Impact of age and gender interaction on circulating endothelial progenitor cells in healthy subjects. Rousseau, A., Ayoubi, F., Deveaux, C., Charbit, B., Delmau, C., Christin-Maitre, S., Jaillon, P., Uzan, G., & Simon, T. Fertil Steril, 93(3):843–6, 2010.
Impact of age and gender interaction on circulating endothelial progenitor cells in healthy subjects [link]Paper  abstract   bibtex   
OBJECTIVE: To assess the level of circulating endothelial progenitor cells (CEPC) in cycling women compared with men and menopausal women. DESIGN: Controlled clinical study. SETTING: Healthy, nonsmoking volunteers. PATIENT(S): Twelve women, aged 18-40 years, with regular menstrual cycles, 12 menopausal women, and two groups of 12 age-matched men were recruited. Women did not receive any hormone therapy. INTERVENTION(S): Collection of 20 mL of peripheral blood. MAIN OUTCOME MEASURE(S): The number of CEPC, defined as (Lin-/7AAD-/CD34+/CD133+/KDR+) cells per 10(6) mononuclear cells (MNC), was measured by flow cytometry. RESULT(S): The number of CEPC was significantly higher in cycling women than in age-matched men and menopausal women (26.5 per 10(6) MNC vs. 10.5 per 10(6) MNC vs. 10 per 10(6) MNC, respectively). The number of CEPC was similar in menopausal women, age-matched, and young men. CONCLUSION(S): The number of CEPC is influenced by an age-gender interaction. This phenomenon may explain in part the better vascular repair and relative cardiovascular protection in younger women as compared with age-matched men.
@article{rousseau_impact_2010,
	title = {Impact of age and gender interaction on circulating endothelial progenitor cells in healthy subjects},
	volume = {93},
	issn = {1556-5653},
	shorttitle = {Impact of age and gender interaction on circulating endothelial progenitor cells in healthy subjects},
	url = {http://dx.doi.org/10.1016/j.fertnstert.2008.10.062},
	abstract = {OBJECTIVE: To assess the level of circulating endothelial progenitor cells (CEPC) in cycling women compared with men and menopausal women. DESIGN: Controlled clinical study. SETTING: Healthy, nonsmoking volunteers. PATIENT(S): Twelve women, aged 18-40 years, with regular menstrual cycles, 12 menopausal women, and two groups of 12 age-matched men were recruited. Women did not receive any hormone therapy. INTERVENTION(S): Collection of 20 mL of peripheral blood. MAIN OUTCOME MEASURE(S): The number of CEPC, defined as (Lin-/7AAD-/CD34+/CD133+/KDR+) cells per 10(6) mononuclear cells (MNC), was measured by flow cytometry. RESULT(S): The number of CEPC was significantly higher in cycling women than in age-matched men and menopausal women (26.5 per 10(6) MNC vs. 10.5 per 10(6) MNC vs. 10 per 10(6) MNC, respectively). The number of CEPC was similar in menopausal women, age-matched, and young men. CONCLUSION(S): The number of CEPC is influenced by an age-gender interaction. This phenomenon may explain in part the better vascular repair and relative cardiovascular protection in younger women as compared with age-matched men.},
	number = {3},
	journal = {Fertil Steril},
	author = {Rousseau, Alexandra and Ayoubi, Fida and Deveaux, Christel and Charbit, Beny and Delmau, Catherine and Christin-Maitre, Sophie and Jaillon, Patrice and Uzan, Georges and Simon, Tabassome},
	year = {2010},
	pages = {843--6}
}

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