Synthesis of biodegradable liquid-core microcapsules composed of isocyanate functionalized poly(ε-caprolactone)-containing copolymers. Risangud, N., de Jongh, P. A. J. M., Wilson, P., & Haddleton, D. M. EUROPEAN POLYMER JOURNAL, October, 2021. doi abstract bibtex A combination of reversible deactivation radical polymerization (RDRP), isocyanate chemistry, and a convenient drying process via spray drying is employed to fabricate powder-form biodegradable liquid-core microcapsules. Two different molecular weight alpha,omega-poly(epsilon caprolactone) RDRP macroinitiators were first prepared through esterification to obtain the degradable a-halo ester initiators. Subsequently, poly(benzyl methacrylate-co-iso-cyanatoethyl methacrylate) (P(BnMA(a)-co-IEMb)) copolymers were synthesized from the RDRP macroinitiators using a copper(0)-mediated polymerization system at ambient temperature. By controlling the macroinitiator to monomer feeding ratio from 1:50 to 1:100, the resultant copolymers had number average molecular weights (M-n) in the range of 7900-17800 g mol(-1) with dispersities (D) of 1.42-1.52. Afterward, the isocyanate-containing copolymers were employed in the fabrication of particles via interfacial polymerization, followed by a water removal process using spray drying. All polymers and particles were thoroughly characterized using a range of spectroscopic, chromatographic and microscopy analyses.
@article{risangud_synthesis_2021,
title = {Synthesis of biodegradable liquid-core microcapsules composed of isocyanate functionalized poly(ε-caprolactone)-containing copolymers},
volume = {159},
issn = {0014-3057},
doi = {10.1016/j.eurpolymj.2021.110739},
abstract = {A combination of reversible deactivation radical polymerization (RDRP), isocyanate chemistry, and a convenient drying process via spray drying is employed to fabricate powder-form biodegradable liquid-core microcapsules. Two different molecular weight alpha,omega-poly(epsilon caprolactone) RDRP macroinitiators were first prepared through esterification to obtain the degradable a-halo ester initiators. Subsequently, poly(benzyl methacrylate-co-iso-cyanatoethyl methacrylate) (P(BnMA(a)-co-IEMb)) copolymers were synthesized from the RDRP macroinitiators using a copper(0)-mediated polymerization system at ambient temperature. By controlling the macroinitiator to monomer feeding ratio from 1:50 to 1:100, the resultant copolymers had number average molecular weights (M-n) in the range of 7900-17800 g mol(-1) with dispersities (D) of 1.42-1.52. Afterward, the isocyanate-containing copolymers were employed in the fabrication of particles via interfacial polymerization, followed by a water removal process using spray drying. All polymers and particles were thoroughly characterized using a range of spectroscopic, chromatographic and microscopy analyses.},
urldate = {2021-09-25},
journal = {EUROPEAN POLYMER JOURNAL},
author = {Risangud, Nuttapol and de Jongh, Patrick A. J. M. and Wilson, Paul and Haddleton, David M.},
month = oct,
year = {2021},
}
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