Crystal Growth Inhibitors for the Prevention of l-Cystine Kidney Stones Through Molecular Design. Rimer, J., D., An, Z., Zhu, Z., Lee, M., H., Goldfarb, D., S., Wesson, J., A., & Ward, M., D. Science, 330(6002):337-341, American Association for the Advancement of Science, 2010. ![Crystal Growth Inhibitors for the Prevention of l-Cystine Kidney Stones Through Molecular Design [link]](https://bibbase.org/img/filetypes/link.svg "link")
Website abstract bibtex Crystallization of l-cystine is a critical step in the pathogenesis of cystine kidney stones. Treatments for this disease are somewhat effective but often lead to adverse side effects. Real-time in situ atomic force microscopy (AFM) reveals that l-cystine dimethylester (L-CDME) and l-cystine methylester (L-CME) dramatically reduce the growth velocity of the six symmetry-equivalent 100 steps because of specific binding at the crystal surface, which frustrates the attachment of l-cystine molecules. L-CDME and L-CME produce l-cystine crystals with different habits that reveal distinct binding modes at the crystal surfaces. The AFM observations are mirrored by reduced crystal yield and crystal size in the presence of L-CDME and L-CME, collectively suggesting a new pathway to the prevention of l-cystine stones by rational design of crystal growth inhibitors.
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title = {Crystal Growth Inhibitors for the Prevention of l-Cystine Kidney Stones Through Molecular Design},
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abstract = {Crystallization of l-cystine is a critical step in the pathogenesis of cystine kidney stones. Treatments for this disease are somewhat effective but often lead to adverse side effects. Real-time in situ atomic force microscopy (AFM) reveals that l-cystine dimethylester (L-CDME) and l-cystine methylester (L-CME) dramatically reduce the growth velocity of the six symmetry-equivalent 100 steps because of specific binding at the crystal surface, which frustrates the attachment of l-cystine molecules. L-CDME and L-CME produce l-cystine crystals with different habits that reveal distinct binding modes at the crystal surfaces. The AFM observations are mirrored by reduced crystal yield and crystal size in the presence of L-CDME and L-CME, collectively suggesting a new pathway to the prevention of l-cystine stones by rational design of crystal growth inhibitors.},
bibtype = {article},
author = {Rimer, Jeffrey D and An, Zhihua and Zhu, Zina and Lee, Michael H and Goldfarb, David S and Wesson, Jeffrey A and Ward, Michael D},
journal = {Science},
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