@article{roy_i-tasser:_2010,
	title = {I-{TASSER}: a unified platform for automated protein structure and function prediction},
	volume = {5},
	copyright = {© 2010 Nature Publishing Group},
	issn = {1754-2189},
	shorttitle = {I-{TASSER}},
	url = {http://www.nature.com/nprot/journal/v5/n4/abs/nprot.2010.5.html},
	doi = {10.1038/nprot.2010.5},
	abstract = {The iterative threading assembly refinement (I-TASSER) server is an integrated platform for automated protein structure and function prediction based on the sequence-to-structure-to-function paradigm. Starting from an amino acid sequence, I-TASSER first generates three-dimensional (3D) atomic models from multiple threading alignments and iterative structural assembly simulations. The function of the protein is then inferred by structurally matching the 3D models with other known proteins. The output from a typical server run contains full-length secondary and tertiary structure predictions, and functional annotations on ligand-binding sites, Enzyme Commission numbers and Gene Ontology terms. An estimate of accuracy of the predictions is provided based on the confidence score of the modeling. This protocol provides new insights and guidelines for designing of online server systems for the state-of-the-art protein structure and function predictions. The server is available at http://zhanglab.ccmb.med.umich.edu/I-TASSER.},
	language = {en},
	number = {4},
	urldate = {2013-03-11TZ},
	journal = {Nature Protocols},
	author = {Roy, Ambrish and Kucukural, Alper and Zhang, Yang},
	month = apr,
	year = {2010},
	keywords = {Antibodies, Biophysics, Biotechnology, Computational Biology, DNA sequencing, Ecology, Electrophysiology, Gene expression, Genomics, Histology, Marine Biology, Methods, Molecular Biology, Mutagenesis, Nanotechnology, Nature Protocols, Physiology, Protein Engineering, Proteins, Proteomics, RNA isolation, Recombinant Proteins, analytical chemistry, animal cells, biochemistry, bioinformatics, biological chemistry, biology articles, biology projects., biomedical, cell biology, cell signalling, chemistry, computational chemistry, conservation biology, developmental biology, drug discovery, endocrinology, evolutionary biology, forensics, genetics, glycomics, immunology, laboratory, life sciences, metabolomics/metabonomics, methodology, microarrays, microbiology, microscopy, nature, nature journals, nature magazines, neuroscience, parasitology, pharmacology, plant biology, plant science, protein synthesis, protocols, purification, rational drug design, recombinant DNA, research papers, science, science and nature, science and technology, science experiments, science research, science research papers, sequencing, spectroscopy, stem cell research, structural biology, systems biology, techniques, toxicology, transduction, transfection, zoology},
	pages = {725--738}
}

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