Plasmon-mediated cancer phototherapy: The combined effect of thermal and photodynamic processes. Ricciardi, L., Sancey, L., Palermo, G., Termine, R., De Luca, A., Szerb, E., Aiello, I., Ghedini, M., Strangi, G., & La Deda, M. Nanoscale, 9(48):19279-19289, Royal Society of Chemistry, 2017. cited By 18
Plasmon-mediated cancer phototherapy: The combined effect of thermal and photodynamic processes [link]Paper  doi  abstract   bibtex   
A nanoplatform for simultaneous cellular imaging, and photodynamic and photothermal therapies has been designed and realized by embedding a purposely synthesized highly luminescent water soluble iridium(iii) compound into gold core-silica shell nanoparticles. These multifunctionalities arise mainly from the photophysical properties of the cyclometalated complex: (i) the heavy atom promotes, through excited triplet state formation, energy transfer processes towards molecular oxygen, with the generation of 1O2 (photodynamic effect); (ii) the overlap of the iridium(iii) complex emission band with the plasmonic resonance of gold nanostructures allows excitation energy transfer towards the metallic core (photothermal effect); (iii) the remarkable iridium(iii) complex luminescence feature, which is preserved despite energy transfer processes, makes the whole system an efficient luminescent bio-probe (imaging). Photophysical and photothermal investigations have been carried out, whereas in vitro photo-cytotoxicity tests have been performed on human glioblastoma cells (U87MG), highlighting significant cancer cell death at a very low photosensitizer concentration (<0.5 μM), by means of a synergistic photodynamic and photothermal effect. © 2017 The Royal Society of Chemistry.
@ARTICLE{Ricciardi201719279,
author={Ricciardi, L. and Sancey, L. and Palermo, G. and Termine, R. and De Luca, A. and Szerb, E.I. and Aiello, I. and Ghedini, M. and Strangi, G. and La Deda, M.},
title={Plasmon-mediated cancer phototherapy: The combined effect of thermal and photodynamic processes},
journal={Nanoscale},
year={2017},
volume={9},
number={48},
pages={19279-19289},
doi={10.1039/c7nr05522f},
note={cited By 18},
url={https://www.scopus.com/inward/record.uri?eid=2-s2.0-85038447428&doi=10.1039%2fc7nr05522f&partnerID=40&md5=5b1b767600373401daae3f8fbc0f522b},
abstract={A nanoplatform for simultaneous cellular imaging, and photodynamic and photothermal therapies has been designed and realized by embedding a purposely synthesized highly luminescent water soluble iridium(iii) compound into gold core-silica shell nanoparticles. These multifunctionalities arise mainly from the photophysical properties of the cyclometalated complex: (i) the heavy atom promotes, through excited triplet state formation, energy transfer processes towards molecular oxygen, with the generation of 1O2 (photodynamic effect); (ii) the overlap of the iridium(iii) complex emission band with the plasmonic resonance of gold nanostructures allows excitation energy transfer towards the metallic core (photothermal effect); (iii) the remarkable iridium(iii) complex luminescence feature, which is preserved despite energy transfer processes, makes the whole system an efficient luminescent bio-probe (imaging). Photophysical and photothermal investigations have been carried out, whereas in vitro photo-cytotoxicity tests have been performed on human glioblastoma cells (U87MG), highlighting significant cancer cell death at a very low photosensitizer concentration (&lt;0.5 μM), by means of a synergistic photodynamic and photothermal effect. © 2017 The Royal Society of Chemistry.},
publisher={Royal Society of Chemistry},
issn={20403364},
pubmed_id={29189851},
document_type={Article},
source={Scopus},
}

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