Derivation of a high-resolution CT-based, semi-automated radiographic score in tuberculosis and its relationship to bacillary load and antitubercular therapy. Riou, C., du Bruyn, E., Kim, G. H. J, da Costa, I., Lee, J., Sher, A., Wilkinson, R. J, Allwood, B. W, & Goldin, J. European Respiratory Journal, 62(3):2300600, European Respiratory Society, sep, 2023. ![Derivation of a high-resolution CT-based, semi-automated radiographic score in tuberculosis and its relationship to bacillary load and antitubercular therapy [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Efforts to curb the tuberculosis (TB) pandemic remain hindered by a lack of objective measures to quantify disease severity and track treatment success that are valid in both HIV-1-infected and -uninfected TB patients. Ralph et al. [1] developed a promising radiographic scoring system, with baseline scores being predictive of sputum smear conversion at 2 months, but it is reliant on skilled readers and has not been systematically validated in predominantly HIV-infected study populations with varying CD4 counts. Superior to conventional chest radiography, high-resolution computed tomography (HRCT) is a highly sensitive tool to track endobronchial TB disease extent [2]. A high-resolution CT based, semi-automated radiographic score correlates with Mycobacterium tuberculosis (Mtb) bacterial burden, peripheral monocyte count and the phenotypic profile of Mtb-specific CD4 T-cells, irrespective of HIV status \textlesshttps://bit.ly/44do4V6\textgreater We would like to thank all the study participants as well as Lorraine Brydon and her dedicated team of radiographers at Morton and Partners at Vincent Pallotti Hospital, Cape Town, South Africa.
@article{Riou2023,
abstract = {Efforts to curb the tuberculosis (TB) pandemic remain hindered by a lack of objective measures to quantify disease severity and track treatment success that are valid in both HIV-1-infected and -uninfected TB patients. Ralph et al. [1] developed a promising radiographic scoring system, with baseline scores being predictive of sputum smear conversion at 2 months, but it is reliant on skilled readers and has not been systematically validated in predominantly HIV-infected study populations with varying CD4 counts. Superior to conventional chest radiography, high-resolution computed tomography (HRCT) is a highly sensitive tool to track endobronchial TB disease extent [2]. A high-resolution CT based, semi-automated radiographic score correlates with Mycobacterium tuberculosis (Mtb) bacterial burden, peripheral monocyte count and the phenotypic profile of Mtb-specific CD4 T-cells, irrespective of HIV status {\textless}https://bit.ly/44do4V6{\textgreater} We would like to thank all the study participants as well as Lorraine Brydon and her dedicated team of radiographers at Morton and Partners at Vincent Pallotti Hospital, Cape Town, South Africa.},
author = {Riou, Catherine and du Bruyn, Elsa and Kim, Grace Hyun J and da Costa, Irene and Lee, Jihey and Sher, Alan and Wilkinson, Robert J and Allwood, Brian W and Goldin, Jonathan},
doi = {10.1183/13993003.00600-2023},
file = {:C$\backslash$:/Users/01462563/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Riou et al. - 2023 - Derivation of a high-resolution CT-based, semi-automated radiographic score in tuberculosis and its relationship to.pdf:pdf},
issn = {0903-1936},
journal = {European Respiratory Journal},
keywords = {OA,fund{\_}ack,letter},
mendeley-tags = {OA,fund{\_}ack,letter},
month = {sep},
number = {3},
pages = {2300600},
pmid = {37678952},
publisher = {European Respiratory Society},
title = {{Derivation of a high-resolution CT-based, semi-automated radiographic score in tuberculosis and its relationship to bacillary load and antitubercular therapy}},
url = {https://erj.ersjournals.com/content/62/3/2300600 https://erj.ersjournals.com/content/62/3/2300600.abstract},
volume = {62},
year = {2023}
}
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Superior to conventional chest radiography, high-resolution computed tomography (HRCT) is a highly sensitive tool to track endobronchial TB disease extent [2]. 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