The Sensitivity of Human Tumor Cells to Quinone Bioreductive Drugs: What Role for DT-diaphorase?. Robertson, N., Stratford, I., Houlbrook, S., Carmichael, J., & Adams, G. Biochem.~Pharamcol., 44:409--412, 1992.
doi  abstract   bibtex   
15 human tumour cell lines (lung, breast and colon) have been evaluated for their sensitivity to the quinone based anti-cancer drugs Mitomycin C, Porfiromycin, and E09 (3-hydroxymethyl-5-aziridinyl-l-methyl-2-(IH-indole-4,7-dione)prop-$\beta$-en-$\alpha$-ol). Sensitivity has been compared with the intra-cellular levels of DT-diaphorase, an enzyme thought to be important in the reductive activation of these quinones. No correlation exists between levels of DT-diaphorase and sensitivity to Mitomycin C or Porfiromycin. However, for E09 those cell lines showing highest levels of DT-diaphorase activity tend to be the most sensitive.
@article{Robertson:1992aa,
	Abstract = {15 human tumour cell lines (lung, breast and colon) have been evaluated for their sensitivity to the quinone based anti-cancer drugs Mitomycin C, Porfiromycin, and E09 (3-hydroxymethyl-5-aziridinyl-l-methyl-2-(IH-indole-4,7-dione)prop-$\beta$-en-$\alpha$-ol). Sensitivity has been compared with the intra-cellular levels of DT-diaphorase, an enzyme thought to be important in the reductive activation of these quinones. No correlation exists between levels of DT-diaphorase and sensitivity to Mitomycin C or Porfiromycin. However, for E09 those cell lines showing highest levels of DT-diaphorase activity tend to be the most sensitive.
},
	Author = {Robertson, N. and Stratford, I.J. and Houlbrook, S. and Carmichael, J. and Adams, G.E.},
	Date-Added = {2007-12-11 17:01:03 -0500},
	Date-Modified = {2007-12-11 17:01:03 -0500},
	Doi = {10.1016/0006-2952(92)90429-M},
	Journal = {Biochem.~Pharamcol.},
	Keywords = {quinone; anticancer; phosphorylation},
	Pages = {409--412},
	Title = {The Sensitivity of Human Tumor Cells to Quinone Bioreductive Drugs: {W}hat Role for {DT}-diaphorase?},
	Volume = {44},
	Year = {1992},
	Bdsk-Url-1 = {http://dx.doi.org/10.1016/0006-2952(92)90429-M}}

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