@article{
 title = {Strong expression of interleukin-17 is associated with higher histologic grades in canine mammary carcinoma},
 type = {article},
 year = {2017},
 identifiers = {[object Object]},
 keywords = {Canine mammary tumour,Histologic grade,Immunohistochemistry,Interleukin-17,Recurrence},
 volume = {26},
 id = {d3fedcd2-ff1a-3188-80be-383f8e1c0e60},
 created = {2017-12-07T02:33:15.189Z},
 file_attached = {false},
 profile_id = {e9b46c65-2d6e-3a2e-94da-5aeed120bcbb},
 last_modified = {2017-12-07T02:33:15.189Z},
 read = {false},
 starred = {false},
 authored = {true},
 confirmed = {false},
 hidden = {false},
 private_publication = {false},
 abstract = {© 2017, Springer-Verlag London. Mammary tumours are considered as an important health problem in female dogs and because of its numerous common characteristics with human breast cancer, it can be used as a good model for breast cancer studies. Interleukin-17 is a pro-inflammatory cytokine which is mainly secreted by activated Th-17 cells. There are evidences suggesting that interleukin-17 can be produced by various types of tumour cells and tumour-associated inflammatory cells. It also plays important roles in carcinogenesis by having both anti-tumour and pro-tumour functions. This study investigates interleukin-17 expression in canine mammary tumours by immunohistochemistry and its relationships with histologic grades, tumour recurrence and survival after 2 years. Results showed that 23 samples (63.88%) showed strong immunoreactivity for interleukin-17 and 13 samples (36.11%) showed moderate immunoreactivity. Interleukin-17 expression is significantly increased in canine mammary tumours compared to normal canine mammary tissues (P  <  0.05). Furthermore, our results showed that interleukin-17 increased expression is significantly associated with high histologic grade (P  <  0.05). Interleukin-17 may be involved in pathogenesis of canine mammary tumours by promoting malignancy grades; however, more investigations are needed to clarify this idea.},
 bibtype = {article},
 author = {Rezaee, M. and Movassaghi, A.R. and Dehghani, H.},
 journal = {Comparative Clinical Pathology},
 number = {2}
}

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Mammary tumours are considered as an important health problem in female dogs and because of its numerous common characteristics with human breast cancer, it can be used as a good model for breast cancer studies. Interleukin-17 is a pro-inflammatory cytokine which is mainly secreted by activated Th-17 cells. There are evidences suggesting that interleukin-17 can be produced by various types of tumour cells and tumour-associated inflammatory cells. It also plays important roles in carcinogenesis by having both anti-tumour and pro-tumour functions. This study investigates interleukin-17 expression in canine mammary tumours by immunohistochemistry and its relationships with histologic grades, tumour recurrence and survival after 2 years. Results showed that 23 samples (63.88%) showed strong immunoreactivity for interleukin-17 and 13 samples (36.11%) showed moderate immunoreactivity. Interleukin-17 expression is significantly increased in canine mammary tumours compared to normal canine mammary tissues (P  <  0.05). Furthermore, our results showed that interleukin-17 increased expression is significantly associated with high histologic grade (P  <  0.05). Interleukin-17 may be involved in pathogenesis of canine mammary tumours by promoting malignancy grades; however, more investigations are needed to clarify this idea.","bibtype":"article","author":"Rezaee, M. and Movassaghi, A.R. and Dehghani, H.","journal":"Comparative Clinical Pathology","number":"2","bibtex":"@article{\n title = {Strong expression of interleukin-17 is associated with higher histologic grades in canine mammary carcinoma},\n type = {article},\n year = {2017},\n identifiers = {[object Object]},\n keywords = {Canine mammary tumour,Histologic grade,Immunohistochemistry,Interleukin-17,Recurrence},\n volume = {26},\n id = {d3fedcd2-ff1a-3188-80be-383f8e1c0e60},\n created = {2017-12-07T02:33:15.189Z},\n file_attached = {false},\n profile_id = {e9b46c65-2d6e-3a2e-94da-5aeed120bcbb},\n last_modified = {2017-12-07T02:33:15.189Z},\n read = {false},\n starred = {false},\n authored = {true},\n confirmed = {false},\n hidden = {false},\n private_publication = {false},\n abstract = {© 2017, Springer-Verlag London. 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Interleukin-17 expression is significantly increased in canine mammary tumours compared to normal canine mammary tissues (P  <  0.05). Furthermore, our results showed that interleukin-17 increased expression is significantly associated with high histologic grade (P  <  0.05). 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