Plasmon-mediated cancer phototherapy: The combined effect of thermal and photodynamic processes. Ricciardi, L., Sancey, L., Palermo, G., Termine, R., De Luca, A., Szerb, E., Aiello, I., Ghedini, M., Strangi, G., & La Deda, M. Nanoscale, 9(48):19279-19289, Royal Society of Chemistry, 2017. cited By 18
Paper doi abstract bibtex A nanoplatform for simultaneous cellular imaging, and photodynamic and photothermal therapies has been designed and realized by embedding a purposely synthesized highly luminescent water soluble iridium(iii) compound into gold core-silica shell nanoparticles. These multifunctionalities arise mainly from the photophysical properties of the cyclometalated complex: (i) the heavy atom promotes, through excited triplet state formation, energy transfer processes towards molecular oxygen, with the generation of 1O2 (photodynamic effect); (ii) the overlap of the iridium(iii) complex emission band with the plasmonic resonance of gold nanostructures allows excitation energy transfer towards the metallic core (photothermal effect); (iii) the remarkable iridium(iii) complex luminescence feature, which is preserved despite energy transfer processes, makes the whole system an efficient luminescent bio-probe (imaging). Photophysical and photothermal investigations have been carried out, whereas in vitro photo-cytotoxicity tests have been performed on human glioblastoma cells (U87MG), highlighting significant cancer cell death at a very low photosensitizer concentration (<0.5 μM), by means of a synergistic photodynamic and photothermal effect. © 2017 The Royal Society of Chemistry.
@ARTICLE{Ricciardi201719279,
author={Ricciardi, L. and Sancey, L. and Palermo, G. and Termine, R. and De Luca, A. and Szerb, E.I. and Aiello, I. and Ghedini, M. and Strangi, G. and La Deda, M.},
title={Plasmon-mediated cancer phototherapy: The combined effect of thermal and photodynamic processes},
journal={Nanoscale},
year={2017},
volume={9},
number={48},
pages={19279-19289},
doi={10.1039/c7nr05522f},
note={cited By 18},
url={https://www.scopus.com/inward/record.uri?eid=2-s2.0-85038447428&doi=10.1039%2fc7nr05522f&partnerID=40&md5=5b1b767600373401daae3f8fbc0f522b},
abstract={A nanoplatform for simultaneous cellular imaging, and photodynamic and photothermal therapies has been designed and realized by embedding a purposely synthesized highly luminescent water soluble iridium(iii) compound into gold core-silica shell nanoparticles. These multifunctionalities arise mainly from the photophysical properties of the cyclometalated complex: (i) the heavy atom promotes, through excited triplet state formation, energy transfer processes towards molecular oxygen, with the generation of 1O2 (photodynamic effect); (ii) the overlap of the iridium(iii) complex emission band with the plasmonic resonance of gold nanostructures allows excitation energy transfer towards the metallic core (photothermal effect); (iii) the remarkable iridium(iii) complex luminescence feature, which is preserved despite energy transfer processes, makes the whole system an efficient luminescent bio-probe (imaging). Photophysical and photothermal investigations have been carried out, whereas in vitro photo-cytotoxicity tests have been performed on human glioblastoma cells (U87MG), highlighting significant cancer cell death at a very low photosensitizer concentration (<0.5 μM), by means of a synergistic photodynamic and photothermal effect. © 2017 The Royal Society of Chemistry.},
publisher={Royal Society of Chemistry},
issn={20403364},
pubmed_id={29189851},
document_type={Article},
source={Scopus},
}
Downloads: 0
{"_id":"fDdTnCJavyxWdwxXL","bibbaseid":"ricciardi-sancey-palermo-termine-deluca-szerb-aiello-ghedini-etal-plasmonmediatedcancerphototherapythecombinedeffectofthermalandphotodynamicprocesses-2017","authorIDs":[],"author_short":["Ricciardi, L.","Sancey, L.","Palermo, G.","Termine, R.","De Luca, A.","Szerb, E.","Aiello, I.","Ghedini, M.","Strangi, G.","La Deda, M."],"bibdata":{"bibtype":"article","type":"article","author":[{"propositions":[],"lastnames":["Ricciardi"],"firstnames":["L."],"suffixes":[]},{"propositions":[],"lastnames":["Sancey"],"firstnames":["L."],"suffixes":[]},{"propositions":[],"lastnames":["Palermo"],"firstnames":["G."],"suffixes":[]},{"propositions":[],"lastnames":["Termine"],"firstnames":["R."],"suffixes":[]},{"propositions":[],"lastnames":["De","Luca"],"firstnames":["A."],"suffixes":[]},{"propositions":[],"lastnames":["Szerb"],"firstnames":["E.I."],"suffixes":[]},{"propositions":[],"lastnames":["Aiello"],"firstnames":["I."],"suffixes":[]},{"propositions":[],"lastnames":["Ghedini"],"firstnames":["M."],"suffixes":[]},{"propositions":[],"lastnames":["Strangi"],"firstnames":["G."],"suffixes":[]},{"propositions":[],"lastnames":["La","Deda"],"firstnames":["M."],"suffixes":[]}],"title":"Plasmon-mediated cancer phototherapy: The combined effect of thermal and photodynamic processes","journal":"Nanoscale","year":"2017","volume":"9","number":"48","pages":"19279-19289","doi":"10.1039/c7nr05522f","note":"cited By 18","url":"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85038447428&doi=10.1039%2fc7nr05522f&partnerID=40&md5=5b1b767600373401daae3f8fbc0f522b","abstract":"A nanoplatform for simultaneous cellular imaging, and photodynamic and photothermal therapies has been designed and realized by embedding a purposely synthesized highly luminescent water soluble iridium(iii) compound into gold core-silica shell nanoparticles. These multifunctionalities arise mainly from the photophysical properties of the cyclometalated complex: (i) the heavy atom promotes, through excited triplet state formation, energy transfer processes towards molecular oxygen, with the generation of 1O2 (photodynamic effect); (ii) the overlap of the iridium(iii) complex emission band with the plasmonic resonance of gold nanostructures allows excitation energy transfer towards the metallic core (photothermal effect); (iii) the remarkable iridium(iii) complex luminescence feature, which is preserved despite energy transfer processes, makes the whole system an efficient luminescent bio-probe (imaging). Photophysical and photothermal investigations have been carried out, whereas in vitro photo-cytotoxicity tests have been performed on human glioblastoma cells (U87MG), highlighting significant cancer cell death at a very low photosensitizer concentration (<0.5 μM), by means of a synergistic photodynamic and photothermal effect. © 2017 The Royal Society of Chemistry.","publisher":"Royal Society of Chemistry","issn":"20403364","pubmed_id":"29189851","document_type":"Article","source":"Scopus","bibtex":"@ARTICLE{Ricciardi201719279,\nauthor={Ricciardi, L. and Sancey, L. and Palermo, G. and Termine, R. and De Luca, A. and Szerb, E.I. and Aiello, I. and Ghedini, M. and Strangi, G. and La Deda, M.},\ntitle={Plasmon-mediated cancer phototherapy: The combined effect of thermal and photodynamic processes},\njournal={Nanoscale},\nyear={2017},\nvolume={9},\nnumber={48},\npages={19279-19289},\ndoi={10.1039/c7nr05522f},\nnote={cited By 18},\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-85038447428&doi=10.1039%2fc7nr05522f&partnerID=40&md5=5b1b767600373401daae3f8fbc0f522b},\nabstract={A nanoplatform for simultaneous cellular imaging, and photodynamic and photothermal therapies has been designed and realized by embedding a purposely synthesized highly luminescent water soluble iridium(iii) compound into gold core-silica shell nanoparticles. These multifunctionalities arise mainly from the photophysical properties of the cyclometalated complex: (i) the heavy atom promotes, through excited triplet state formation, energy transfer processes towards molecular oxygen, with the generation of 1O2 (photodynamic effect); (ii) the overlap of the iridium(iii) complex emission band with the plasmonic resonance of gold nanostructures allows excitation energy transfer towards the metallic core (photothermal effect); (iii) the remarkable iridium(iii) complex luminescence feature, which is preserved despite energy transfer processes, makes the whole system an efficient luminescent bio-probe (imaging). Photophysical and photothermal investigations have been carried out, whereas in vitro photo-cytotoxicity tests have been performed on human glioblastoma cells (U87MG), highlighting significant cancer cell death at a very low photosensitizer concentration (<0.5 μM), by means of a synergistic photodynamic and photothermal effect. © 2017 The Royal Society of Chemistry.},\npublisher={Royal Society of Chemistry},\nissn={20403364},\npubmed_id={29189851},\ndocument_type={Article},\nsource={Scopus},\n}\n\n","author_short":["Ricciardi, L.","Sancey, L.","Palermo, G.","Termine, R.","De Luca, A.","Szerb, E.","Aiello, I.","Ghedini, M.","Strangi, G.","La Deda, M."],"key":"Ricciardi201719279","id":"Ricciardi201719279","bibbaseid":"ricciardi-sancey-palermo-termine-deluca-szerb-aiello-ghedini-etal-plasmonmediatedcancerphototherapythecombinedeffectofthermalandphotodynamicprocesses-2017","role":"author","urls":{"Paper":"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85038447428&doi=10.1039%2fc7nr05522f&partnerID=40&md5=5b1b767600373401daae3f8fbc0f522b"},"metadata":{"authorlinks":{}},"downloads":0,"html":""},"bibtype":"article","biburl":"http://nanotec.cnr.it/data/nanotec/scopus-2017.bib","creationDate":"2020-04-27T18:01:50.793Z","downloads":0,"keywords":[],"search_terms":["plasmon","mediated","cancer","phototherapy","combined","effect","thermal","photodynamic","processes","ricciardi","sancey","palermo","termine","de luca","szerb","aiello","ghedini","strangi","la deda"],"title":"Plasmon-mediated cancer phototherapy: The combined effect of thermal and photodynamic processes","year":2017,"dataSources":["TgRzGSnFk8ZF7cwa2","ETQm4KuYrrdfxXLmt","Xwr3Ky8YCPtt2S7S2"]}