Profile of SARS-CoV-2-specific CD4 T cell response: relationship with disease severity and impact of HIV-1 and active <i>Mycobacterium tuberculosis</i> co-infection. Riou, C., Du Bruyn, E., Stek, C., Daroowala, R., Goliath, R. T, Abrahams, F., Said-Hartley, Q., Allwood, B. W, Hsiao, M., Wilkinson, K. A, Lindestam Arlehamn, C. S, Sette, A., Wasserman, S., & Wilkinson, R. J medRxiv, Cold Spring Harbor Laboratory Press, feb, 2021. ![Profile of SARS-CoV-2-specific CD4 T cell response: relationship with disease severity and impact of HIV-1 and active <i>Mycobacterium tuberculosis</i> co-infection [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex T cells are involved in control of COVID-19, but limited knowledge is available on the relationship between antigen-specific T cell response and disease severity. Here, we assessed the magnitude, function and phenotype of SARS-CoV-2-specific CD4 T cells in 95 hospitalized COVID-19 patients (38 of them being HIV-1 and/or tuberculosis (TB) co-infected) and 38 non-COVID-19 patients, using flow cytometry. We showed that SARS-CoV-2-specific CD4 T cell attributes, rather than magnitude, associates with disease severity, with severe disease being characterized by poor polyfunctional potential, reduced proliferation capacity and enhanced HLA-DR expression. Moreover, HIV-1 and TB co-infection skewed the SARS-CoV-2 T cell response. HIV-1 mediated CD4 T cell depletion associated with suboptimal T cell and humoral immune responses to SARS-CoV-2; and a decrease in the polyfunctional capacity of SARS-CoV-2-specific CD4 T cells was observed in COVID-19 patients with active TB. Our results also revealed that COVID-19 patients displayed reduced frequency of Mtb-specific CD4 T cells, with possible implications for TB disease progression. There results corroborate the important role of SARS-CoV-2-specific T cells in COVID-19 pathogenesis and support the concept of altered T cell functions in patients with severe disease.
@article{CatherineRiou2021,
abstract = {T cells are involved in control of COVID-19, but limited knowledge is available on the relationship between antigen-specific T cell response and disease severity. Here, we assessed the magnitude, function and phenotype of SARS-CoV-2-specific CD4 T cells in 95 hospitalized COVID-19 patients (38 of them being HIV-1 and/or tuberculosis (TB) co-infected) and 38 non-COVID-19 patients, using flow cytometry. We showed that SARS-CoV-2-specific CD4 T cell attributes, rather than magnitude, associates with disease severity, with severe disease being characterized by poor polyfunctional potential, reduced proliferation capacity and enhanced HLA-DR expression. Moreover, HIV-1 and TB co-infection skewed the SARS-CoV-2 T cell response. HIV-1 mediated CD4 T cell depletion associated with suboptimal T cell and humoral immune responses to SARS-CoV-2; and a decrease in the polyfunctional capacity of SARS-CoV-2-specific CD4 T cells was observed in COVID-19 patients with active TB. Our results also revealed that COVID-19 patients displayed reduced frequency of Mtb-specific CD4 T cells, with possible implications for TB disease progression. There results corroborate the important role of SARS-CoV-2-specific T cells in COVID-19 pathogenesis and support the concept of altered T cell functions in patients with severe disease.},
author = {Riou, Catherine and {Du Bruyn}, Elsa and Stek, Cari and Daroowala, Remy and Goliath, Rene T and Abrahams, Fatima and Said-Hartley, Qonita and Allwood, Brian W and Hsiao, Marvin and Wilkinson, Katalin A and {Lindestam Arlehamn}, Cecilia S and Sette, Alessandro and Wasserman, Sean and Wilkinson, Robert J},
doi = {10.1101/2021.02.16.21251838},
file = {:C$\backslash$:/Users/01462563/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Riou et al. - 2021 - Profile of SARS-CoV-2-specific CD4 T cell response relationship with disease severity and impact of HIV-1 and activ.pdf:pdf},
journal = {medRxiv},
keywords = {COVID-19,HIV-1,OA,T cell response,TB,fund{\_}ack,original},
mendeley-tags = {OA,fund{\_}ack,original},
month = {feb},
pages = {2021.02.16.21251838},
publisher = {Cold Spring Harbor Laboratory Press},
title = {{Profile of SARS-CoV-2-specific CD4 T cell response: relationship with disease severity and impact of HIV-1 and active \textit{Mycobacterium tuberculosis} co-infection}},
url = {https://doi.org/10.1101/2021.02.16.21251838},
year = {2021}
}
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