The Sensitivity of Human Tumor Cells to Quinone Bioreductive Drugs: What Role for DT-diaphorase?. Robertson, N., Stratford, I., Houlbrook, S., Carmichael, J., & Adams, G. Biochem.~Pharamcol., 44:409--412, 1992. doi abstract bibtex 15 human tumour cell lines (lung, breast and colon) have been evaluated for their sensitivity to the quinone based anti-cancer drugs Mitomycin C, Porfiromycin, and E09 (3-hydroxymethyl-5-aziridinyl-l-methyl-2-(IH-indole-4,7-dione)prop-$\beta$-en-$\alpha$-ol). Sensitivity has been compared with the intra-cellular levels of DT-diaphorase, an enzyme thought to be important in the reductive activation of these quinones. No correlation exists between levels of DT-diaphorase and sensitivity to Mitomycin C or Porfiromycin. However, for E09 those cell lines showing highest levels of DT-diaphorase activity tend to be the most sensitive.
@article{Robertson:1992aa,
Abstract = {15 human tumour cell lines (lung, breast and colon) have been evaluated for their sensitivity to the quinone based anti-cancer drugs Mitomycin C, Porfiromycin, and E09 (3-hydroxymethyl-5-aziridinyl-l-methyl-2-(IH-indole-4,7-dione)prop-$\beta$-en-$\alpha$-ol). Sensitivity has been compared with the intra-cellular levels of DT-diaphorase, an enzyme thought to be important in the reductive activation of these quinones. No correlation exists between levels of DT-diaphorase and sensitivity to Mitomycin C or Porfiromycin. However, for E09 those cell lines showing highest levels of DT-diaphorase activity tend to be the most sensitive.
},
Author = {Robertson, N. and Stratford, I.J. and Houlbrook, S. and Carmichael, J. and Adams, G.E.},
Date-Added = {2007-12-11 17:01:03 -0500},
Date-Modified = {2007-12-11 17:01:03 -0500},
Doi = {10.1016/0006-2952(92)90429-M},
Journal = {Biochem.~Pharamcol.},
Keywords = {quinone; anticancer; phosphorylation},
Pages = {409--412},
Title = {The Sensitivity of Human Tumor Cells to Quinone Bioreductive Drugs: {W}hat Role for {DT}-diaphorase?},
Volume = {44},
Year = {1992},
Bdsk-Url-1 = {http://dx.doi.org/10.1016/0006-2952(92)90429-M}}
Downloads: 0
{"_id":"mGQGpiSASS5To85pc","bibbaseid":"robertson-stratford-houlbrook-carmichael-adams-thesensitivityofhumantumorcellstoquinonebioreductivedrugswhatrolefordtdiaphorase-1992","downloads":0,"creationDate":"2016-02-18T13:03:34.579Z","title":"The Sensitivity of Human Tumor Cells to Quinone Bioreductive Drugs: What Role for DT-diaphorase?","author_short":["Robertson, N.","Stratford, I.","Houlbrook, S.","Carmichael, J.","Adams, G."],"year":1992,"bibtype":"article","biburl":"https://dl.dropboxusercontent.com/u/26998770/main.bib","bibdata":{"bibtype":"article","type":"article","abstract":"15 human tumour cell lines (lung, breast and colon) have been evaluated for their sensitivity to the quinone based anti-cancer drugs Mitomycin C, Porfiromycin, and E09 (3-hydroxymethyl-5-aziridinyl-l-methyl-2-(IH-indole-4,7-dione)prop-$\\beta$-en-$\\alpha$-ol). Sensitivity has been compared with the intra-cellular levels of DT-diaphorase, an enzyme thought to be important in the reductive activation of these quinones. No correlation exists between levels of DT-diaphorase and sensitivity to Mitomycin C or Porfiromycin. However, for E09 those cell lines showing highest levels of DT-diaphorase activity tend to be the most sensitive. ","author":[{"propositions":[],"lastnames":["Robertson"],"firstnames":["N."],"suffixes":[]},{"propositions":[],"lastnames":["Stratford"],"firstnames":["I.J."],"suffixes":[]},{"propositions":[],"lastnames":["Houlbrook"],"firstnames":["S."],"suffixes":[]},{"propositions":[],"lastnames":["Carmichael"],"firstnames":["J."],"suffixes":[]},{"propositions":[],"lastnames":["Adams"],"firstnames":["G.E."],"suffixes":[]}],"date-added":"2007-12-11 17:01:03 -0500","date-modified":"2007-12-11 17:01:03 -0500","doi":"10.1016/0006-2952(92)90429-M","journal":"Biochem.~Pharamcol.","keywords":"quinone; anticancer; phosphorylation","pages":"409--412","title":"The Sensitivity of Human Tumor Cells to Quinone Bioreductive Drugs: What Role for DT-diaphorase?","volume":"44","year":"1992","bdsk-url-1":"http://dx.doi.org/10.1016/0006-2952(92)90429-M","bibtex":"@article{Robertson:1992aa,\n\tAbstract = {15 human tumour cell lines (lung, breast and colon) have been evaluated for their sensitivity to the quinone based anti-cancer drugs Mitomycin C, Porfiromycin, and E09 (3-hydroxymethyl-5-aziridinyl-l-methyl-2-(IH-indole-4,7-dione)prop-$\\beta$-en-$\\alpha$-ol). Sensitivity has been compared with the intra-cellular levels of DT-diaphorase, an enzyme thought to be important in the reductive activation of these quinones. No correlation exists between levels of DT-diaphorase and sensitivity to Mitomycin C or Porfiromycin. However, for E09 those cell lines showing highest levels of DT-diaphorase activity tend to be the most sensitive.\n},\n\tAuthor = {Robertson, N. and Stratford, I.J. and Houlbrook, S. and Carmichael, J. and Adams, G.E.},\n\tDate-Added = {2007-12-11 17:01:03 -0500},\n\tDate-Modified = {2007-12-11 17:01:03 -0500},\n\tDoi = {10.1016/0006-2952(92)90429-M},\n\tJournal = {Biochem.~Pharamcol.},\n\tKeywords = {quinone; anticancer; phosphorylation},\n\tPages = {409--412},\n\tTitle = {The Sensitivity of Human Tumor Cells to Quinone Bioreductive Drugs: {W}hat Role for {DT}-diaphorase?},\n\tVolume = {44},\n\tYear = {1992},\n\tBdsk-Url-1 = {http://dx.doi.org/10.1016/0006-2952(92)90429-M}}\n\n","author_short":["Robertson, N.","Stratford, I.","Houlbrook, S.","Carmichael, J.","Adams, G."],"key":"Robertson:1992aa","id":"Robertson:1992aa","bibbaseid":"robertson-stratford-houlbrook-carmichael-adams-thesensitivityofhumantumorcellstoquinonebioreductivedrugswhatrolefordtdiaphorase-1992","role":"author","urls":{},"keyword":["quinone; anticancer; phosphorylation"],"downloads":0},"search_terms":["sensitivity","human","tumor","cells","quinone","bioreductive","drugs","role","diaphorase","robertson","stratford","houlbrook","carmichael","adams"],"keywords":["quinone; anticancer; phosphorylation"],"authorIDs":[],"dataSources":["c5japf9eAQRaeMS4h"]}