibtype":"misc","biburl":"http://bibbase.org/zotero/gxu917","bibdata":{"bibtype":"misc","type":"misc","title":"Smoflipid for prevention of parenteral nutrition associated cholestasis in elbwinfants","abstract":"Background and aims Preterm infants with extremely low birth weight (ELBW) are at increased risk of developing parenteral nutrition-associated cholestasis (PNAC). Fat emulsions containing fish oil are used in the treatment of PNAC. Whether PNACcan be prevented by primary use of fish oil containing fat emulsion for parenteral nutrition is little studied. In this study, we investigated to what extent fish oil containing lipid emulsion (SMOFlipid, SMOF) reduces the incidence of PNAC in ELBW preterm infants compared to a fat emulsion based on soybean oil (Intralipid, IL). Methods In this single-center prospective, randomized, double blind study either Intralipid or SMOFlipid was used for parenteral nutrition in ELBW infants. The primary outcome was PNAC (conjugated bilirubin \\textgreater 1.5 mg/dl in two consecutive measurements during hospital stay). Results A total of 230 children were included and 207 infants were analyzed (IL: n=101, SMOF: n=106). The demographic parameters were evenly distributed between the two groups. PNAC incidence was 11.3% in the SMOF group and 14.9% in the IL group, which was not statistically significant (p=0.451). There were no differences in the incidence of morbidities associated with extreme prematurity such as ROP, culture proven sepsis or NEC. Conclusions The use of a fish oil containing fat emulsion (SMOFlipid) had no protective effect on PNAC incidence in ELBW infants at our center, with a generally low incidence of PNAC. Our data did not show any effect on ROP or sepsis.","journal":"European Journal of Pediatrics","author":[{"firstnames":[],"propositions":[],"lastnames":["Repa A."],"suffixes":[]},{"firstnames":[],"propositions":[],"lastnames":["Binder C."],"suffixes":[]},{"firstnames":[],"propositions":[],"lastnames":["Thanhaeuser M."],"suffixes":[]},{"firstnames":[],"propositions":[],"lastnames":["Kreissl A."],"suffixes":[]},{"firstnames":[],"propositions":[],"lastnames":["Dangl M."],"suffixes":[]},{"firstnames":[],"propositions":[],"lastnames":["Berger A."],"suffixes":[]},{"firstnames":[],"propositions":[],"lastnames":["Haiden N."],"suffixes":[]}],"year":"2016","keywords":"*cholestasis, *parenteral nutrition, Fish oil, Soybean oil, bilirubin glucuronide, clinical trial, controlled clinical trial, controlled study, double blind procedure, emulsion, extremely low birth weight, hospitalization, human, infant, lipid emulsion, major clinical study, morbidity, prematurity, prevention, randomized controlled trial, sepsis","bibtex":"@misc{repa_a._smoflipid_2016,\n\ttitle = {Smoflipid for prevention of parenteral nutrition associated cholestasis in elbwinfants},\n\tabstract = {Background and aims Preterm infants with extremely low birth weight (ELBW) are at increased risk of developing parenteral nutrition-associated cholestasis (PNAC). Fat emulsions containing fish oil are used in the treatment of PNAC. Whether PNACcan be prevented by primary use of fish oil containing fat emulsion for parenteral nutrition is little studied. In this study, we investigated to what extent fish oil containing lipid emulsion (SMOFlipid, SMOF) reduces the incidence of PNAC in ELBW preterm infants compared to a fat emulsion based on soybean oil (Intralipid, IL). Methods In this single-center prospective, randomized, double blind study either Intralipid or SMOFlipid was used for parenteral nutrition in ELBW infants. The primary outcome was PNAC (conjugated bilirubin {\\textgreater} 1.5 mg/dl in two consecutive measurements during hospital stay). Results A total of 230 children were included and 207 infants were analyzed (IL: n=101, SMOF: n=106). The demographic parameters were evenly distributed between the two groups. PNAC incidence was 11.3\\% in the SMOF group and 14.9\\% in the IL group, which was not statistically significant (p=0.451). There were no differences in the incidence of morbidities associated with extreme prematurity such as ROP, culture proven sepsis or NEC. Conclusions The use of a fish oil containing fat emulsion (SMOFlipid) had no protective effect on PNAC incidence in ELBW infants at our center, with a generally low incidence of PNAC. Our data did not show any effect on ROP or sepsis.},\n\tjournal = {European Journal of Pediatrics},\n\tauthor = {{Repa A.} and {Binder C.} and {Thanhaeuser M.} and {Kreissl A.} and {Dangl M.} and {Berger A.} and {Haiden N.}},\n\tyear = {2016},\n\tkeywords = {*cholestasis, *parenteral nutrition, Fish oil, Soybean oil, bilirubin glucuronide, clinical trial, controlled clinical trial, controlled study, double blind procedure, emulsion, extremely low birth weight, hospitalization, human, infant, lipid emulsion, major clinical study, morbidity, prematurity, prevention, randomized controlled trial, sepsis}\n}\n\n","author_short":["Repa A.","Binder C.","Thanhaeuser M.","Kreissl A.","Dangl M.","Berger A.","Haiden N."],"key":"repa_a._smoflipid_2016","id":"repa_a._smoflipid_2016","bibbaseid":"repaa-binderc-thanhaeuserm-kreissla-danglm-bergera-haidenn-smoflipidforpreventionofparenteralnutritionassociatedcholestasisinelbwinfants-2016","role":"author","urls":{},"keyword":["*cholestasis","*parenteral nutrition","Fish oil","Soybean oil","bilirubin glucuronide","clinical trial","controlled clinical trial","controlled study","double blind procedure","emulsion","extremely low birth weight","hospitalization","human","infant","lipid emulsion","major clinical study","morbidity","prematurity","prevention","randomized controlled trial","sepsis"],"downloads":0,"html":""},"search_terms":["smoflipid","prevention","parenteral","nutrition","associated","cholestasis","elbwinfants","repa a.","binder c.","thanhaeuser m.","kreissl a.","dangl m.","berger a.","haiden n."],"keywords":["*cholestasis","*parenteral nutrition","fish oil","soybean oil","bilirubin glucuronide","clinical trial","controlled clinical trial","controlled study","double blind procedure","emulsion","extremely low birth weight","hospitalization","human","infant","lipid emulsion","major clinical study","morbidity","prematurity","prevention","randomized controlled trial","sepsis"],"authorIDs":[],"dataSources":["9LqPNaySNpNxYBFzj"]}