Stress increases aversive prediction error signal in the ventral striatum

Stress increases aversive prediction error signal in the ventral striatum. Robinson, O. J., Overstreet, C., Charney, D. R., Vytal, K., & Grillon, C. Proceedings of the National Academy of Sciences, 110(10):4129–4133, March, 2013.

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From job interviews to the heat of battle, it is evident that people think and learn differently when stressed. In fact, learning under stress may have long-term consequences; stress facilitates aversive conditioning and associations learned during extreme stress may result in debilitating emotional responses in posttraumatic stress disorder. The mechanisms underpinning such stress-related associations, however, are unknown. Computational neuroscience has successfully characterized several mechanisms critical for associative learning under normative conditions. One such mechanism, the detection of a mismatch between expected and observed outcomes within the ventral striatum (i.e., “prediction errors”), is thought to be a critical precursor to the formation of new stimulus–outcome associations. An untested possibility, therefore, is that stress may affect learning via modulation of this mechanism. Here we combine a translational model of stress with a cognitive neuroimaging paradigm to demonstrate that stress significantly increases ventral striatum aversive (but not appetitive) prediction error signal. This provides a unique account of the propensity to form threat-related associations under stress with direct implications for our understanding of both normal stress and stress-related disorders.

@article{robinson_stress_2013,
	title = {Stress increases aversive prediction error signal in the ventral striatum},
	volume = {110},
	copyright = {All rights reserved},
	issn = {0027-8424, 1091-6490},
	url = {https://pnas.org/doi/full/10.1073/pnas.1213923110},
	doi = {10.1073/pnas.1213923110},
	abstract = {From job interviews to the heat of battle, it is evident that people think and learn differently when stressed. In fact, learning under stress may have long-term consequences; stress facilitates aversive conditioning and associations learned during extreme stress may result in debilitating emotional responses in posttraumatic stress disorder. The mechanisms underpinning such stress-related associations, however, are unknown. Computational neuroscience has successfully characterized several mechanisms critical for associative learning under normative conditions. One such mechanism, the detection of a mismatch between expected and observed outcomes within the ventral striatum (i.e., “prediction errors”), is thought to be a critical precursor to the formation of new stimulus–outcome associations. An untested possibility, therefore, is that stress may affect learning via modulation of this mechanism. Here we combine a translational model of stress with a cognitive neuroimaging paradigm to demonstrate that stress significantly increases ventral striatum aversive (but not appetitive) prediction error signal. This provides a unique account of the propensity to form threat-related associations under stress with direct implications for our understanding of both normal stress and stress-related disorders.},
	language = {en},
	number = {10},
	urldate = {2023-04-06},
	journal = {Proceedings of the National Academy of Sciences},
	author = {Robinson, Oliver J. and Overstreet, Cassie and Charney, Danielle R. and Vytal, Katherine and Grillon, Christian},
	month = mar,
	year = {2013},
	pages = {4129--4133},
}

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