Alcohol consumption and cognitive decline in early old age. Sabia, S., Elbaz, A., Britton, A., Bell, S., Dugravot, A., Shipley, M., Kivimaki, M., & Singh-Manoux, A. Neurology, 82(4):332–339, January, 2014.
Alcohol consumption and cognitive decline in early old age. [link]Paper  doi  abstract   bibtex   
OBJECTIVE:To examine the association between alcohol consumption in midlife and subsequent cognitive decline. METHODS:Data are from 5,054 men and 2,099 women from the Whitehall II cohort study with a mean age of 56 years (range 44-69 years) at first cognitive assessment. Alcohol consumption was assessed 3 times in the 10 years preceding the first cognitive assessment (1997-1999). Cognitive tests were repeated in 2002-2004 and 2007-2009. The cognitive test battery included 4 tests assessing memory and executive function; a global cognitive score summarized performances across these tests. Linear mixed models were used to assess the association between alcohol consumption and cognitive decline, expressed as z scores (mean = 0, SD = 1). RESULTS:In men, there were no differences in cognitive decline among alcohol abstainers, quitters, and light or moderate alcohol drinkers (\textless20 g/d). However, alcohol consumption ${\}ge$36 g/d was associated with faster decline in all cognitive domains compared with consumption between 0.1 and 19.9 g/d: mean difference (95% confidence interval) in 10-year decline in the global cognitive score = -0.10 (-0.16, -0.04), executive function = -0.06 (-0.12, 0.00), and memory = -0.16 (-0.26, -0.05). In women, compared with those drinking 0.1 to 9.9 g/d of alcohol, 10-year abstainers showed faster decline in the global cognitive score (-0.21 [-0.37, -0.04]) and executive function (-0.17 [-0.32, -0.01]). CONCLUSIONS:Excessive alcohol consumption in men (${\}ge$36 g/d) was associated with faster cognitive decline compared with light to moderate alcohol consumption.
@article{sabia_alcohol_2014,
	title = {Alcohol consumption and cognitive decline in early old age.},
	volume = {82},
	url = {http://www.neurology.org/content/82/4/332.full},
	doi = {10.1212/WNL.0000000000000063},
	abstract = {OBJECTIVE:To examine the association between alcohol consumption in midlife and subsequent cognitive decline. METHODS:Data are from 5,054 men and 2,099 women from the Whitehall II cohort study with a mean age of 56 years (range 44-69 years) at first cognitive assessment. Alcohol consumption was assessed 3 times in the 10 years preceding the first cognitive assessment (1997-1999). Cognitive tests were repeated in 2002-2004 and 2007-2009. The cognitive test battery included 4 tests assessing memory and executive function; a global cognitive score summarized performances across these tests. Linear mixed models were used to assess the association between alcohol consumption and cognitive decline, expressed as z scores (mean = 0, SD = 1). RESULTS:In men, there were no differences in cognitive decline among alcohol abstainers, quitters, and light or moderate alcohol drinkers ({\textless}20 g/d). However, alcohol consumption \${\textbackslash}ge\$36 g/d was associated with faster decline in all cognitive domains compared with consumption between 0.1 and 19.9 g/d: mean difference (95\% confidence interval) in 10-year decline in the global cognitive score = -0.10 (-0.16, -0.04), executive function = -0.06 (-0.12, 0.00), and memory = -0.16 (-0.26, -0.05). In women, compared with those drinking 0.1 to 9.9 g/d of alcohol, 10-year abstainers showed faster decline in the global cognitive score (-0.21 [-0.37, -0.04]) and executive function (-0.17 [-0.32, -0.01]). CONCLUSIONS:Excessive alcohol consumption in men (\${\textbackslash}ge\$36 g/d) was associated with faster cognitive decline compared with light to moderate alcohol consumption.},
	language = {English},
	number = {4},
	journal = {Neurology},
	author = {Sabia, Séverine and Elbaz, Alexis and Britton, Annie and Bell, Steven and Dugravot, Aline and Shipley, Martin and Kivimaki, Mika and Singh-Manoux, Archana},
	month = jan,
	year = {2014},
	pmid = {24431298},
	pmcid = {PMC3929201},
	pages = {332--339},
}

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