Development of MRI-defined structural tissue damage after anterior cruciate ligament injury over 5 years: The KANON study. Roemer, F. W., Lohmander, L. S., Englund, M., Guermazi, A., Åkesson, A., & Frobell, R. Radiology, 299(2):383–393, May, 2021. Number: 2 Publisher: Radiological Society of North America![Development of MRI-defined structural tissue damage after anterior cruciate ligament injury over 5 years: The KANON study [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex BackgroundMRI is used to evaluate structural joint changes after anterior cruciate ligament (ACL) injury, but no long-term data are available for comparing different treatment approaches.PurposeTo describe structural joint damage with MRI over a 5-year period in the Knee Anterior Cruciate Ligament, Nonsurgical versus Surgical Treatment (KANON) study and to compare frequencies of such tissue damage for a nonsurgical versus a surgical treatment strategy.Materials and MethodsIn this secondary analysis of a prospective trial (ISRCTN 84752559), 119 participants with an acute ACL injury were evaluated. Participants were enrolled from 2002 through 2006, the 2-year follow-up started in 2008, and the 5-year follow-up started in 2011. A 1.5-T MRI examination was performed at baseline and at 2- and 5-year follow-up. MRI scans were read according to a validated scoring instrument. Kruskal-Wallis tests were used to assess whether the frequencies of structural damage differed between the three as-treated groups.ResultsOf 119 participants (mean age, 26 years ± 5 [standard deviation]), 91 men were evaluated. At 2- and 5-year follow-up, respectively, 13% (15 of 117) and 13% (15 of 115) of knees showed incident cartilage damage in the medial tibiofemoral joint, 11% (13 of 117) and 17% (20 of 115) of knees showed incident cartilage damage in the lateral tibiofemoral joint, and 4% (five of 117) and 8% (nine of 115) of knees showed incident cartilage damage in the patellofemoral joint. Osteophyte development was seen in 23% (27 of 117) and 29% (33 of 115) of knees in the medial tibiofemoral joint, in 36% (42 of 117) and 43% (49 of 115) of knees in the lateral tibiofemoral joint, and in 35% (41 of 117) and 37% (42 of 115) of knees in the patellofemoral joint. No major differences between the groups were found for incident or worsening cartilage damage, bone marrow lesions, and osteophytes at 2 or 5 years. The rehabilitation-alone group showed less Hoffa-synovitis at 2 (P = .02) and 5 (P = .008) years.ConclusionYoung adults with anterior cruciate ligament injury showed no major difference in frequency of structural tissue damage on MRI scans at 2 and 5 years regardless of treatment. However, the rehabilitation-alone group had less inflammation at 2 and 5 years.© RSNA, 2021Online supplemental material is available for this article.See also the editorial by Andreisek in this issue.
@article{roemer_development_2021,
title = {Development of {MRI}-defined structural tissue damage after anterior cruciate ligament injury over 5 years: {The} {KANON} study},
volume = {299},
issn = {0033-8419},
shorttitle = {Development of {MRI}-defined {Structural} {Tissue} {Damage} after {Anterior} {Cruciate} {Ligament} {Injury} over 5 {Years}},
url = {https://pubs.rsna.org/doi/10.1148/radiol.2021202954},
doi = {10.1148/radiol.2021202954},
abstract = {BackgroundMRI is used to evaluate structural joint changes after anterior cruciate ligament (ACL) injury, but no long-term data are available for comparing different treatment approaches.PurposeTo describe structural joint damage with MRI over a 5-year period in the Knee Anterior Cruciate Ligament, Nonsurgical versus Surgical Treatment (KANON) study and to compare frequencies of such tissue damage for a nonsurgical versus a surgical treatment strategy.Materials and MethodsIn this secondary analysis of a prospective trial (ISRCTN 84752559), 119 participants with an acute ACL injury were evaluated. Participants were enrolled from 2002 through 2006, the 2-year follow-up started in 2008, and the 5-year follow-up started in 2011. A 1.5-T MRI examination was performed at baseline and at 2- and 5-year follow-up. MRI scans were read according to a validated scoring instrument. Kruskal-Wallis tests were used to assess whether the frequencies of structural damage differed between the three as-treated groups.ResultsOf 119 participants (mean age, 26 years ± 5 [standard deviation]), 91 men were evaluated. At 2- and 5-year follow-up, respectively, 13\% (15 of 117) and 13\% (15 of 115) of knees showed incident cartilage damage in the medial tibiofemoral joint, 11\% (13 of 117) and 17\% (20 of 115) of knees showed incident cartilage damage in the lateral tibiofemoral joint, and 4\% (five of 117) and 8\% (nine of 115) of knees showed incident cartilage damage in the patellofemoral joint. Osteophyte development was seen in 23\% (27 of 117) and 29\% (33 of 115) of knees in the medial tibiofemoral joint, in 36\% (42 of 117) and 43\% (49 of 115) of knees in the lateral tibiofemoral joint, and in 35\% (41 of 117) and 37\% (42 of 115) of knees in the patellofemoral joint. No major differences between the groups were found for incident or worsening cartilage damage, bone marrow lesions, and osteophytes at 2 or 5 years. The rehabilitation-alone group showed less Hoffa-synovitis at 2 (P = .02) and 5 (P = .008) years.ConclusionYoung adults with anterior cruciate ligament injury showed no major difference in frequency of structural tissue damage on MRI scans at 2 and 5 years regardless of treatment. However, the rehabilitation-alone group had less inflammation at 2 and 5 years.© RSNA, 2021Online supplemental material is available for this article.See also the editorial by Andreisek in this issue.},
number = {2},
urldate = {2021-03-29},
journal = {Radiology},
author = {Roemer, Frank W. and Lohmander, L. Stefan and Englund, Martin and Guermazi, Ali and Åkesson, Anna and Frobell, Richard},
month = may,
year = {2021},
note = {Number: 2
Publisher: Radiological Society of North America},
pages = {383--393},
}
Downloads: 0
{"_id":"hTbxLa9HLxnGsJgtQ","bibbaseid":"roemer-lohmander-englund-guermazi-kesson-frobell-developmentofmridefinedstructuraltissuedamageafteranteriorcruciateligamentinjuryover5yearsthekanonstudy-2021","author_short":["Roemer, F. W.","Lohmander, L. S.","Englund, M.","Guermazi, A.","Åkesson, A.","Frobell, R."],"bibdata":{"bibtype":"article","type":"article","title":"Development of MRI-defined structural tissue damage after anterior cruciate ligament injury over 5 years: The KANON study","volume":"299","issn":"0033-8419","shorttitle":"Development of MRI-defined Structural Tissue Damage after Anterior Cruciate Ligament Injury over 5 Years","url":"https://pubs.rsna.org/doi/10.1148/radiol.2021202954","doi":"10.1148/radiol.2021202954","abstract":"BackgroundMRI is used to evaluate structural joint changes after anterior cruciate ligament (ACL) injury, but no long-term data are available for comparing different treatment approaches.PurposeTo describe structural joint damage with MRI over a 5-year period in the Knee Anterior Cruciate Ligament, Nonsurgical versus Surgical Treatment (KANON) study and to compare frequencies of such tissue damage for a nonsurgical versus a surgical treatment strategy.Materials and MethodsIn this secondary analysis of a prospective trial (ISRCTN 84752559), 119 participants with an acute ACL injury were evaluated. Participants were enrolled from 2002 through 2006, the 2-year follow-up started in 2008, and the 5-year follow-up started in 2011. A 1.5-T MRI examination was performed at baseline and at 2- and 5-year follow-up. MRI scans were read according to a validated scoring instrument. Kruskal-Wallis tests were used to assess whether the frequencies of structural damage differed between the three as-treated groups.ResultsOf 119 participants (mean age, 26 years ± 5 [standard deviation]), 91 men were evaluated. At 2- and 5-year follow-up, respectively, 13% (15 of 117) and 13% (15 of 115) of knees showed incident cartilage damage in the medial tibiofemoral joint, 11% (13 of 117) and 17% (20 of 115) of knees showed incident cartilage damage in the lateral tibiofemoral joint, and 4% (five of 117) and 8% (nine of 115) of knees showed incident cartilage damage in the patellofemoral joint. Osteophyte development was seen in 23% (27 of 117) and 29% (33 of 115) of knees in the medial tibiofemoral joint, in 36% (42 of 117) and 43% (49 of 115) of knees in the lateral tibiofemoral joint, and in 35% (41 of 117) and 37% (42 of 115) of knees in the patellofemoral joint. No major differences between the groups were found for incident or worsening cartilage damage, bone marrow lesions, and osteophytes at 2 or 5 years. The rehabilitation-alone group showed less Hoffa-synovitis at 2 (P = .02) and 5 (P = .008) years.ConclusionYoung adults with anterior cruciate ligament injury showed no major difference in frequency of structural tissue damage on MRI scans at 2 and 5 years regardless of treatment. However, the rehabilitation-alone group had less inflammation at 2 and 5 years.© RSNA, 2021Online supplemental material is available for this article.See also the editorial by Andreisek in this issue.","number":"2","urldate":"2021-03-29","journal":"Radiology","author":[{"propositions":[],"lastnames":["Roemer"],"firstnames":["Frank","W."],"suffixes":[]},{"propositions":[],"lastnames":["Lohmander"],"firstnames":["L.","Stefan"],"suffixes":[]},{"propositions":[],"lastnames":["Englund"],"firstnames":["Martin"],"suffixes":[]},{"propositions":[],"lastnames":["Guermazi"],"firstnames":["Ali"],"suffixes":[]},{"propositions":[],"lastnames":["Åkesson"],"firstnames":["Anna"],"suffixes":[]},{"propositions":[],"lastnames":["Frobell"],"firstnames":["Richard"],"suffixes":[]}],"month":"May","year":"2021","note":"Number: 2 Publisher: Radiological Society of North America","pages":"383–393","bibtex":"@article{roemer_development_2021,\n\ttitle = {Development of {MRI}-defined structural tissue damage after anterior cruciate ligament injury over 5 years: {The} {KANON} study},\n\tvolume = {299},\n\tissn = {0033-8419},\n\tshorttitle = {Development of {MRI}-defined {Structural} {Tissue} {Damage} after {Anterior} {Cruciate} {Ligament} {Injury} over 5 {Years}},\n\turl = {https://pubs.rsna.org/doi/10.1148/radiol.2021202954},\n\tdoi = {10.1148/radiol.2021202954},\n\tabstract = {BackgroundMRI is used to evaluate structural joint changes after anterior cruciate ligament (ACL) injury, but no long-term data are available for comparing different treatment approaches.PurposeTo describe structural joint damage with MRI over a 5-year period in the Knee Anterior Cruciate Ligament, Nonsurgical versus Surgical Treatment (KANON) study and to compare frequencies of such tissue damage for a nonsurgical versus a surgical treatment strategy.Materials and MethodsIn this secondary analysis of a prospective trial (ISRCTN 84752559), 119 participants with an acute ACL injury were evaluated. Participants were enrolled from 2002 through 2006, the 2-year follow-up started in 2008, and the 5-year follow-up started in 2011. A 1.5-T MRI examination was performed at baseline and at 2- and 5-year follow-up. MRI scans were read according to a validated scoring instrument. Kruskal-Wallis tests were used to assess whether the frequencies of structural damage differed between the three as-treated groups.ResultsOf 119 participants (mean age, 26 years ± 5 [standard deviation]), 91 men were evaluated. At 2- and 5-year follow-up, respectively, 13\\% (15 of 117) and 13\\% (15 of 115) of knees showed incident cartilage damage in the medial tibiofemoral joint, 11\\% (13 of 117) and 17\\% (20 of 115) of knees showed incident cartilage damage in the lateral tibiofemoral joint, and 4\\% (five of 117) and 8\\% (nine of 115) of knees showed incident cartilage damage in the patellofemoral joint. Osteophyte development was seen in 23\\% (27 of 117) and 29\\% (33 of 115) of knees in the medial tibiofemoral joint, in 36\\% (42 of 117) and 43\\% (49 of 115) of knees in the lateral tibiofemoral joint, and in 35\\% (41 of 117) and 37\\% (42 of 115) of knees in the patellofemoral joint. No major differences between the groups were found for incident or worsening cartilage damage, bone marrow lesions, and osteophytes at 2 or 5 years. The rehabilitation-alone group showed less Hoffa-synovitis at 2 (P = .02) and 5 (P = .008) years.ConclusionYoung adults with anterior cruciate ligament injury showed no major difference in frequency of structural tissue damage on MRI scans at 2 and 5 years regardless of treatment. However, the rehabilitation-alone group had less inflammation at 2 and 5 years.© RSNA, 2021Online supplemental material is available for this article.See also the editorial by Andreisek in this issue.},\n\tnumber = {2},\n\turldate = {2021-03-29},\n\tjournal = {Radiology},\n\tauthor = {Roemer, Frank W. and Lohmander, L. Stefan and Englund, Martin and Guermazi, Ali and Åkesson, Anna and Frobell, Richard},\n\tmonth = may,\n\tyear = {2021},\n\tnote = {Number: 2\nPublisher: Radiological Society of North America},\n\tpages = {383--393},\n}\n\n","author_short":["Roemer, F. W.","Lohmander, L. S.","Englund, M.","Guermazi, A.","Åkesson, A.","Frobell, R."],"key":"roemer_development_2021","id":"roemer_development_2021","bibbaseid":"roemer-lohmander-englund-guermazi-kesson-frobell-developmentofmridefinedstructuraltissuedamageafteranteriorcruciateligamentinjuryover5yearsthekanonstudy-2021","role":"author","urls":{"Paper":"https://pubs.rsna.org/doi/10.1148/radiol.2021202954"},"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://api.zotero.org/groups/5155143/items?key=IVTAjWy1U5EkGJqE2Z2qQCfh&format=bibtex&limit=100","dataSources":["7PYyrRz6AvkoBBchz","NGDbv8dMYDaDn8kqm","5jEuhQhgRx3py8LmG","LPTeGao77ndnG4Tks"],"keywords":[],"search_terms":["development","mri","defined","structural","tissue","damage","anterior","cruciate","ligament","injury","over","years","kanon","study","roemer","lohmander","englund","guermazi","åkesson","frobell"],"title":"Development of MRI-defined structural tissue damage after anterior cruciate ligament injury over 5 years: The KANON study","year":2021}