Unintended effects in genetically modified crops: revealed by metabolomics?. Rischer, H. and Oksman-Caldentey, K. Trends in Biotechnology, 24(3):102, 2006.
abstract   bibtex   
In Europe the commercialization of food derived from genetically modified plants has been slow because of the complex regulatory process and the concerns of consumers. Risk assessment is focused on potential adverse effects on humans and the environment, which could result from unintended effects of genetic modifications: unintended effects are connected to changes in metabolite levels in the plants. One of the major challenges is how to analyze the overall metabolite composition of GM plants in comparison to conventional cultivars, and one possible solution is offered by metabolomics. The ultimate aim of metabolomics is the identification and quantification of all small molecules in an organism; however, a single method enabling complete metabolome analysis does not exist. Given a comprehensive extraction method, a hierarchical strategy – starting with global fingerprinting and followed by complementary profiling attempts – is the most logical and economic approach to detect unintended effects in GM crops.
@article{
 title = {Unintended effects in genetically modified crops: revealed by metabolomics?},
 type = {article},
 year = {2006},
 keywords = {metabolic engineering},
 pages = {102},
 volume = {24},
 websites = {http://www.sciencedirect.com/science/article/B6TCW-4J6WNXK-3/2/8e36447b852bdac4fba6be39caf8c810},
 id = {180ac5ee-4692-310a-a41c-4a438539f577},
 created = {2012-01-05T13:08:45.000Z},
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 profile_id = {1a467167-0a41-3583-a6a3-034c31031332},
 group_id = {0e532975-1a47-38a4-ace8-4fe5968bcd72},
 last_modified = {2012-01-05T13:14:57.000Z},
 tags = {GMO Pleiotropism},
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 starred = {false},
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 source_type = {Journal Article},
 abstract = {In Europe the commercialization of food derived from genetically modified plants has been slow because of the complex regulatory process and the concerns of consumers. Risk assessment is focused on potential adverse effects on humans and the environment, which could result from unintended effects of genetic modifications: unintended effects are connected to changes in metabolite levels in the plants. One of the major challenges is how to analyze the overall metabolite composition of GM plants in comparison to conventional cultivars, and one possible solution is offered by metabolomics. The ultimate aim of metabolomics is the identification and quantification of all small molecules in an organism; however, a single method enabling complete metabolome analysis does not exist. Given a comprehensive extraction method, a hierarchical strategy – starting with global fingerprinting and followed by complementary profiling attempts – is the most logical and economic approach to detect unintended effects in GM crops.},
 bibtype = {article},
 author = {Rischer, Heiko and Oksman-Caldentey, Kirsi-Marja},
 journal = {Trends in Biotechnology},
 number = {3}
}
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