@article{RN185,
   author = {Rossmeisl, J. H., Jr. and Garcia, P. A. and Pancotto, T. E. and Robertson, J. L. and Henao-Guerrero, N. and Neal, R. E., 2nd and Ellis, T. L. and Davalos, R. V.},
   title = {Safety and feasibility of the NanoKnife system for irreversible electroporation ablative treatment of canine spontaneous intracranial gliomas},
   journal = {J Neurosurg},
   volume = {123},
   number = {4},
   pages = {1008-25},
   note = {1933-0693
Rossmeisl, John H Jr
Garcia, Paulo A
Pancotto, Theresa E
Robertson, John L
Henao-Guerrero, Natalia
Neal, Robert E 2nd
Ellis, Thomas L
Davalos, Rafael V
Clinical Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
United States
2015/07/04
J Neurosurg. 2015 Oct;123(4):1008-25. doi: 10.3171/2014.12.JNS141768. Epub 2015 Jul 3.},
   abstract = {OBJECT: Irreversible electroporation (IRE) is a novel nonthermal ablation technique that has been used for the treatment of solid cancers. However, it has not been evaluated for use in brain tumors. Here, the authors report on the safety and feasibility of using the NanoKnife IRE system for the treatment of spontaneous intracranial gliomas in dogs. METHODS: Client-owned dogs with a telencephalic glioma shown on MRI were eligible. Dog-specific treatment plans were generated by using MRI-based tissue segmentation, volumetric meshing, and finite element modeling. After biopsy confirmation of glioma, IRE treatment was delivered stereotactically with the NanoKnife system using pulse parameters and electrode configurations derived from therapeutic plans. The primary end point was an evaluation of safety over the 14 days immediately after treatment. Follow-up was continued for 12 months or until death with serial physical, neurological, laboratory, and MRI examinations. RESULTS: Seven dogs with glioma were treated. The mean age of the dogs was 9.3 ± 1.6 years, and the mean pretreatment tumor volume was 1.9 ± 1.4 cm(3). The median preoperative Karnofsky Performance Scale score was 70 (range 30-75). Severe posttreatment toxicity was observed in 2 of the 7 dogs; one developed fatal (Grade 5) aspiration pneumonia, and the other developed treatment-associated cerebral edema, which resulted in transient neurological deterioration. Results of posttreatment diagnostic imaging, tumor biopsies, and neurological examinations indicated that tumor ablation was achieved without significant direct neurotoxicity in 6 of the 7 dogs. The median 14-day post-IRE Karnofsky Performance Scale score of the 6 dogs that survived to discharge was 80 (range 60-90), and this score was improved over the pretreatment value in every case. Objective tumor responses were seen in 4 (80%) of 5 dogs with quantifiable target lesions. The median survival was 119 days (range 1 to > 940 days). CONCLUSION: With the incorporation of additional therapeutic planning procedures, the NanoKnife system is a novel technology capable of controlled IRE ablation of telencephalic gliomas.},
   keywords = {Animals
Brain Neoplasms/drug therapy/surgery/*veterinary
Combined Modality Therapy
Dog Diseases/*drug therapy/*surgery
Dogs
Electrochemotherapy/adverse effects/*methods
Feasibility Studies
Female
Glioma/drug therapy/surgery/*veterinary
Male
*Neurosurgical Procedures/instrumentation
Prospective Studies
*Telencephalon
CTCAE = Common Terminology Criteria for Adverse Events
DICOM = Digital Imaging and Communications in Medicine
GBM = glioblastoma multiforme
IRE = irreversible electroporation
IV = intravenous
KPS = Karnofsky Performance Scale
PBS = phosphate-buffered saline
PD = progressive disease
PDMS = polydimethylsiloxane
PGP = probe guide pedestal
RANO = response assessment in neurooncology
SD = stable disease
brain tumor
dog
electroporation
glioma
neurosurgery
oncology},
   ISSN = {0022-3085},
   DOI = {10.3171/2014.12.Jns141768},
   year = {2015},
   type = {Journal Article}
}