The association between meniscal damage of the posterior horns and localized posterior synovitis detected on T1-weighted contrast-enhanced MRI--the MOST study. Roemer, F. W., Felson, D. T., Yang, T., Niu, J., Crema, M. D., Englund, M., Nevitt, M. C., Zhang, Y., Lynch, J. A., El Khoury, G. Y., Torner, J., Lewis, C. E., & Guermazi, A. 42(6):573--581.
doi  abstract   bibtex   
OBJECTIVE: Synovitis is thought to be a secondary phenomenon in the osteoarthritis (OA) process and the menisci might be triggers of localized synovitis. The aim was to assess the cross-sectional associations of posterior horn meniscal damage with perimeniscal synovitis, and with synovitis posterior to the posterior cruciate ligament (PCL) using contrast enhanced (CE) MRI. DESIGN: The Multicenter Osteoarthritis (MOST) Study is a longitudinal observational study of subjects with or at risk for knee OA. Subjects are a subset of MOST who were examined with 1.5T CE MRI and had semiquantitative synovitis (scored from 0 to 2 at 11 locations) and meniscal readings (scored with WORMS from 0 to 4) available. Logistic regression was used to assess the association of posterior meniscal damage and perimeniscal synovitis in the same compartment, and between posterior meniscal damage and synovitis posterior to the PCL. RESULTS: Three hundred and seventy seven knees were included (mean age 61.1 years+/-6.9, mean BMI 29.6+/-4.9, 44.3% women). The odds for ipsi-compartmental perimeniscal synovitis were increased for knees with medial posterior horn meniscal damage (adjusted odds ratio [aOR] 2.5, 95% confidence intervals [95% CI] 1.3,4.8), but not for lateral damage (aOR 1.7, 95% CI 0.4,6.6). No positive associations were found for meniscal damage and presence of synovitis posterior to the PCL (aOR 0.9, 95% CI 0.6,1.5). CONCLUSIONS: Meniscal damage of the posterior horns is associated with ipsi-compartmental perimensical synovitis. No associations were found for posterior horn meniscal damage with synovitis posterior to the PCL, which suggests that synovitis posterior to the PCL is likely to be triggered by different pathomechanisms.
@article{roemer_association_2013,
	title = {The association between meniscal damage of the posterior horns and localized posterior synovitis detected on T1-weighted contrast-enhanced {MRI}--the {MOST} study.},
	volume = {42},
	rights = {Copyright (c) 2013 Elsevier Inc. All rights reserved.},
	issn = {1532-866X 0049-0172},
	doi = {10.1016/j.semarthrit.2012.10.005},
	abstract = {{OBJECTIVE}: Synovitis is thought to be a secondary phenomenon in the osteoarthritis ({OA}) process and the menisci might be triggers of localized synovitis. The aim was to assess the cross-sectional associations of posterior horn meniscal damage with perimeniscal synovitis, and with synovitis posterior to the posterior cruciate ligament ({PCL}) using contrast enhanced ({CE}) {MRI}. {DESIGN}: The Multicenter Osteoarthritis ({MOST}) Study is a longitudinal observational study of subjects with or at risk for knee {OA}. Subjects are a subset of {MOST} who were examined with 1.5T {CE} {MRI} and had semiquantitative synovitis (scored from 0 to 2  at 11 locations) and meniscal readings (scored with {WORMS} from 0 to 4) available. Logistic regression was used to assess the association of posterior meniscal damage and perimeniscal synovitis in the same compartment, and between posterior  meniscal damage and synovitis posterior to the {PCL}. {RESULTS}: Three hundred and seventy seven knees were included (mean age 61.1 years+/-6.9, mean {BMI} 29.6+/-4.9, 44.3\% women). The odds for ipsi-compartmental perimeniscal synovitis  were increased for knees with medial posterior horn meniscal damage (adjusted odds ratio [{aOR}] 2.5, 95\% confidence intervals [95\% {CI}] 1.3,4.8), but not for lateral damage ({aOR} 1.7, 95\% {CI} 0.4,6.6). No positive associations were found for meniscal damage and presence of synovitis posterior to the {PCL} ({aOR} 0.9, 95\% {CI} 0.6,1.5). {CONCLUSIONS}: Meniscal damage of the posterior horns is associated with  ipsi-compartmental perimensical synovitis. No associations were found for posterior horn meniscal damage with synovitis posterior to the {PCL}, which suggests that synovitis posterior to the {PCL} is likely to be triggered by different pathomechanisms.},
	pages = {573--581},
	number = {6},
	journaltitle = {Seminars in arthritis and rheumatism},
	shortjournal = {Semin Arthritis Rheum},
	author = {Roemer, Frank W. and Felson, David T. and Yang, Tianzhong and Niu, Jingbo and Crema, Michel D. and Englund, Martin and Nevitt, Michael C. and Zhang, Yuqing and Lynch, John A. and El Khoury, George Y. and Torner, James and Lewis, Cora E. and Guermazi, Ali},
	date = {2013-06},
	pmid = {23270763},
	pmcid = {PMC3640766},
	keywords = {Aged, Female, Humans, Knee Joint/*pathology, Magnetic Resonance Imaging/*methods, Male, Menisci, Tibial/*pathology, Middle Aged, Osteoarthritis, Knee/complications/*pathology, Posterior Cruciate Ligament/pathology, Synovitis/complications/*pathology}
}
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