Relationship of SARS-CoV-2-specific CD4 response to COVID-19 severity and impact of HIV-1 and tuberculosis co-infection. Riou, C., Du Bruyn, E., Stek, C., Daroowala, R., Goliath, R. T, Abrahams, F., Said-Hartley, Q., Allwood, B. W., Hsiao, N., Wilkinson, K. A., Lindestam Arlehamn, C. S., Sette, A., Wasserman, S., & Wilkinson, R. J Journal of Clinical Investigation, 131(12):e149125, American Society for Clinical Investigation, may, 2021. ![Relationship of SARS-CoV-2-specific CD4 response to COVID-19 severity and impact of HIV-1 and tuberculosis co-infection [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex 1 download ABSTRACT T cells are involved in control of COVID-19, but limited knowledge is available on the relationship between antigen-specific T cell response and disease severity. Here, we assessed the magnitude, function and phenotype of SARS-CoV-2-specific CD4 T cells in 95 hospitalized COVID-19 patients (38 of them being HIV-1 and/or tuberculosis (TB) co-infected) and 38 non-COVID-19 patients, using flow cytometry. We showed that SARS-CoV-2-specific CD4 T cell attributes, rather than magnitude, associates with disease severity, with severe disease being characterized by poor polyfunctional potential, reduced proliferation capacity and enhanced HLA-DR expression. Moreover, HIV-1 and TB co-infection skewed the SARS-CoV-2 T cell response. HIV-1 mediated CD4 T cell depletion associated with suboptimal T cell and humoral immune responses to SARS-CoV-2; and a decrease in the polyfunctional capacity of SARS-CoV-2-specific CD4 T cells was observed in COVID-19 patients with active TB. Our results also revealed that COVID-19 patients displayed reduced frequency of Mtb-specific CD4 T cells, with possible implications for TB disease progression.
@article{Riou2021,
abstract = {ABSTRACT T cells are involved in control of COVID-19, but limited knowledge is available on the relationship between antigen-specific T cell response and disease severity. Here, we assessed the magnitude, function and phenotype of SARS-CoV-2-specific CD4 T cells in 95 hospitalized COVID-19 patients (38 of them being HIV-1 and/or tuberculosis (TB) co-infected) and 38 non-COVID-19 patients, using flow cytometry. We showed that SARS-CoV-2-specific CD4 T cell attributes, rather than magnitude, associates with disease severity, with severe disease being characterized by poor polyfunctional potential, reduced proliferation capacity and enhanced HLA-DR expression. Moreover, HIV-1 and TB co-infection skewed the SARS-CoV-2 T cell response. HIV-1 mediated CD4 T cell depletion associated with suboptimal T cell and humoral immune responses to SARS-CoV-2; and a decrease in the polyfunctional capacity of SARS-CoV-2-specific CD4 T cells was observed in COVID-19 patients with active TB. Our results also revealed that COVID-19 patients displayed reduced frequency of Mtb-specific CD4 T cells, with possible implications for TB disease progression.},
author = {Riou, Catherine and {Du Bruyn}, Elsa and Stek, Cari and Daroowala, Remy and Goliath, Rene T and Abrahams, Fatima and Said-Hartley, Qonita and Allwood, Brian W. and Hsiao, Nei-Yuan and Wilkinson, Katalin A. and {Lindestam Arlehamn}, Cecilia S. and Sette, Alessandro and Wasserman, Sean and Wilkinson, Robert J},
doi = {10.1172/JCI149125},
file = {:C$\backslash$:/Users/01462563/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Riou et al. - 2021 - Relationship of SARS-CoV-2-specific CD4 response to COVID-19 severity and impact of HIV-1 and tuberculosis co-infec.pdf:pdf;:C$\backslash$:/Users/01462563/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Riou et al. - 2021 - Relationship of SARS-CoV-2-specific CD4 response to COVID-19 severity and impact of HIV-1 and tuberculosis co-in(2).pdf:pdf},
issn = {1558-8238},
journal = {Journal of Clinical Investigation},
keywords = {OA,OA{\_}PMC,fund{\_}ack,genomics{\_}fund{\_}ack,original},
mendeley-tags = {OA,OA{\_}PMC,fund{\_}ack,genomics{\_}fund{\_}ack,original},
month = {may},
number = {12},
pages = {e149125},
pmid = {33945513},
publisher = {American Society for Clinical Investigation},
title = {{Relationship of SARS-CoV-2-specific CD4 response to COVID-19 severity and impact of HIV-1 and tuberculosis co-infection}},
url = {http://www.jci.org/articles/view/149125},
volume = {131},
year = {2021}
}
Downloads: 1
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