Nanoparticle Surface Functionality Dictates Cellular and Systemic Toxicity. Saei, A., Yazdani, M, Lohse, S., Bakhtiary, Z, Serpooshan, V, Ghavami, M, Asadian, M, Mashaghi, S, Dreaden, E., Mashaghi, A, & Mahmoudi, M Chemistry of Materials, 29(16):6578–6595, August, 2017. doi abstract bibtex © 2017 American Chemical Society. Engineered nanoparticles (NPs) have opened new frontiers in therapeutics and diagnostics in recent years. The surface functionality of these nanoparticles often predominates their interactions with various biological components of human body, and proper selection or control of surface functionality can greatly enhance subsequent therapeutic effects of NPs while diminishing their adverse side effects. In this review, we will focus on the effect of surface functionality on the cellular uptake and the transport of NPs by various subcellular processes.
@article{saei_nanoparticle_2017,
title = {Nanoparticle {Surface} {Functionality} {Dictates} {Cellular} and {Systemic} {Toxicity}},
volume = {29},
issn = {0897-4756},
doi = {10.1021/acs.chemmater.7b01979},
abstract = {© 2017 American Chemical Society. Engineered nanoparticles (NPs) have opened new frontiers in therapeutics and diagnostics in recent years. The surface functionality of these nanoparticles often predominates their interactions with various biological components of human body, and proper selection or control of surface functionality can greatly enhance subsequent therapeutic effects of NPs while diminishing their adverse side effects. In this review, we will focus on the effect of surface functionality on the cellular uptake and the transport of NPs by various subcellular processes.},
number = {16},
journal = {Chemistry of Materials},
author = {Saei, AA and Yazdani, M and Lohse, SE and Bakhtiary, Z and Serpooshan, V and Ghavami, M and Asadian, M and Mashaghi, S and Dreaden, EC and Mashaghi, A and Mahmoudi, M},
month = aug,
year = {2017},
pages = {6578--6595}
}
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