Developmental genetics of vertebrate glial-cell specification. Rowitch, D. H & Kriegstein, A. R Nature, 468(7321):214–222, England, November, 2010.
abstract   bibtex   
Oligodendrocytes and astrocytes are macroglial cells of the vertebrate central nervous system. These cells have diverse roles in the maintenance of neurological function. In the embryo, the genetic mechanisms that underlie the specification of macroglial precursors in vivo appear strikingly similar to those that regulate the development of the diverse neuron types. The switch from producing neuronal to glial subtype-specific precursors can be modelled as an interplay between region-restricted components and temporal regulators that determine neurogenic or gliogenic phases of development, contributing to glial diversity. Gaining insight into the developmental genetics of macroglia has great potential to improve our understanding of a variety of neurological disorders in humans.
@ARTICLE{Rowitch2010-rj,
  title    = "Developmental genetics of vertebrate glial-cell specification",
  author   = "Rowitch, David H and Kriegstein, Arnold R",
  abstract = "Oligodendrocytes and astrocytes are macroglial cells of the
              vertebrate central nervous system. These cells have diverse roles
              in the maintenance of neurological function. In the embryo, the
              genetic mechanisms that underlie the specification of macroglial
              precursors in vivo appear strikingly similar to those that
              regulate the development of the diverse neuron types. The switch
              from producing neuronal to glial subtype-specific precursors can
              be modelled as an interplay between region-restricted components
              and temporal regulators that determine neurogenic or gliogenic
              phases of development, contributing to glial diversity. Gaining
              insight into the developmental genetics of macroglia has great
              potential to improve our understanding of a variety of
              neurological disorders in humans.",
  journal  = "Nature",
  volume   =  468,
  number   =  7321,
  pages    = "214--222",
  month    =  nov,
  year     =  2010,
  address  = "England",
  language = "en"
}

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