Analysis of wave patterns in MR elastography of skeletal muscle using coupled harmonic oscillator simulations. Sack, I.; Bernarding, J.; and Braun, J.R. Magn Reson Imaging, 20(1):95--104, Jan, 2002.
abstract   bibtex   
The ability to study muscle elasticity in vivo would be of great clinical interest. Magnetic resonance elastography (MRE) has the potential to quantify noninvasively the distribution of the shear modulus in muscle tissue. Elasticity information may be derived by extracting frequencies from the wave patterns of phase-contrast MRE images. In a new approach, MRE wave patterns were reconstructed using 3D coupled harmonic oscillator calculations (CHO). To analyze in vivo MRE measurements of the biceps brachii of healthy volunteers, different anisotropic fibrous structures for the couplings between the muscle elements have to be assumed. V-shaped wave patterns as observed when excitation was applied on the tendon were reproduced by a model, where in a central band of stiff fascicles wave propagation was about twice as fast as that in surrounding tissue. Planar waves were observed for excitation near the muscle surface. They could be reconstructed by assuming a simultaneous wave excitation of all muscle fibers, where fibers along the main muscle axis were coupled more strongly than those perpendicular to the axis. The results show that CHO calculations provide a fast and reliable method for incorporating anatomical information of the investigated tissue in the reconstruction of complex wave patterns.
@article{ Sack2002,
  author = {Sack, Ingolf and Bernarding, Johannes and Braun, J�rgen},
  title = {Analysis of wave patterns in MR elastography of skeletal muscle using
	coupled harmonic oscillator simulations.},
  journal = {Magn Reson Imaging},
  year = {2002},
  volume = {20},
  pages = {95--104},
  number = {1},
  month = {Jan},
  abstract = {The ability to study muscle elasticity in vivo would be of great clinical
	interest. Magnetic resonance elastography (MRE) has the potential
	to quantify noninvasively the distribution of the shear modulus in
	muscle tissue. Elasticity information may be derived by extracting
	frequencies from the wave patterns of phase-contrast MRE images.
	In a new approach, MRE wave patterns were reconstructed using 3D
	coupled harmonic oscillator calculations (CHO). To analyze in vivo
	MRE measurements of the biceps brachii of healthy volunteers, different
	anisotropic fibrous structures for the couplings between the muscle
	elements have to be assumed. V-shaped wave patterns as observed when
	excitation was applied on the tendon were reproduced by a model,
	where in a central band of stiff fascicles wave propagation was about
	twice as fast as that in surrounding tissue. Planar waves were observed
	for excitation near the muscle surface. They could be reconstructed
	by assuming a simultaneous wave excitation of all muscle fibers,
	where fibers along the main muscle axis were coupled more strongly
	than those perpendicular to the axis. The results show that CHO calculations
	provide a fast and reliable method for incorporating anatomical information
	of the investigated tissue in the reconstruction of complex wave
	patterns.},
  institution = {any. i.sack@medizin.fu-berlin.de},
  keywords = {Acoustic Stimulation; Arm, physiology; Biomechanics; Elasticity; Humans;
	Image Processing, Computer-Assisted; Magnetic Resonance Imaging,
	methods; Models, Statistical; Muscle, Skeletal, physiology},
  language = {eng},
  medline-pst = {ppublish},
  owner = {Heiko},
  pii = {S0730725X02004745},
  pmid = {11973034},
  timestamp = {2013.07.26}
}
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