Functional proteogenomics reveals biomarkers and therapeutic targets in lymphomas. Rolland, D. C. M., Basrur, V., Jeon, Y., McNeil-Schwalm, C., Fermin, D., Conlon, K. P., Zhou, Y., Ng, S. Y., Tsou, C., Brown, N. A., Thomas, D. G., Bailey, N. G., Omenn, G. S., Nesvizhskii, A. I., Root, D. E., Weinstock, D. M., Faryabi, R. B., Lim, M. S., & Elenitoba-Johnson, K. S. J. Proceedings of the National Academy of Sciences of the United States of America, 114(25):6581–6586, June, 2017. doi abstract bibtex Identification of biomarkers and therapeutic targets is a critical goal of precision medicine. N-glycoproteins are a particularly attractive class of proteins that constitute potential cancer biomarkers and therapeutic targets for small molecules, antibodies, and cellular therapies. Using mass spectrometry (MS), we generated a compendium of 1,091 N-glycoproteins (from 40 human primary lymphomas and cell lines). Hierarchical clustering revealed distinct subtype signatures that included several subtype-specific biomarkers. Orthogonal immunological studies in 671 primary lymphoma tissue biopsies and 32 lymphoma-derived cell lines corroborated MS data. In anaplastic lymphoma kinase-positive (ALK(+)) anaplastic large cell lymphoma (ALCL), integration of
@article{rolland_functional_2017,
title = {Functional proteogenomics reveals biomarkers and therapeutic targets in lymphomas.},
volume = {114},
issn = {1091-6490 0027-8424},
doi = {10.1073/pnas.1701263114},
abstract = {Identification of biomarkers and therapeutic targets is a critical goal of precision medicine. N-glycoproteins are a particularly attractive class of proteins that constitute potential cancer biomarkers and therapeutic targets for small molecules, antibodies, and cellular therapies. Using mass spectrometry (MS), we generated a compendium of 1,091 N-glycoproteins (from 40 human primary lymphomas and cell lines). Hierarchical clustering revealed distinct subtype signatures that included several subtype-specific biomarkers. Orthogonal immunological studies in 671 primary lymphoma tissue biopsies and 32 lymphoma-derived cell lines corroborated MS data. In anaplastic lymphoma kinase-positive (ALK(+)) anaplastic large cell lymphoma (ALCL), integration of},
language = {eng},
number = {25},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
author = {Rolland, Delphine C. M. and Basrur, Venkatesha and Jeon, Yoon-Kyung and McNeil-Schwalm, Carla and Fermin, Damian and Conlon, Kevin P. and Zhou, Yeqiao and Ng, Samuel Y. and Tsou, Chih-Chiang and Brown, Noah A. and Thomas, Dafydd G. and Bailey, Nathanael G. and Omenn, Gilbert S. and Nesvizhskii, Alexey I. and Root, David E. and Weinstock, David M. and Faryabi, Robert B. and Lim, Megan S. and Elenitoba-Johnson, Kojo S. J.},
month = jun,
year = {2017},
pmid = {28607076},
pmcid = {PMC5488937},
keywords = {*CRISPR screen, *RNA-seq, *biomarkers, *lymphoma, *proteomics, Biomarkers, Tumor/*genetics, Cell Line, Tumor, Humans, Lymphoma/*genetics, Proteogenomics/methods, Receptor Protein-Tyrosine Kinases/genetics, Signal Transduction/genetics, Transcriptome/*genetics},
pages = {6581--6586}
}
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