Alterations of the proton-T2 time in relaxed skeletal muscle induced by passive extremity flexions. Rump, J.; Braun, J.; Papazoglou, S.; Taupitz, M.; Sack; and c, I. Journal of Magnetic Resonance Imaging, 23(4):541-546, 2006. cited By (since 1996)5
Alterations of the proton-T2 time in relaxed skeletal muscle induced by passive extremity flexions [link]Paper  doi  abstract   bibtex   
Purpose: To demonstrate reciprocal changes of the apparent proton-T2 time in the biceps and triceps due to passive contraction and extension of the muscle fibers. Materials and Methods: The contraction state of the upper arm muscles of six healthy volunteers was passively changed by alternating the forearm position between the straight-arm position and an elbow flexion of 90°. The relaxation of the muscle during passive contraction and extension was measured with the use of muscle electromyography (EMG) experiments. Spin-echo (SE) MRI with increasing echo times (TEs) of 12-90 msec was used to acquire the averaged signal decay of the segmented biceps and triceps. The apparent T2 was deduced using monoexponential least-square fitting. Results: The median T2 alterations in biceps and triceps among all volunteers were found to be 1.2 and -1.3 msec in the straight and bent forearm positions, respectively. The confidence intervals (0.5 to 1.7 msec in biceps, and -2.6 to -1.1 msec in triceps) clearly indicate that proton-T2 in MR : images Is significantly (P < 0.05) prolonged with muscle contraction. Conclusion: The observed increase of the proton-T2 time was correlated with a passive contraction of skeletal muscle fibers. This passive effect can be attributed to changes in the intracellular water mobility corresponding to the well-known "active" T2 increase that occurs after stimulation of muscle. © 2006 Wiley-Liss, Inc.
@article{ Rump2006541,
  author = {Rump, J.a  and Braun, J.b  and Papazoglou, S.a  and Taupitz, M.a  and Sack, I.a  c },
  title = {Alterations of the proton-T2 time in relaxed skeletal muscle induced by passive extremity flexions},
  journal = {Journal of Magnetic Resonance Imaging},
  year = {2006},
  volume = {23},
  number = {4},
  pages = {541-546},
  note = {cited By (since 1996)5},
  url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-33645677712&partnerID=40&md5=06e97acec1424a0be7760baed5dd78e3},
  affiliation = {Institute of Radiology, Charité-University Medicine Berlin, Berlin, Germany; Institute of Medical Informatics, Charité-University Medicine Berlin, Berlin, Germany; Institute of Radiology, Charité-University Medicine Berlin, Humboldt University Berlin, Schumannstr. 20/21, 10117 Berlin, Germany},
  abstract = {Purpose: To demonstrate reciprocal changes of the apparent proton-T2 time in the biceps and triceps due to passive contraction and extension of the muscle fibers. Materials and Methods: The contraction state of the upper arm muscles of six healthy volunteers was passively changed by alternating the forearm position between the straight-arm position and an elbow flexion of 90°. The relaxation of the muscle during passive contraction and extension was measured with the use of muscle electromyography (EMG) experiments. Spin-echo (SE) MRI with increasing echo times (TEs) of 12-90 msec was used to acquire the averaged signal decay of the segmented biceps and triceps. The apparent T2 was deduced using monoexponential least-square fitting. Results: The median T2 alterations in biceps and triceps among all volunteers were found to be 1.2 and -1.3 msec in the straight and bent forearm positions, respectively. The confidence intervals (0.5 to 1.7 msec in biceps, and -2.6 to -1.1 msec in triceps) clearly indicate that proton-T2 in MR : images Is significantly (P &lt; 0.05) prolonged with muscle contraction. Conclusion: The observed increase of the proton-T2 time was correlated with a passive contraction of skeletal muscle fibers. This passive effect can be attributed to changes in the intracellular water mobility corresponding to the well-known "active" T2 increase that occurs after stimulation of muscle. © 2006 Wiley-Liss, Inc.},
  author_keywords = {Diffusion;  Muscle contraction;  Relaxometry;  Skeletal muscle MRI;  T2;  Water mobility},
  keywords = {article;  biceps brachii muscle;  electromyography;  human;  human experiment;  muscle blood flow;  muscle contraction;  muscle relaxation;  normal human;  oxygen blood level;  passive movement;  priority journal;  proton nuclear magnetic resonance;  skeletal muscle;  triceps brachii muscle;  volunteer;  arm;  body posture;  image processing;  methodology;  muscle contraction;  muscle isometric contraction;  nonparametric test;  nuclear magnetic resonance imaging;  physiology, proton, Humans;  Image Processing, Computer-Assisted;  Isometric Contraction;  Magnetic Resonance Imaging;  Muscle Contraction;  Muscle, Skeletal;  Prone Position;  Protons;  Statistics, Nonparametric;  Upper Extremity},
  chemicals_cas = {proton, 12408-02-5, 12586-59-3; Protons},
  references = {Bratton, C.B., Hopkins, A.L., Weinberg, J.W., Nuclear magnetic resonance studies of living muscle (1965) Science, 147, pp. 738-739; Fleckenstein, J.L., Canby, R.C., Parkey, R.W., Peshock, R.M., Acute effects of exercise on MR imaging of skeletal muscle in normal volunteers (1988) AJR Am J Roentgenol, 151, pp. 231-237; Fisher, M.J., Meyer, R.A., Adams, G.R., Foley, J.M., Potchen, E.J., Direct relationship between proton T2 and exercise intensity in skeletal muscle MR images (1990) Invest Radiol, 25, pp. 480-485; Adams, G.R., Duvoisin, M.R., Dudley, G.A., Magnetic resonance imaging and electromyography as indexes of muscle function (1992) J Appl Physiol, 73, pp. 1578-1583; Conley, M.S., Foley, J.M., Ploutz-Snyder, L.L., Meyer, R.A., Dudley, G.A., Effect of acute head-down tilt on skeletal muscle cross-sectional area and proton transverse relaxation time (1996) J Appl Physiol, 81, pp. 1572-1577; Cheng, H.A., Robergs, R.A., Letellier, J.P., Caprihan, A., Icenogle, M.V., Haseler, L.J., Changes in muscle proton transverse relaxation times and acidosis during exercise and recovery (1995) J Appl Physiol, 79, pp. 1370-1378; Disler, D.G., Cohen, M.S., Krebs, D.E., Roy, S.H., Rosenthal, D.I., Dynamic evaluation of exercising leg muscle in healthy subjects with echo planar MR imaging: Work rate and total work determine rate of T2 change (1995) J Magn Reson Imaging, 5, pp. 588-593; Ploutz-Snyder, L.L., Nyren, S., Cooper, T.G., Potchen, E.J., Meyer, R.A., Different effects of exercise and edema on T2 relaxation in skeletal muscle (1997) Magn Reson Med, 37, pp. 676-682; Hardy, P.A., Yue, G., Measurement of magnetic resonance T2 for physiological experiments (1997) J Appl Physiol, 83, pp. 904-911; Fleckenstein, J.L., Watumull, D., McIntire, D.D., Bertocci, L.A., Chason, D.P., Peshock, R.M., Muscle proton T2 relaxation times and work during repetitive maximal voluntary exercise (1993) J Appl Physiol, 74, pp. 2855-2859; Yue, G., Alexander, A.L., Laidlaw, D.H., Gmitro, A.F., Unger, E.C., Enoka, R.M., Sensitivity of muscle proton spin-spin relaxation time as an index of muscle activation (1994) J Appl Physiol, 77, pp. 84-92; Weidman, E.R., Charles, H.C., Negro-Vilar, R., Sullivan, M.J., MacFall, J.R., Muscle activity localization with 31P spectroscopy and calculated T2-weighted 1H images (1991) Invest Radiol, 26, pp. 309-316; Richardson, R.S., Frank, L.R., Haseler, L.J., Dynamic knee-extensor and cycle exercise: Functional MR1 of muscular activity (1998) Int J Sports Med, 19, pp. 182-187; Akima, H., Kuno, S., Takahashi, H., Fukunaga, T., Katsuta, S., The use of magnetic resonance images to investigate the influence of recruitment on the relationship between torque and cross-sectional area in human muscle (2000) Eur J Appl Physiol, 83, pp. 475-480; Takeda, Y., Kashiwaguchi, S., Endo, K., Matsuura, T., Sasa, T., The most effective exercise for strengthening the supraspinatus muscle: Evaluation by magnetic resonance imaging (2002) Am J Sports Med, 30, pp. 374-381; Le Rumeur, E., De Certaines, J., Toulouse, P., Rochcongar, P., Water phases in rat striated muscles as determined by T2 proton NMR relaxation times (1987) Magn Reson Imaging, 5, pp. 267-272; Hazlewood, C.F., Chang, D.C., Nichols, B.L., Woessner, D.E., Nuclear magnetic resonance transverse relaxation times of water protons in skeletal muscle (1974) Biophys J, 14, pp. 583-606; Saab, G., Thompson, R.T., Marsh, G.D., Multicomponent T2 relaxation of in vivo skeletal muscle (1999) Magn Reson Med, 42, pp. 150-157; Adzamli, I.K., Jolesz, F.A., Bleier, A.R., Mulkern, R.V., Sandor, T., The effect of gadolinium DTPA on tissue water compartments in slow- and fast-twitch rabbit muscles (1989) Magn Reson Med, 11, pp. 172-181; Stainsby, J.A., Wright, G.A., Monitoring blood oxygen state in muscle microcirculation with transverse relaxation (2001) Magn Reson Med, 45, pp. 662-672; Gambarota, G., Calms, B.E., Berde, C.B., Mulkem, R.V., Osmotic effects on the T2 relaxation decay of in vivo muscle (2001) Magn Reson Med, 46, pp. 592-599; Donahue, K.M., Weisskoff, R.M., Chester, D.A., Improving MR quantification of regional blood volume with intravascular T1 contrast agents: Accuracy, precision, and water exchange (1996) Magn Reson Med, 36, pp. 858-867; Schwarzbauer, C., Syha, J., Haase, A., Quantification of regional blood volumes by rapid T1 mapping (1993) Magn Reson Med, 29, pp. 709-712; Archer, B.T., Fleckenstein, J.L., Bertocci, L.A., Effect of perfusion on exercised muscle: MR imaging evaluation (1992) J Magn Reson Imaging, 2, pp. 407-413; Fleckenstein, J.L., Haller, R.G., Bertocci, L.A., Parkey, R.W., Peshock, R.M., Glycogenolysis, not perfusion, is the critical mediator of exercise-induced muscle modifications on MR images (1992) Radiology, 183, pp. 25-26. , discussion 26-27; Jordan, B.F., Kimpalou, J.Z., Beghein, N., Dessy, C., Feron, O., Gallez, B., Contribution of oxygenation to BOLD contrast in exercising muscle (2004) Magn Reson Med, 52, pp. 391-396; Saab, G., Thompson, R.T., Marsh, G.D., Effects of exercise on muscle transverse relaxation determined by MR imaging and in vivo relaxometry (2000) J Appl Physiol, 88, pp. 226-233; Hennig, J., Scheffler, K., Schreiber, A., Time resolved observation of BOLD effect in muscle during isometric exercise (2000) Proceedings of the 8th Annual Meeting of ISMRM, p. 122. , Denver, CO, USA; Meyer, R.A., McCully, K., Reid, R.W., Prior, B., BOLD MRI and NIRS detection of transient hyperemia after single skeletal muscle contractions (2001) Proceedings of the 9th Annual Meeting of ISMRM, p. 135. , Glasgow, Scotland; Towse, T.F., Wiseman, R.W., Meyer, R.A., Field strength dependence of transient BOLD signal changes in skeletal muscle after single contraction (2003) Proceedings of the 11th Annual Meeting of ISMRM, p. 1521. , Toronto, Canada; Fleckenstein, J.L., Haller, R.G., Lewis, S.F., Absence of exercise-induced MRI enhancement of skeletal muscle in McArdle's disease (1991) J Appl Physiol, 71, pp. 961-969; Brownstein, K.R., Tarr, C.E., Importance of classical diffusion in NMR studies of water in biological cells (1979) Phys Rev A, 19, pp. 2446-2453; Slichter, C.P., (1992) Principles of Magnetic Resonance, , Berlin: Springer; Narici, M., Human skeletal muscle architecture studied in vivo by non-invasive imaging techniques: Functional significance and applications (1999) J Electromyogr Kinesiol, 9, pp. 97-103; Vermathen, P., Boesch, C., Kreis, R., Mapping fiber orientation in human muscle by proton MR spectroscopic imaging (2003) Magn Reson Med, 49, pp. 424-432; Schmalbruch, H., (1985) Skeletal Muscle, , Berlin/Heidelberg: Springer. 440 p; Brown, R.J.S., Information available and unavailable from multiexponential relaxation data (1989) J Magn Reson, 82, pp. 539-561; Morvan, D., Leroy-Willig, A., Simultaneous measurements of diffusion and transverse relaxation in exercising skeletal muscle (1995) Magn Reson Imaging, 13, pp. 943-948},
  correspondence_address1 = {Sack, I.; Institute of Radiology, Charité-University Medicine Berlin, Humboldt University Berlin, Schumannstr. 20/21, 10117 Berlin, Germany; email: ingolf.sack@charite.de},
  issn = {10531807},
  coden = {JMRIF},
  doi = {10.1002/jmri.20534},
  pubmed_id = {16514596},
  language = {English},
  abbrev_source_title = {J. Magn. Reson. Imaging},
  document_type = {Article},
  source = {Scopus}
}
Downloads: 0