@article{Riou2019a,
abstract = {The reconstitution of Mycobacterium tuberculosis antigen-specific CD4 T cells in a cohort of HIV-infected persons starting antiretroviral treatment (ART) in a high tuberculosis endemic area is described. Restoration of the antigen-specific CD4 T-cell subsets mirrored the overall CD4 T-cell compartment. Activation (assessed by HLA-DR expression) decreased during ART but remained elevated compared to HIV-uninfected persons. Despite known M. tuberculosis sensitization determined by interferon-$\gamma$ release assay, 12/23 participants had no M. tuberculosis-specific CD4 T cells detectable by flow cytometry, combined with overall elevated T-cell activation and memory differentiation, suggesting heightened turnover. Our data suggest early ART initiation to maintain polyfunctional immune memory responses.},
author = {Riou, Catherine and Jhilmeet, Nishtha and Rangaka, Molebogeng X and Wilkinson, Robert J and Wilkinson, Katalin A},
doi = {10.1093/infdis/jiz417},
file = {:C$\backslash$:/Users/01462563/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Riou et al. - 2020 - Tuberculosis antigen-specific T-cell responses during the first 6 months of antiretroviral treatment.pdf:pdf},
issn = {0022-1899},
journal = {The Journal of Infectious Diseases},
keywords = {OA,fund{\_}ack,original},
mendeley-tags = {OA,fund{\_}ack,original},
month = {aug},
number = {1},
pages = {162--167},
pmid = {31419285},
title = {{Tuberculosis antigen-specific T-cell responses during the first 6 months of antiretroviral treatment}},
url = {https://doi.org/10.1093/infdis/jiz417},
volume = {221},
year = {2020}
}

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