@article{ruigomez_irritable_2009,
	title = {Irritable bowel syndrome and gastroesophageal reflux disease in primary care: is there a link?},
	volume = {54},
	issn = {1573-2568},
	shorttitle = {Irritable bowel syndrome and gastroesophageal reflux disease in primary care},
	doi = {10.1007/s10620-008-0462-0},
	abstract = {Population-based studies have shown that gastroesophageal reflux disease (GERD) and irritable bowel syndrome (IBS) coexist more commonly than expected by chance. We aimed to investigate the relationship between GERD and IBS in primary care. The General Practice Research Database was used to identify patients with a first diagnosis of GERD (n=6,421) or IBS (n=2,932). Patients were followed up for 12 months after diagnosis to investigate the incidence of IBS among GERD patients and GERD among IBS patients. The relative risk (RR) of developing IBS was 3.5 (95\% CI: 2.3-5.4) in the GERD cohort compared with the comparison cohort. The RR of developing GERD was 2.8 (95\% CI: 1.7-4.9) in the IBS cohort compared with the comparison cohort. A first diagnosis of either IBS or GERD significantly increases the risk of a subsequent diagnosis of the other condition.},
	language = {eng},
	number = {5},
	journal = {Digestive Diseases and Sciences},
	author = {Ruigómez, Ana and Wallander, Mari-Ann and Johansson, Saga and Rodríguez, Luis Alberto García},
	month = may,
	year = {2009},
	pmid = {18720002},
	keywords = {Adult, Age Distribution, Aged, Comorbidity, Female, Gastroesophageal Reflux, Great Britain, Health Surveys, Humans, Irritable Bowel Syndrome, Longitudinal Studies, Male, Middle Aged, Odds Ratio, Primary Health Care, Risk Assessment, Risk Factors, Sex Distribution, Time Factors, Young Adult, databases as topic, incidence},
	pages = {1079--1086}
}

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We aimed to investigate the relationship between GERD and IBS in primary care. The General Practice Research Database was used to identify patients with a first diagnosis of GERD (n=6,421) or IBS (n=2,932). Patients were followed up for 12 months after diagnosis to investigate the incidence of IBS among GERD patients and GERD among IBS patients. The relative risk (RR) of developing IBS was 3.5 (95% CI: 2.3-5.4) in the GERD cohort compared with the comparison cohort. The RR of developing GERD was 2.8 (95% CI: 1.7-4.9) in the IBS cohort compared with the comparison cohort. 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