Developmental genetics of vertebrate glial-cell specification. Rowitch, D. H & Kriegstein, A. R Nature, 468(7321):214–222, England, November, 2010. abstract bibtex Oligodendrocytes and astrocytes are macroglial cells of the vertebrate central nervous system. These cells have diverse roles in the maintenance of neurological function. In the embryo, the genetic mechanisms that underlie the specification of macroglial precursors in vivo appear strikingly similar to those that regulate the development of the diverse neuron types. The switch from producing neuronal to glial subtype-specific precursors can be modelled as an interplay between region-restricted components and temporal regulators that determine neurogenic or gliogenic phases of development, contributing to glial diversity. Gaining insight into the developmental genetics of macroglia has great potential to improve our understanding of a variety of neurological disorders in humans.
@ARTICLE{Rowitch2010-rj,
title = "Developmental genetics of vertebrate glial-cell specification",
author = "Rowitch, David H and Kriegstein, Arnold R",
abstract = "Oligodendrocytes and astrocytes are macroglial cells of the
vertebrate central nervous system. These cells have diverse roles
in the maintenance of neurological function. In the embryo, the
genetic mechanisms that underlie the specification of macroglial
precursors in vivo appear strikingly similar to those that
regulate the development of the diverse neuron types. The switch
from producing neuronal to glial subtype-specific precursors can
be modelled as an interplay between region-restricted components
and temporal regulators that determine neurogenic or gliogenic
phases of development, contributing to glial diversity. Gaining
insight into the developmental genetics of macroglia has great
potential to improve our understanding of a variety of
neurological disorders in humans.",
journal = "Nature",
volume = 468,
number = 7321,
pages = "214--222",
month = nov,
year = 2010,
address = "England",
language = "en"
}
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