@article{ risbrough_role_2003,
  title = {Role of corticotropin releasing factor ({CRF}) receptors 1 and 2 in {CRF}-potentiated acoustic startle in mice},
  volume = {170},
  issn = {0033-3158},
  doi = {10.1007/s00213-003-1535-6},
  abstract = {{RATIONALE}: Hypersecretion of corticotropin releasing factor ({CRF}) has been implicated in both severe anxiety disorders and major depression. Although the role of the {CRF}1 receptor in the anxiogenic effects of {CRF} is well supported, the role of {CRF}2 receptors in anxiety-like behaviors is less clear. In rats, {CRF} increases the acoustic startle reflex ({ASR}) via its action in the extended amygdala, providing a putative measure of {CRF}-mediated anxiogenic activity.
{OBJECTIVE}: To characterize the effect of {CRF} on {ASR} in mice and determine the respective roles of {CRF}1 and {CRF}2 receptors in {CRF}-potentiated {ASR}.
{METHODS}: The present study examined: (1) the time course and dose response functions for the effects of human/rat (h/r)-{CRF} (0.02-0.6 nmol, {ICV} (intracerebroventricular)) on {ASR} in two inbred strains of mice; (2) the effects of the {CRF}1 receptor antagonist {NBI}-30775 (20 mg/kg, intraperitoneal) and the {CRF}2 receptor antagonist Antisauvagine-30 (1-10 nmol, {ICV}) on {CRF}-potentiated {ASR} and (3) the effects of the {CRF}2 receptor agonist urocortin 2 (0.2-6 nmol, {ICV}) on {ASR} in mice.
{RESULTS}: h/r-{CRF} significantly increased {ASR} in mice in a time-dependent manner with maximal efficacy at the 0.2 and 0.6 nmol doses. 129S6/{SvEvTac} mice exhibited a slightly increased duration of action and lower minimal effective dose threshold for {CRF} effects on {ASR} compared to C57BL/6J mice. Both selective {CRF}1)and {CRF}2)antagonists attenuated h/r-{CRF}-potentiated {ASR} without affecting acoustic startle when given alone. The selective {CRF}2 receptor agonist urocortin 2 increased {ASR} (1 and 2 nmol), albeit with less efficacy than the non-selective {CRF} receptor agonist h/r-{CRF}.
{CONCLUSIONS}: Both {CRF}1 and {CRF}2 receptors appear to contribute to the h/r-{CRF}-induced increases in {ASR} in mice. These data support the hypothesis that both receptors contribute to the anxiogenic effects of {CRF}.},
  language = {eng},
  number = {2},
  journal = {Psychopharmacology},
  author = {Risbrough, Victoria B and Hauger, Richard L and Pelleymounter, Mary Ann and Geyer, Mark A},
  month = {November},
  year = {2003},
  pmid = {12845406},
  keywords = {Animals, Area Under Curve, Behavior, Animal, Corticotropin-Releasing Hormone, Dose-Response Relationship, Drug, Dose-Response Relationship, Radiation, Drug Interactions, Male, Mice, Mice, Inbred Strains, Peptide Fragments, Pyrimidines, Receptors, Corticotropin-Releasing Hormone, Species Specificity, Startle Reaction, Time Factors, Urocortins},
  pages = {178--187}
}

{"_id":"wES9nStBYg7YmsjRr","authorIDs":[],"author_short":["Risbrough","B, V.","Hauger","L, R.","Pelleymounter","Ann, M.","Geyer","A, M."],"bibbaseid":"risbrough-b-hauger-l-pelleymounter-ann-geyer-a-roleofcorticotropinreleasingfactorcrfreceptors1and2incrfpotentiatedacousticstartleinmice-2003","bibdata":{"abstract":"RATIONALE: Hypersecretion of corticotropin releasing factor (CRF) has been implicated in both severe anxiety disorders and major depression. Although the role of the CRF1 receptor in the anxiogenic effects of CRF is well supported, the role of CRF2 receptors in anxiety-like behaviors is less clear. In rats, CRF increases the acoustic startle reflex (ASR) via its action in the extended amygdala, providing a putative measure of CRF-mediated anxiogenic activity. OBJECTIVE: To characterize the effect of CRF on ASR in mice and determine the respective roles of CRF1 and CRF2 receptors in CRF-potentiated ASR. METHODS: The present study examined: (1) the time course and dose response functions for the effects of human/rat (h/r)-CRF (0.02-0.6 nmol, ICV (intracerebroventricular)) on ASR in two inbred strains of mice; (2) the effects of the CRF1 receptor antagonist NBI-30775 (20 mg/kg, intraperitoneal) and the CRF2 receptor antagonist Antisauvagine-30 (1-10 nmol, ICV) on CRF-potentiated ASR and (3) the effects of the CRF2 receptor agonist urocortin 2 (0.2-6 nmol, ICV) on ASR in mice. RESULTS: h/r-CRF significantly increased ASR in mice in a time-dependent manner with maximal efficacy at the 0.2 and 0.6 nmol doses. 129S6/SvEvTac mice exhibited a slightly increased duration of action and lower minimal effective dose threshold for CRF effects on ASR compared to C57BL/6J mice. Both selective CRF1)and CRF2)antagonists attenuated h/r-CRF-potentiated ASR without affecting acoustic startle when given alone. The selective CRF2 receptor agonist urocortin 2 increased ASR (1 and 2 nmol), albeit with less efficacy than the non-selective CRF receptor agonist h/r-CRF. CONCLUSIONS: Both CRF1 and CRF2 receptors appear to contribute to the h/r-CRF-induced increases in ASR in mice. These data support the hypothesis that both receptors contribute to the anxiogenic effects of CRF.","author":["Risbrough","B, Victoria","Hauger","L, Richard","Pelleymounter","Ann, Mary","Geyer","A, Mark"],"author_short":["Risbrough","B, V.","Hauger","L, R.","Pelleymounter","Ann, M.","Geyer","A, M."],"bibtex":"@article{ risbrough_role_2003,\n title = {Role of corticotropin releasing factor ({CRF}) receptors 1 and 2 in {CRF}-potentiated acoustic startle in mice},\n volume = {170},\n issn = {0033-3158},\n doi = {10.1007/s00213-003-1535-6},\n abstract = {{RATIONALE}: Hypersecretion of corticotropin releasing factor ({CRF}) has been implicated in both severe anxiety disorders and major depression. Although the role of the {CRF}1 receptor in the anxiogenic effects of {CRF} is well supported, the role of {CRF}2 receptors in anxiety-like behaviors is less clear. In rats, {CRF} increases the acoustic startle reflex ({ASR}) via its action in the extended amygdala, providing a putative measure of {CRF}-mediated anxiogenic activity.\n{OBJECTIVE}: To characterize the effect of {CRF} on {ASR} in mice and determine the respective roles of {CRF}1 and {CRF}2 receptors in {CRF}-potentiated {ASR}.\n{METHODS}: The present study examined: (1) the time course and dose response functions for the effects of human/rat (h/r)-{CRF} (0.02-0.6 nmol, {ICV} (intracerebroventricular)) on {ASR} in two inbred strains of mice; (2) the effects of the {CRF}1 receptor antagonist {NBI}-30775 (20 mg/kg, intraperitoneal) and the {CRF}2 receptor antagonist Antisauvagine-30 (1-10 nmol, {ICV}) on {CRF}-potentiated {ASR} and (3) the effects of the {CRF}2 receptor agonist urocortin 2 (0.2-6 nmol, {ICV}) on {ASR} in mice.\n{RESULTS}: h/r-{CRF} significantly increased {ASR} in mice in a time-dependent manner with maximal efficacy at the 0.2 and 0.6 nmol doses. 129S6/{SvEvTac} mice exhibited a slightly increased duration of action and lower minimal effective dose threshold for {CRF} effects on {ASR} compared to C57BL/6J mice. Both selective {CRF}1)and {CRF}2)antagonists attenuated h/r-{CRF}-potentiated {ASR} without affecting acoustic startle when given alone. The selective {CRF}2 receptor agonist urocortin 2 increased {ASR} (1 and 2 nmol), albeit with less efficacy than the non-selective {CRF} receptor agonist h/r-{CRF}.\n{CONCLUSIONS}: Both {CRF}1 and {CRF}2 receptors appear to contribute to the h/r-{CRF}-induced increases in {ASR} in mice. These data support the hypothesis that both receptors contribute to the anxiogenic effects of {CRF}.},\n language = {eng},\n number = {2},\n journal = {Psychopharmacology},\n author = {Risbrough, Victoria B and Hauger, Richard L and Pelleymounter, Mary Ann and Geyer, Mark A},\n month = {November},\n year = {2003},\n pmid = {12845406},\n keywords = {Animals, Area Under Curve, Behavior, Animal, Corticotropin-Releasing Hormone, Dose-Response Relationship, Drug, Dose-Response Relationship, Radiation, Drug Interactions, Male, Mice, Mice, Inbred Strains, Peptide Fragments, Pyrimidines, Receptors, Corticotropin-Releasing Hormone, Species Specificity, Startle Reaction, Time Factors, Urocortins},\n pages = {178--187}\n}","bibtype":"article","doi":"10.1007/s00213-003-1535-6","id":"risbrough_role_2003","issn":"0033-3158","journal":"Psychopharmacology","key":"risbrough_role_2003","keywords":"Animals, Area Under Curve, Behavior, Animal, Corticotropin-Releasing Hormone, Dose-Response Relationship, Drug, Dose-Response Relationship, Radiation, Drug Interactions, Male, Mice, Mice, Inbred Strains, Peptide Fragments, Pyrimidines, Receptors, Corticotropin-Releasing Hormone, Species Specificity, Startle Reaction, Time Factors, Urocortins","language":"eng","month":"November","number":"2","pages":"178--187","pmid":"12845406","title":"Role of corticotropin releasing factor (CRF) receptors 1 and 2 in CRF-potentiated acoustic startle in mice","type":"article","volume":"170","year":"2003","bibbaseid":"risbrough-b-hauger-l-pelleymounter-ann-geyer-a-roleofcorticotropinreleasingfactorcrfreceptors1and2incrfpotentiatedacousticstartleinmice-2003","role":"author","urls":{},"keyword":["Animals","Area Under Curve","Behavior","Animal","Corticotropin-Releasing Hormone","Dose-Response Relationship","Drug","Dose-Response Relationship","Radiation","Drug Interactions","Male","Mice","Mice","Inbred Strains","Peptide Fragments","Pyrimidines","Receptors","Corticotropin-Releasing Hormone","Species Specificity","Startle Reaction","Time Factors","Urocortins"],"downloads":0,"html":""},"bibtype":"article","biburl":"http://bibbase.org/zotero/brizard","creationDate":"2015-02-11T09:04:28.700Z","downloads":0,"keywords":["animals","area under curve","behavior","animal","corticotropin-releasing hormone","dose-response relationship","drug","dose-response relationship","radiation","drug interactions","male","mice","mice","inbred strains","peptide fragments","pyrimidines","receptors","corticotropin-releasing hormone","species specificity","startle reaction","time factors","urocortins"],"search_terms":["role","corticotropin","releasing","factor","crf","receptors","crf","potentiated","acoustic","startle","mice","risbrough","b","hauger","l","pelleymounter","ann","geyer","a"],"title":"Role of corticotropin releasing factor (CRF) receptors 1 and 2 in CRF-potentiated acoustic startle in mice","year":2003,"dataSources":["H9yznXMN7R8ae2jTA"]}