Non-invasive measurement of brain viscoelasticity using magnetic resonance elastography. Sack, I., Beierbach, B., Hamhaber, U., Klatt, D., & Braun, J.R. NMR Biomed, 21(3):265--271, Mar, 2008. ![Non-invasive measurement of brain viscoelasticity using magnetic resonance elastography. [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex The purpose of this work was to develop magnetic resonance elastography (MRE) for the fast and reproducible measurement of spatially averaged viscoelastic constants of living human brain. The technique was based on a phase-sensitive echo planar imaging acquisition. Motion encoding was orthogonal to the image plane and synchronized to intracranial shear vibrations at driving frequencies of 25 and 50 Hz induced by a head-rocker actuator. Ten time-resolved phase-difference wave images were recorded within 60 s and analyzed for shear stiffness and shear viscosity. Six healthy volunteers (six men; mean age 34.5 years; age range 25-44 years) underwent 23-39 follow-up MRE studies over a period of 6 months. Interindividual mean +/- SD shear moduli and shear viscosities were found to be 1.17 +/- 0.03 kPa and 3.1 +/- 0.4 Pas for 25 Hz and 1.56 +/- 0.07 kPa and 3.4 +/- 0.2 Pas for 50 Hz, respectively (P < or = 0.01). The intraindividual range of shear modulus data was 1.01-1.31 kPa (25 Hz) and 1.33-1.77 kPa (50 Hz). The observed modulus dispersion indicates a limited applicability of Voigt's model to explain viscoelastic behavior of brain parenchyma within the applied frequency range. The narrow distribution of data within small confidence intervals demonstrates excellent reproducibility of the experimental protocol. The results are necessary as reference data for future comparisons between healthy and pathological human brain viscoelastic data.
@article{ Sack2008,
author = {Sack, Ingolf and Beierbach, Bernd and Hamhaber, Uwe and Klatt, Dieter
and Braun, J�rgen},
title = {Non-invasive measurement of brain viscoelasticity using magnetic
resonance elastography.},
journal = {NMR Biomed},
year = {2008},
volume = {21},
pages = {265--271},
number = {3},
month = {Mar},
abstract = {The purpose of this work was to develop magnetic resonance elastography
(MRE) for the fast and reproducible measurement of spatially averaged
viscoelastic constants of living human brain. The technique was based
on a phase-sensitive echo planar imaging acquisition. Motion encoding
was orthogonal to the image plane and synchronized to intracranial
shear vibrations at driving frequencies of 25 and 50 Hz induced by
a head-rocker actuator. Ten time-resolved phase-difference wave images
were recorded within 60 s and analyzed for shear stiffness and shear
viscosity. Six healthy volunteers (six men; mean age 34.5 years;
age range 25-44 years) underwent 23-39 follow-up MRE studies over
a period of 6 months. Interindividual mean +/- SD shear moduli and
shear viscosities were found to be 1.17 +/- 0.03 kPa and 3.1 +/-
0.4 Pas for 25 Hz and 1.56 +/- 0.07 kPa and 3.4 +/- 0.2 Pas for 50
Hz, respectively (P < or = 0.01). The intraindividual range of shear
modulus data was 1.01-1.31 kPa (25 Hz) and 1.33-1.77 kPa (50 Hz).
The observed modulus dispersion indicates a limited applicability
of Voigt's model to explain viscoelastic behavior of brain parenchyma
within the applied frequency range. The narrow distribution of data
within small confidence intervals demonstrates excellent reproducibility
of the experimental protocol. The results are necessary as reference
data for future comparisons between healthy and pathological human
brain viscoelastic data.},
doi = {10.1002/nbm.1189},
institution = {Institute of Radiology, Charit� - Universit�tsmedizin Berlin, Berlin,
Germany.},
keywords = {Adult; Biomechanics; Brain, anatomy /&/ histology/metabolism; Elasticity;
Humans; Image Interpretation, Computer-Assisted; Image Processing,
Computer-Assisted; Magnetic Resonance Imaging, methods; Male; Shear
Strength; Stress, Mechanical; Viscosity},
language = {eng},
medline-pst = {ppublish},
owner = {Heiko},
pmid = {17614101},
timestamp = {2013.07.26},
url = {http://dx.doi.org/10.1002/nbm.1189}
}
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[.1189]\" \n\t class=\"bibbase_icon\"\n\t style=\"width: 24px; height: 24px; border: 0px; vertical-align: text-top\" ><span class=\"bibbase_icon_text\">Paper</span></a> \n \n \n <a href=\"javascript:showBib('Sack2008')\">\n <img src=\"http://www.bibbase.org/img/filetypes/bib.png\" \n\t alt=\"Non-invasive measurement of brain viscoelasticity using magnetic resonance elastography. [bib]\" \n\t class=\"bibbase_icon\"\n\t style=\"width: 24px; height: 24px; border: 0px; vertical-align: text-top\"><span class=\"bibbase_icon_text\">Bibtex</span></a>\n \n \n\n \n \n \n \n \n\n \n <a class=\"bibbase_abstract_link\" href=\"javascript:showAbstract('Sack2008')\">Abstract</a>\n \n \n</span>\n\n<!-- -->\n<!-- <div id=\"abstract_Sack2008\"> -->\n<!-- The purpose of this work was to develop magnetic resonance elastography (MRE) for the fast and reproducible measurement of spatially averaged viscoelastic constants of living human brain. The technique was based on a phase-sensitive echo planar imaging acquisition. Motion encoding was orthogonal to the image plane and synchronized to intracranial shear vibrations at driving frequencies of 25 and 50 Hz induced by a head-rocker actuator. Ten time-resolved phase-difference wave images were recorded within 60 s and analyzed for shear stiffness and shear viscosity. Six healthy volunteers (six men; mean age 34.5 years; age range 25-44 years) underwent 23-39 follow-up MRE studies over a period of 6 months. Interindividual mean +/- SD shear moduli and shear viscosities were found to be 1.17 +/- 0.03 kPa and 3.1 +/- 0.4 Pas for 25 Hz and 1.56 +/- 0.07 kPa and 3.4 +/- 0.2 Pas for 50 Hz, respectively (P < or = 0.01). The intraindividual range of shear modulus data was 1.01-1.31 kPa (25 Hz) and 1.33-1.77 kPa (50 Hz). The observed modulus dispersion indicates a limited applicability of Voigt's model to explain viscoelastic behavior of brain parenchyma within the applied frequency range. The narrow distribution of data within small confidence intervals demonstrates excellent reproducibility of the experimental protocol. The results are necessary as reference data for future comparisons between healthy and pathological human brain viscoelastic data. -->\n<!-- </div> -->\n<!-- -->\n\n</div>\n","downloads":0,"abstract":"The purpose of this work was to develop magnetic resonance elastography (MRE) for the fast and reproducible measurement of spatially averaged viscoelastic constants of living human brain. The technique was based on a phase-sensitive echo planar imaging acquisition. Motion encoding was orthogonal to the image plane and synchronized to intracranial shear vibrations at driving frequencies of 25 and 50 Hz induced by a head-rocker actuator. Ten time-resolved phase-difference wave images were recorded within 60 s and analyzed for shear stiffness and shear viscosity. Six healthy volunteers (six men; mean age 34.5 years; age range 25-44 years) underwent 23-39 follow-up MRE studies over a period of 6 months. Interindividual mean +/- SD shear moduli and shear viscosities were found to be 1.17 +/- 0.03 kPa and 3.1 +/- 0.4 Pas for 25 Hz and 1.56 +/- 0.07 kPa and 3.4 +/- 0.2 Pas for 50 Hz, respectively (P < or = 0.01). The intraindividual range of shear modulus data was 1.01-1.31 kPa (25 Hz) and 1.33-1.77 kPa (50 Hz). The observed modulus dispersion indicates a limited applicability of Voigt's model to explain viscoelastic behavior of brain parenchyma within the applied frequency range. The narrow distribution of data within small confidence intervals demonstrates excellent reproducibility of the experimental protocol. The results are necessary as reference data for future comparisons between healthy and pathological human brain viscoelastic data.","author":["Sack, Ingolf","Beierbach, Bernd","Hamhaber, Uwe","Klatt, Dieter","Braun, J�rgen"],"author_short":["Sack, I.","Beierbach, B.","Hamhaber, U.","Klatt, D.","Braun, J.R."],"bibtex":"@article{ Sack2008,\n author = {Sack, Ingolf and Beierbach, Bernd and Hamhaber, Uwe and Klatt, Dieter\r\n\tand Braun, J�rgen},\n title = {Non-invasive measurement of brain viscoelasticity using magnetic\r\n\tresonance elastography.},\n journal = {NMR Biomed},\n year = {2008},\n volume = {21},\n pages = {265--271},\n number = {3},\n month = {Mar},\n abstract = {The purpose of this work was to develop magnetic resonance elastography\r\n\t(MRE) for the fast and reproducible measurement of spatially averaged\r\n\tviscoelastic constants of living human brain. The technique was based\r\n\ton a phase-sensitive echo planar imaging acquisition. Motion encoding\r\n\twas orthogonal to the image plane and synchronized to intracranial\r\n\tshear vibrations at driving frequencies of 25 and 50 Hz induced by\r\n\ta head-rocker actuator. Ten time-resolved phase-difference wave images\r\n\twere recorded within 60 s and analyzed for shear stiffness and shear\r\n\tviscosity. Six healthy volunteers (six men; mean age 34.5 years;\r\n\tage range 25-44 years) underwent 23-39 follow-up MRE studies over\r\n\ta period of 6 months. Interindividual mean +/- SD shear moduli and\r\n\tshear viscosities were found to be 1.17 +/- 0.03 kPa and 3.1 +/-\r\n\t0.4 Pas for 25 Hz and 1.56 +/- 0.07 kPa and 3.4 +/- 0.2 Pas for 50\r\n\tHz, respectively (P < or = 0.01). The intraindividual range of shear\r\n\tmodulus data was 1.01-1.31 kPa (25 Hz) and 1.33-1.77 kPa (50 Hz).\r\n\tThe observed modulus dispersion indicates a limited applicability\r\n\tof Voigt's model to explain viscoelastic behavior of brain parenchyma\r\n\twithin the applied frequency range. The narrow distribution of data\r\n\twithin small confidence intervals demonstrates excellent reproducibility\r\n\tof the experimental protocol. The results are necessary as reference\r\n\tdata for future comparisons between healthy and pathological human\r\n\tbrain viscoelastic data.},\n doi = {10.1002/nbm.1189},\n institution = {Institute of Radiology, Charit� - Universit�tsmedizin Berlin, Berlin,\r\n\tGermany.},\n keywords = {Adult; Biomechanics; Brain, anatomy /&/ histology/metabolism; Elasticity;\r\n\tHumans; Image Interpretation, Computer-Assisted; Image Processing,\r\n\tComputer-Assisted; Magnetic Resonance Imaging, methods; Male; Shear\r\n\tStrength; Stress, Mechanical; Viscosity},\n language = {eng},\n medline-pst = {ppublish},\n owner = {Heiko},\n pmid = {17614101},\n timestamp = {2013.07.26},\n url = {http://dx.doi.org/10.1002/nbm.1189}\n}","bibtype":"article","doi":"10.1002/nbm.1189","id":"Sack2008","institution":"Institute of Radiology, Charit� - Universit�tsmedizin Berlin, Berlin, Germany.","journal":"NMR Biomed","key":"Sack2008","keywords":"Adult; Biomechanics; Brain, anatomy /&/ histology/metabolism; Elasticity; Humans; Image Interpretation, Computer-Assisted; Image Processing, Computer-Assisted; Magnetic Resonance Imaging, methods; Male; Shear Strength; Stress, Mechanical; Viscosity","language":"eng","medline-pst":"ppublish","month":"Mar","number":"3","owner":"Heiko","pages":"265--271","pmid":"17614101","timestamp":"2013.07.26","title":"Non-invasive measurement of brain viscoelasticity using magnetic resonance elastography.","type":"article","url":"http://dx.doi.org/10.1002/nbm.1189","volume":"21","year":"2008","role":"author","urls":{"Paper":"http://dx.doi.org/10.1002/nbm.1189"},"bibbaseid":"sack-beierbach-hamhaber-klatt-braun-noninvasivemeasurementofbrainviscoelasticityusingmagneticresonanceelastography-2008"},"bibtype":"article","biburl":"http://home.arcor.de/teambushido/Literatur.bib","downloads":0,"title":"Non-invasive measurement of brain viscoelasticity using magnetic resonance elastography.","year":2008,"dataSources":["z828pEjP7GR5ew7B7"]}