Natural history of gastro-oesophageal reflux disease diagnosed in general practice. Ruigómez, A., García Rodríguez, L. A., Wallander, M., Johansson, S., Graffner, H., & Dent, J. Alimentary Pharmacology & Therapeutics, 20(7):751--760, October, 2004.
doi  abstract   bibtex   
BACKGROUND: Cross-sectional studies indicate that gastro-oesophageal reflux disease symptoms have a prevalence of 10-20% in Western countries and are associated with obesity, smoking, oesophagitis, chest pain and respiratory disease. AIM: To determine the natural history of gastro-oesophageal reflux disease presenting in primary care in the UK. METHODS: Patients with a first diagnosis of gastro-oesophageal reflux disease during 1996 were identified in the UK General Practice Research Database and compared with age- and sex-matched controls. We investigated the incidence of gastro-oesophageal reflux disease, potential risk factors and comorbidities, and relative risk for subsequent oesophageal complications and mortality. RESULTS: The incidence of a gastro-oesophageal reflux disease diagnosis was 4.5 per 1000 person-years (95% confidence interval: 4.4-4.7). Prior use of non-steroidal anti-inflammatory drugs, smoking, excess body weight and gastrointestinal and cardiac conditions were associated with an increased risk of gastro-oesophageal reflux disease diagnosis. Subjects with gastro-oesophageal reflux disease had an increased risk of respiratory problems, chest pain and angina in the year after diagnosis, and had a relative risk of 11.5 (95% confidence interval: 5.9-22.3) of being diagnosed with an oesophageal complication. There was an increase in mortality in the gastro-oesophageal reflux disease cohort only in the year following the diagnosis. CONCLUSIONS: Gastro-oesophageal reflux disease is a disease associated with a range of potentially serious oesophageal complications and extra-oesophageal diseases.
@article{ruigomez_natural_2004,
	title = {Natural history of gastro-oesophageal reflux disease diagnosed in general practice},
	volume = {20},
	issn = {0269-2813},
	doi = {10.1111/j.1365-2036.2004.02169.x},
	abstract = {BACKGROUND: Cross-sectional studies indicate that gastro-oesophageal reflux disease symptoms have a prevalence of 10-20\% in Western countries and are associated with obesity, smoking, oesophagitis, chest pain and respiratory disease.
AIM: To determine the natural history of gastro-oesophageal reflux disease presenting in primary care in the UK.
METHODS: Patients with a first diagnosis of gastro-oesophageal reflux disease during 1996 were identified in the UK General Practice Research Database and compared with age- and sex-matched controls. We investigated the incidence of gastro-oesophageal reflux disease, potential risk factors and comorbidities, and relative risk for subsequent oesophageal complications and mortality.
RESULTS: The incidence of a gastro-oesophageal reflux disease diagnosis was 4.5 per 1000 person-years (95\% confidence interval: 4.4-4.7). Prior use of non-steroidal anti-inflammatory drugs, smoking, excess body weight and gastrointestinal and cardiac conditions were associated with an increased risk of gastro-oesophageal reflux disease diagnosis. Subjects with gastro-oesophageal reflux disease had an increased risk of respiratory problems, chest pain and angina in the year after diagnosis, and had a relative risk of 11.5 (95\% confidence interval: 5.9-22.3) of being diagnosed with an oesophageal complication. There was an increase in mortality in the gastro-oesophageal reflux disease cohort only in the year following the diagnosis.
CONCLUSIONS: Gastro-oesophageal reflux disease is a disease associated with a range of potentially serious oesophageal complications and extra-oesophageal diseases.},
	language = {eng},
	number = {7},
	journal = {Alimentary Pharmacology \& Therapeutics},
	author = {Ruigómez, A. and García Rodríguez, L. A. and Wallander, M.-A. and Johansson, S. and Graffner, H. and Dent, J.},
	month = oct,
	year = {2004},
	pmid = {15379835},
	keywords = {Adolescent, Adult, Aged, Anti-Inflammatory Agents, Non-Steroidal, Antirheumatic Agents, Child, Child, Preschool, Cohort Studies, Family Practice, Female, Gastroesophageal Reflux, Great Britain, Humans, Infant, Male, Middle Aged, Nitrates, Patient Acceptance of Health Care, Risk Factors, Steroids},
	pages = {751--760}
}

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