Cardiac ion channels. Roden, D., Balser, J., AL, J. G., & Anderson, M. Annu Rev Physiol, 64:431–475, 2002. bibtex @Article{RSM:Rod2002,
author = "D.M. Roden and J.R. Balser and J.r. George AL and M.E.
Anderson",
title = "Cardiac ion channels.",
journal = "Annu Rev Physiol",
year = "2002",
volume = "64",
pages = "431--475",
robnote = "The normal electrophysiologic behavior of the heart is
determined by ordered propagation of excitatory stimuli
that result in rapid depolarization and slow
repolarization, thereby generating action potentials in
individual myocytes. Abnormalities of impulse
generation, propagation, or the duration and
configuration of individual cardiac action potentials
form the basis of disorders of cardiac rhythm, a
continuing major public health problem for which
available drugs are incompletetly effective and often
dangerous. The integrated activity of specific ionic
currents generates action potentials, and the genes
whose expression results in the molecular components
underlying individual ion currents in heart have been
cloned. This review discusses these new tools and how
their application to the problem of arrhythmias is
generating new mechanistic insights to identify
patients at risk for this condition and developing
improved antiarrhythmic therapies.",
bibdate = "Mon Nov 20 07:50:06 2006",
}
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