Tolerance of subcutaneously administered antibiotics: a French national prospective study. Roubaud-Baudron, C., Forestier, E., Fraisse, T., Gaillat, J., de Wazières, B., Pagani, L., Ingrand, I., Bernard, L., Gavazzi, G., & Paccalin, M. Age and Ageing, 46(1):151–155, January, 2017. doi abstract bibtex BACKGROUND/ OBJECTIVE: Although poorly documented, subcutaneous (SC) administration of antibiotics is common practice in France especially in Geriatrics Departments. The aim of this study was to determine the tolerance of such a practice. DESIGN: Prospective observational multicentre study. METHODS: Sixty-six physicians accepted to participate from 50 French Infectious Diseases and Geriatrics Departments. From May to September 2014, patients treated at least one day with SC antibiotics could be included. Modalities of subcutaneous administration, occurrence of local and systemic adverse effects (AE) and clinical course were collected until the end of the treatment. RESULTS: Two hundred-nineteen patients (83.0 [19–104] yo) were included. Ceftriaxone (n = 163, 74.4%), and ertapenem (n = 30, 13.7%) were the most often prescribed antibiotics. The SC route was mainly used because of poor venous access (65.3%) and/or palliative care (32.4%). Fifty patients (22.8%) experienced at least one local AE that led to an increased hospital stay for two patients (4.0%) and a discontinuation of the SC infusion in six patients (12.0%). A binary logistic regression for multivariate analysis identified the class of antibiotic (p = 0.002) especially teicoplanin and the use of rigid catheter (p = 0.009) as factors independently associated with AE. In over 80% of cases, SC antibiotics were well tolerated and associated with clinical recovery. CONCLUSIONS: SC administration of antibiotics leads to frequent but local and mild AE. Use of non-rigid catheter appears to be protective against AE. As it appears to be a safe alternative to the intravenous route, more studies are needed regarding efficacy and pharmacokinetics.
@article{roubaud-baudron_tolerance_2017,
title = {Tolerance of subcutaneously administered antibiotics: a {French} national prospective study},
volume = {46},
issn = {1468-2834},
shorttitle = {Tolerance of subcutaneously administered antibiotics},
doi = {10.1093/ageing/afw143},
abstract = {BACKGROUND/ OBJECTIVE: Although poorly documented, subcutaneous (SC) administration of antibiotics is common practice in France especially in Geriatrics Departments. The aim of this study was to determine the tolerance of such a practice.
DESIGN: Prospective observational multicentre study.
METHODS: Sixty-six physicians accepted to participate from 50 French Infectious Diseases and Geriatrics Departments. From May to September 2014, patients treated at least one day with SC antibiotics could be included. Modalities of subcutaneous administration, occurrence of local and systemic adverse effects (AE) and clinical course were collected until the end of the treatment.
RESULTS: Two hundred-nineteen patients (83.0 [19–104] yo) were included. Ceftriaxone (n = 163, 74.4\%), and ertapenem (n = 30, 13.7\%) were the most often prescribed antibiotics. The SC route was mainly used because of poor venous access (65.3\%) and/or palliative care (32.4\%). Fifty patients (22.8\%) experienced at least one local AE that led to an increased hospital stay for two patients (4.0\%) and a discontinuation of the SC infusion in six patients (12.0\%). A binary logistic regression for multivariate analysis identified the class of antibiotic (p = 0.002) especially teicoplanin and the use of rigid catheter (p = 0.009) as factors independently associated with AE. In over 80\% of cases, SC antibiotics were well tolerated and associated with clinical recovery.
CONCLUSIONS: SC administration of antibiotics leads to frequent but local and mild AE. Use of non-rigid catheter appears to be protective against AE. As it appears to be a safe alternative to the intravenous route, more studies are needed regarding efficacy and pharmacokinetics.},
language = {eng},
number = {1},
journal = {Age and Ageing},
author = {Roubaud-Baudron, Claire and Forestier, Emmanuel and Fraisse, Thibaut and Gaillat, Jacques and de Wazières, Benoit and Pagani, Leonardo and Ingrand, Isabelle and Bernard, Louis and Gavazzi, Gaëtan and Paccalin, Marc},
month = jan,
year = {2017},
pmid = {28181635},
keywords = {Adult, Aged, Aged, 80 and over, Anti-Bacterial Agents, Bacterial Infections, Catheters, Drug Administration Schedule, Drug-Related Side Effects and Adverse Reactions, Equipment Design, Female, France, Humans, Infusions, Subcutaneous, Logistic Models, Male, Middle Aged, Multivariate Analysis, Odds Ratio, Prospective Studies, Risk Factors, Time Factors, Young Adult},
pages = {151--155},
}
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METHODS: Sixty-six physicians accepted to participate from 50 French Infectious Diseases and Geriatrics Departments. From May to September 2014, patients treated at least one day with SC antibiotics could be included. Modalities of subcutaneous administration, occurrence of local and systemic adverse effects (AE) and clinical course were collected until the end of the treatment. RESULTS: Two hundred-nineteen patients (83.0 [19–104] yo) were included. Ceftriaxone (n = 163, 74.4%), and ertapenem (n = 30, 13.7%) were the most often prescribed antibiotics. The SC route was mainly used because of poor venous access (65.3%) and/or palliative care (32.4%). Fifty patients (22.8%) experienced at least one local AE that led to an increased hospital stay for two patients (4.0%) and a discontinuation of the SC infusion in six patients (12.0%). A binary logistic regression for multivariate analysis identified the class of antibiotic (p = 0.002) especially teicoplanin and the use of rigid catheter (p = 0.009) as factors independently associated with AE. In over 80% of cases, SC antibiotics were well tolerated and associated with clinical recovery. CONCLUSIONS: SC administration of antibiotics leads to frequent but local and mild AE. Use of non-rigid catheter appears to be protective against AE. As it appears to be a safe alternative to the intravenous route, more studies are needed regarding efficacy and pharmacokinetics.","language":"eng","number":"1","journal":"Age and Ageing","author":[{"propositions":[],"lastnames":["Roubaud-Baudron"],"firstnames":["Claire"],"suffixes":[]},{"propositions":[],"lastnames":["Forestier"],"firstnames":["Emmanuel"],"suffixes":[]},{"propositions":[],"lastnames":["Fraisse"],"firstnames":["Thibaut"],"suffixes":[]},{"propositions":[],"lastnames":["Gaillat"],"firstnames":["Jacques"],"suffixes":[]},{"propositions":["de"],"lastnames":["Wazières"],"firstnames":["Benoit"],"suffixes":[]},{"propositions":[],"lastnames":["Pagani"],"firstnames":["Leonardo"],"suffixes":[]},{"propositions":[],"lastnames":["Ingrand"],"firstnames":["Isabelle"],"suffixes":[]},{"propositions":[],"lastnames":["Bernard"],"firstnames":["Louis"],"suffixes":[]},{"propositions":[],"lastnames":["Gavazzi"],"firstnames":["Gaëtan"],"suffixes":[]},{"propositions":[],"lastnames":["Paccalin"],"firstnames":["Marc"],"suffixes":[]}],"month":"January","year":"2017","pmid":"28181635","keywords":"Adult, Aged, Aged, 80 and over, Anti-Bacterial Agents, Bacterial Infections, Catheters, Drug Administration Schedule, Drug-Related Side Effects and Adverse Reactions, Equipment Design, Female, France, Humans, Infusions, Subcutaneous, Logistic Models, Male, Middle Aged, Multivariate Analysis, Odds Ratio, Prospective Studies, Risk Factors, Time Factors, Young Adult","pages":"151–155","bibtex":"@article{roubaud-baudron_tolerance_2017,\n\ttitle = {Tolerance of subcutaneously administered antibiotics: a {French} national prospective study},\n\tvolume = {46},\n\tissn = {1468-2834},\n\tshorttitle = {Tolerance of subcutaneously administered antibiotics},\n\tdoi = {10.1093/ageing/afw143},\n\tabstract = {BACKGROUND/ OBJECTIVE: Although poorly documented, subcutaneous (SC) administration of antibiotics is common practice in France especially in Geriatrics Departments. The aim of this study was to determine the tolerance of such a practice.\nDESIGN: Prospective observational multicentre study.\nMETHODS: Sixty-six physicians accepted to participate from 50 French Infectious Diseases and Geriatrics Departments. From May to September 2014, patients treated at least one day with SC antibiotics could be included. Modalities of subcutaneous administration, occurrence of local and systemic adverse effects (AE) and clinical course were collected until the end of the treatment.\nRESULTS: Two hundred-nineteen patients (83.0 [19–104] yo) were included. Ceftriaxone (n = 163, 74.4\\%), and ertapenem (n = 30, 13.7\\%) were the most often prescribed antibiotics. The SC route was mainly used because of poor venous access (65.3\\%) and/or palliative care (32.4\\%). Fifty patients (22.8\\%) experienced at least one local AE that led to an increased hospital stay for two patients (4.0\\%) and a discontinuation of the SC infusion in six patients (12.0\\%). A binary logistic regression for multivariate analysis identified the class of antibiotic (p = 0.002) especially teicoplanin and the use of rigid catheter (p = 0.009) as factors independently associated with AE. In over 80\\% of cases, SC antibiotics were well tolerated and associated with clinical recovery.\nCONCLUSIONS: SC administration of antibiotics leads to frequent but local and mild AE. Use of non-rigid catheter appears to be protective against AE. As it appears to be a safe alternative to the intravenous route, more studies are needed regarding efficacy and pharmacokinetics.},\n\tlanguage = {eng},\n\tnumber = {1},\n\tjournal = {Age and Ageing},\n\tauthor = {Roubaud-Baudron, Claire and Forestier, Emmanuel and Fraisse, Thibaut and Gaillat, Jacques and de Wazières, Benoit and Pagani, Leonardo and Ingrand, Isabelle and Bernard, Louis and Gavazzi, Gaëtan and Paccalin, Marc},\n\tmonth = jan,\n\tyear = {2017},\n\tpmid = {28181635},\n\tkeywords = {Adult, Aged, Aged, 80 and over, Anti-Bacterial Agents, Bacterial Infections, Catheters, Drug Administration Schedule, Drug-Related Side Effects and Adverse Reactions, Equipment Design, Female, France, Humans, Infusions, Subcutaneous, Logistic Models, Male, Middle Aged, Multivariate Analysis, Odds Ratio, Prospective Studies, Risk Factors, Time Factors, Young Adult},\n\tpages = {151--155},\n}\n\n","author_short":["Roubaud-Baudron, C.","Forestier, E.","Fraisse, T.","Gaillat, J.","de Wazières, B.","Pagani, L.","Ingrand, I.","Bernard, L.","Gavazzi, G.","Paccalin, M."],"key":"roubaud-baudron_tolerance_2017","id":"roubaud-baudron_tolerance_2017","bibbaseid":"roubaudbaudron-forestier-fraisse-gaillat-dewazires-pagani-ingrand-bernard-etal-toleranceofsubcutaneouslyadministeredantibioticsafrenchnationalprospectivestudy-2017","role":"author","urls":{},"keyword":["Adult","Aged","Aged","80 and over","Anti-Bacterial Agents","Bacterial Infections","Catheters","Drug Administration Schedule","Drug-Related Side Effects and Adverse Reactions","Equipment Design","Female","France","Humans","Infusions","Subcutaneous","Logistic Models","Male","Middle Aged","Multivariate Analysis","Odds Ratio","Prospective Studies","Risk Factors","Time Factors","Young Adult"],"metadata":{"authorlinks":{}},"downloads":0,"html":""},"bibtype":"article","biburl":"https://bibbase.org/zotero/ginger_infectio-geriatrie","dataSources":["X68xDdTfwewdKzZkp"],"keywords":["adult","aged","aged","80 and over","anti-bacterial agents","bacterial infections","catheters","drug administration schedule","drug-related side effects and adverse reactions","equipment design","female","france","humans","infusions","subcutaneous","logistic models","male","middle aged","multivariate analysis","odds ratio","prospective studies","risk factors","time factors","young adult"],"search_terms":["tolerance","subcutaneously","administered","antibiotics","french","national","prospective","study","roubaud-baudron","forestier","fraisse","gaillat","de wazières","pagani","ingrand","bernard","gavazzi","paccalin"],"title":"Tolerance of subcutaneously administered antibiotics: a French national prospective study","year":2017}