Aged garlic extract lowers blood pressure in patients with treated but uncontrolled hypertension: A randomised controlled trial. Ried, K., Frank, O. R., & Stocks, N. P. Maturitas, 67(2):144–150, October, 2010. Publisher: Elsevier![Aged garlic extract lowers blood pressure in patients with treated but uncontrolled hypertension: A randomised controlled trial [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex \textlessh2\textgreaterAbstract\textless/h2\textgreater\textlessh3\textgreaterObjective\textless/h3\textgreater\textlessp\textgreaterTo assess the effect, tolerability and acceptability of aged garlic extract as an adjunct treatment to existing antihypertensive medication in patients with treated, but uncontrolled, hypertension.\textless/p\textgreater\textlessh3\textgreaterDesign\textless/h3\textgreater\textlessp\textgreaterA double-blind parallel randomised placebo-controlled trial involving 50 patients whose routine clinical records in general practice documented treated but uncontrolled hypertension. The active treatment group received four capsules of aged garlic extract (960mg containing 2.4mg S-allylcysteine) daily for 12 weeks, and the control group received matching placebos. The primary outcome measures were systolic and diastolic blood pressure at baseline, 4, 8 and 12 weeks, and change over time. We also assessed tolerability during the trial and acceptability at 12 weeks.\textless/p\textgreater\textlessh3\textgreaterResults\textless/h3\textgreater\textlessp\textgreaterIn patients with uncontrolled hypertension (SBP≥140mmHg at baseline), systolic blood pressure was on average 10.2±4.3mmHg (p=0.03) lower in the garlic group compared with controls over the 12-week treatment period. Changes in blood pressure between the groups were not significant in patients with SBP\textless140mmHg at baseline. Aged garlic extract was generally well tolerated and acceptability of trial treatment was high (92%).\textless/p\textgreater\textlessh3\textgreaterConclusion\textless/h3\textgreater\textlessp\textgreaterOur trial suggests that aged garlic extract is superior to placebo in lowering systolic blood pressure similarly to current first line medications in patients with treated but uncontrolled hypertension.\textless/p\textgreater
@article{ried_aged_2010,
title = {Aged garlic extract lowers blood pressure in patients with treated but uncontrolled hypertension: {A} randomised controlled trial},
volume = {67},
issn = {0378-5122, 1873-4111},
shorttitle = {Aged garlic extract lowers blood pressure in patients with treated but uncontrolled hypertension},
url = {https://www.maturitas.org/article/S0378-5122(10)00227-6/abstract},
doi = {10.1016/j.maturitas.2010.06.001},
abstract = {{\textless}h2{\textgreater}Abstract{\textless}/h2{\textgreater}{\textless}h3{\textgreater}Objective{\textless}/h3{\textgreater}{\textless}p{\textgreater}To assess the effect, tolerability and acceptability of aged garlic extract as an adjunct treatment to existing antihypertensive medication in patients with treated, but uncontrolled, hypertension.{\textless}/p{\textgreater}{\textless}h3{\textgreater}Design{\textless}/h3{\textgreater}{\textless}p{\textgreater}A double-blind parallel randomised placebo-controlled trial involving 50 patients whose routine clinical records in general practice documented treated but uncontrolled hypertension. The active treatment group received four capsules of aged garlic extract (960mg containing 2.4mg S-allylcysteine) daily for 12 weeks, and the control group received matching placebos. The primary outcome measures were systolic and diastolic blood pressure at baseline, 4, 8 and 12 weeks, and change over time. We also assessed tolerability during the trial and acceptability at 12 weeks.{\textless}/p{\textgreater}{\textless}h3{\textgreater}Results{\textless}/h3{\textgreater}{\textless}p{\textgreater}In patients with uncontrolled hypertension (SBP≥140mmHg at baseline), systolic blood pressure was on average 10.2±4.3mmHg (\textit{p}=0.03) lower in the garlic group compared with controls over the 12-week treatment period. Changes in blood pressure between the groups were not significant in patients with SBP{\textless}140mmHg at baseline. Aged garlic extract was generally well tolerated and acceptability of trial treatment was high (92\%).{\textless}/p{\textgreater}{\textless}h3{\textgreater}Conclusion{\textless}/h3{\textgreater}{\textless}p{\textgreater}Our trial suggests that aged garlic extract is superior to placebo in lowering systolic blood pressure similarly to current first line medications in patients with treated but uncontrolled hypertension.{\textless}/p{\textgreater}},
language = {English},
number = {2},
urldate = {2020-05-18},
journal = {Maturitas},
author = {Ried, Karin and Frank, Oliver R. and Stocks, Nigel P.},
month = oct,
year = {2010},
pmid = {20594781},
note = {Publisher: Elsevier},
pages = {144--150},
}
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P."],"bibdata":{"bibtype":"article","type":"article","title":"Aged garlic extract lowers blood pressure in patients with treated but uncontrolled hypertension: A randomised controlled trial","volume":"67","issn":"0378-5122, 1873-4111","shorttitle":"Aged garlic extract lowers blood pressure in patients with treated but uncontrolled hypertension","url":"https://www.maturitas.org/article/S0378-5122(10)00227-6/abstract","doi":"10.1016/j.maturitas.2010.06.001","abstract":"\\textlessh2\\textgreaterAbstract\\textless/h2\\textgreater\\textlessh3\\textgreaterObjective\\textless/h3\\textgreater\\textlessp\\textgreaterTo assess the effect, tolerability and acceptability of aged garlic extract as an adjunct treatment to existing antihypertensive medication in patients with treated, but uncontrolled, hypertension.\\textless/p\\textgreater\\textlessh3\\textgreaterDesign\\textless/h3\\textgreater\\textlessp\\textgreaterA double-blind parallel randomised placebo-controlled trial involving 50 patients whose routine clinical records in general practice documented treated but uncontrolled hypertension. 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Aged garlic extract was generally well tolerated and acceptability of trial treatment was high (92%).\\textless/p\\textgreater\\textlessh3\\textgreaterConclusion\\textless/h3\\textgreater\\textlessp\\textgreaterOur trial suggests that aged garlic extract is superior to placebo in lowering systolic blood pressure similarly to current first line medications in patients with treated but uncontrolled hypertension.\\textless/p\\textgreater","language":"English","number":"2","urldate":"2020-05-18","journal":"Maturitas","author":[{"propositions":[],"lastnames":["Ried"],"firstnames":["Karin"],"suffixes":[]},{"propositions":[],"lastnames":["Frank"],"firstnames":["Oliver","R."],"suffixes":[]},{"propositions":[],"lastnames":["Stocks"],"firstnames":["Nigel","P."],"suffixes":[]}],"month":"October","year":"2010","pmid":"20594781","note":"Publisher: Elsevier","pages":"144–150","bibtex":"@article{ried_aged_2010,\n\ttitle = {Aged garlic extract lowers blood pressure in patients with treated but uncontrolled hypertension: {A} randomised controlled trial},\n\tvolume = {67},\n\tissn = {0378-5122, 1873-4111},\n\tshorttitle = {Aged garlic extract lowers blood pressure in patients with treated but uncontrolled hypertension},\n\turl = {https://www.maturitas.org/article/S0378-5122(10)00227-6/abstract},\n\tdoi = {10.1016/j.maturitas.2010.06.001},\n\tabstract = {{\\textless}h2{\\textgreater}Abstract{\\textless}/h2{\\textgreater}{\\textless}h3{\\textgreater}Objective{\\textless}/h3{\\textgreater}{\\textless}p{\\textgreater}To assess the effect, tolerability and acceptability of aged garlic extract as an adjunct treatment to existing antihypertensive medication in patients with treated, but uncontrolled, hypertension.{\\textless}/p{\\textgreater}{\\textless}h3{\\textgreater}Design{\\textless}/h3{\\textgreater}{\\textless}p{\\textgreater}A double-blind parallel randomised placebo-controlled trial involving 50 patients whose routine clinical records in general practice documented treated but uncontrolled hypertension. 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