@article{Rossenkhan2025,
abstract = {In HIV prevention trials, accurate timing estimates of when individual participants acquire HIV can be used to estimate antibody levels at the time of acquisition, which is useful for projecting antibody levels needed for prevention. The results we report here suggest that if sequence-based estimation of acquisition timing is used in future clinical trials of combination broadly neutralizing antibody (bnAb) regimens or multispecific bnAbs for HIV prevention, a sampling frequency of at least monthly is needed. Moreover, in the samples analyzed here, we observed less bias in sequence-based timing estimation for samples taken {\textless}5 weeks post-DDA. This observation is consistent with the timing of immune-driven selective pressures that may negatively impact the power to detect acquisition sieve effects.},
author = {Rossenkhan, Raabya and Giorgi, Elena E and Shao, Danica and Ludwig, James and Labuschagne, Phillip and Magaret, Craig A and Ndung'u, Thumbi and Muema, Daniel and Gounder, Kamini and Dong, Krista L and Walker, Bruce D and Rolland, Morgane and Robb, Merlin L and Eller, Leigh Anne and Sawe, Fredrick and Nitayaphan, Sorachai and Grebe, Eduard and Busch, Michael P and Delaney, Kevin P and Facente, Shelley and Carpp, Lindsay N and DeCamp, Allan C and Huang, Yunda and Korber, Bette and Juraska, Michal and Rudnicki, Erika and Kosmider, Ewelina and Reeves, Daniel B and Mayer, Bryan T and Hural, John and Deng, Wenjie and Westfall, Dylan H and Yssel, Anna and Matten, David and Bhattacharya, Tanmoy and Corey, Lawrence and Gilbert, Peter B and Williamson, Carolyn and Mullins, James I and Edlefsen, Paul T},
doi = {10.1128/MBIO.01881-25},
editor = {Mahalingam, Suresh},
file = {:C$\backslash$:/Users/01462563/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Rossenkhan et al. - 2025 - Bayesian estimation of HIV acquisition dates for prevention trials.pdf:pdf},
issn = {2150-7511},
journal = {mBio},
keywords = {Antibody-Mediated Prevention (AMP) Studies,Bayesian posterior distribution,FRESH,HIV,OA,OA{\_}PMC,RV217,acute acquisition cohort,date of detectable acquisition,fund{\_}not{\_}ack,original},
mendeley-tags = {OA,OA{\_}PMC,fund{\_}not{\_}ack,original},
month = {sep},
pages = {10.1128/mbio.01881--25 1},
pmid = {40923785},
title = {{Bayesian estimation of HIV acquisition dates for prevention trials}},
url = {/doi/pdf/10.1128/mbio.01881-25?download=true},
year = {2025}
}

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