@ARTICLE{Ruiz2017,
author={Ruiz, D. and del Rosal, B. and Acebrón, M. and Palencia, C. and Sun, C. and Cabanillas-González, J. and López-Haro, M. and Hungría, A.B. and Jaque, D. and Juarez, B.H.},
title={Ag/Ag2S Nanocrystals for High Sensitivity Near-Infrared Luminescence Nanothermometry},
journal={Advanced Functional Materials},
year={2017},
volume={27},
number={6},
doi={10.1002/adfm.201604629},
art_number={1604629},
note={cited By 48},
url={https://www.scopus.com/inward/record.uri?eid=2-s2.0-85008430088&doi=10.1002%2fadfm.201604629&partnerID=40&md5=4c7c54a7e7e99d6eefd0537451479a0a},
abstract={Temperature sensing in biological media (cells, tissues, and living organisms) has become essential in the development of the last generation of diagnostics and therapeutic strategies. Thermometry can be used for early detection of different diseases, such as cancer, stroke, or inflammation processes, one of whose incipient symptoms is the appearance of localized temperature singularities. Luminescence nanothermometry, as a tool to accurately provide temperature sensing in biological media, requires the rational design and development of nanothermometers operating in the second biological window. In this work, this is achieved using Ag/Ag2S nanocrystals as multiparametric thermal sensing probes. Temperature sensing with remarkably high sensitivity (4% °C−1) is possible through intensity-based measurements, as their infrared emission is strongly quenched by small temperature variations within the biological range (15–50 °C). Heating also results in a remarkable redshift of the emission band, which allows for concentration-independent temperature sensing based on infrared ratiometric measurements, with thermal sensitivity close to 2% °C−1. These results make Ag/Ag2S nanocrystals the most sensitive among all noncomposite nanothermometers operating in the second biological window reported so far, allowing for deep-tissue temperature measurements with low uncertainty (0.2 °C). © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim},
keywords={Biology;  Diagnosis;  Infrared devices;  Infrared radiation;  Luminescence;  Nanocrystals;  Sensitivity analysis;  Silver compounds;  Temperature measurement;  Temperature sensors;  Tissue;  Uncertainty analysis, Infrared emissions;  Living organisms;  Localized temperature;  Near infrared luminescence;  Small temperature variation;  Temperature sensing;  Therapeutic strategy;  Thermal sensitivity, Sulfur compounds},
document_type={Article},
source={Scopus},
}

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