A comprehensive investigation of amino grafted mesoporous silica nanoparticles supramolecular assemblies to host photoactive chlorophyll a in aqueous solution

A comprehensive investigation of amino grafted mesoporous silica nanoparticles supramolecular assemblies to host photoactive chlorophyll a in aqueous solution. Rizzi, V., Gubitosa, J., Fini, P., Fanelli, F., Fraix, A., Sortino, S., Agostiano, A., De Cola, L., Nacci, A., & Cosma, P. Journal of Photochemistry and Photobiology A: Chemistry, 377:149-158, Elsevier B.V., 2019. cited By 2

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Highly ordered Mesoporous Silica Nanoparticles (MSNs), belonging to MCM-41 family (100 nm wide), with a mean pore size of about 4 nm, are used as carrier for the hydrophobic photosensitizer (PS) Chlorophyll a (Chl) in water medium. In future perspective to study the proposed system in Photodynamic Therapy (PDT) and/or in antimicrobial-PDT (aPDT), advances in Chl studies in aqueous solution, mimicking the biological environment, were presented during this work with the main aim to obtain a supramolecular assembly able to host photoactive Chl in water medium. As synthetized MSNs and amino grafted MSNs (MSNs-NH 2 ) were studied and carefully characterized, with and without Chl, using TGA, SEM, TEM, SAXS, Nitrogen physisorption isotherms, Z-potential investigation, FTIR-ATR and UV–vis absorption/fluorescence analyses, including also the Chl fluorescence lifetime evaluation. To drive Chl inside the pores, the drug loading method by using the adsorption process, was adopted. The NH 2 moieties exerted a key role to host Chl inside the MSNs-NH 2 pores, allowing to obtain Chl as monomer. Electrostatic interactions through positively charged amino groups were evidenced, along with the hydrogen bond presence involving the pigment hydrated form and the MSNs-NH 2 . Two Chl populations, i.e. ascribed to the monomeric and dimeric one, were revealed by 1 Chl* lifetime measurements and steady state fluorescence emission. The presence of photoactive Chl molecules was demonstrated with the qualitative evaluation of 1 O 2 by means of chemical probes. © 2019 Elsevier B.V.

@ARTICLE{Rizzi2019149,
author={Rizzi, V. and Gubitosa, J. and Fini, P. and Fanelli, F. and Fraix, A. and Sortino, S. and Agostiano, A. and De Cola, L. and Nacci, A. and Cosma, P.},
title={A comprehensive investigation of amino grafted mesoporous silica nanoparticles supramolecular assemblies to host photoactive chlorophyll a in aqueous solution},
journal={Journal of Photochemistry and Photobiology A: Chemistry},
year={2019},
volume={377},
pages={149-158},
doi={10.1016/j.jphotochem.2019.03.041},
note={cited By 2},
url={https://www.scopus.com/inward/record.uri?eid=2-s2.0-85063735085&doi=10.1016%2fj.jphotochem.2019.03.041&partnerID=40&md5=d380c33e7411690f0258b42db5ab3244},
abstract={Highly ordered Mesoporous Silica Nanoparticles (MSNs), belonging to MCM-41 family (100 nm wide), with a mean pore size of about 4 nm, are used as carrier for the hydrophobic photosensitizer (PS) Chlorophyll a (Chl) in water medium. In future perspective to study the proposed system in Photodynamic Therapy (PDT) and/or in antimicrobial-PDT (aPDT), advances in Chl studies in aqueous solution, mimicking the biological environment, were presented during this work with the main aim to obtain a supramolecular assembly able to host photoactive Chl in water medium. As synthetized MSNs and amino grafted MSNs (MSNs-NH 2 ) were studied and carefully characterized, with and without Chl, using TGA, SEM, TEM, SAXS, Nitrogen physisorption isotherms, Z-potential investigation, FTIR-ATR and UV–vis absorption/fluorescence analyses, including also the Chl fluorescence lifetime evaluation. To drive Chl inside the pores, the drug loading method by using the adsorption process, was adopted. The NH 2 moieties exerted a key role to host Chl inside the MSNs-NH 2 pores, allowing to obtain Chl as monomer. Electrostatic interactions through positively charged amino groups were evidenced, along with the hydrogen bond presence involving the pigment hydrated form and the MSNs-NH 2 . Two Chl populations, i.e. ascribed to the monomeric and dimeric one, were revealed by 1 Chl* lifetime measurements and steady state fluorescence emission. The presence of photoactive Chl molecules was demonstrated with the qualitative evaluation of 1 O 2 by means of chemical probes. © 2019 Elsevier B.V.},
publisher={Elsevier B.V.},
issn={10106030},
coden={JPPCE},
document_type={Article},
source={Scopus},
}

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