Origin and spread of human mitochondrial DNA haplogroup U7

Origin and spread of human mitochondrial DNA haplogroup U7. Sahakyan, H., Hooshiar Kashani, B., Tamang, R., Kushniarevich, A., Francis, A., Costa, M. D, Pathak, A. K., Khachatryan, Z., Sharma, I., Van Oven, M., Parik, J., Hovhannisyan, H., Metspalu, E., Pennarun, E., Karmin, M., Tamm, E., Tambets, K., Bahmanimehr, A., Reisberg, T., Reidla, M., Achilli, A., Olivieri, A., Gandini, F., Perego, U. A., Al-Zahery, N., Houshmand, M., Sanati, M. H., Soares, P., Rai, E., Šarac, J., Šarić, T., Sharma, V., Pereira, L., Fernandes, V., Černý, V., Farjadian, S., Singh, D. P., Azakli, H., Üstek, D., Ekomasova, N., Kutuev, I., Litvinov, S., Bermisheva, M., Khusnutdinova, E. K., Rai, N., Singh, M., Singh, V. K., Reddy, A. G., Tolk, H., Cvjetan, S., Lauc, L. B., Rudan, P., Michalodimitrakis, E. N., Anagnou, N. P., Pappa, K. I., Golubenko, M. V., Orekhov, V., Borinskaya, S. A, Kaldma, K., Schauer, M. A., Simionescu, M., Gusar, V., Grechanina, E., Govindaraj, P., Voevoda, M., Damba, L., Sharma, S., Singh, L., Semino, O., Behar, D. M., Yepiskoposyan, L., Richards, M. B., Metspalu, M., Kivisild, T., Thangaraj, K., Endicott, P., Chaubey, G., Torroni, A., & Villems, R. Scientific Reports, 7(1):46044, April, 2017.

Paper doi abstract bibtex

Abstract Human mitochondrial DNA haplogroup U is among the initial maternal founders in Southwest Asia and Europe and one that best indicates matrilineal genetic continuity between late Pleistocene hunter-gatherer groups and present-day populations of Europe. While most haplogroup U subclades are older than 30 thousand years, the comparatively recent coalescence time of the extant variation of haplogroup U7 (~16–19 thousand years ago) suggests that its current distribution is the consequence of more recent dispersal events, despite its wide geographical range across Europe, the Near East and South Asia. Here we report 267 new U7 mitogenomes that – analysed alongside 100 published ones – enable us to discern at least two distinct temporal phases of dispersal, both of which most likely emanated from the Near East. The earlier one began prior to the Holocene (~11.5 thousand years ago) towards South Asia, while the later dispersal took place more recently towards Mediterranean Europe during the Neolithic (~8 thousand years ago). These findings imply that the carriers of haplogroup U7 spread to South Asia and Europe before the suggested Bronze Age expansion of Indo-European languages from the Pontic-Caspian Steppe region.

@article{sahakyan_origin_2017,
	title = {Origin and spread of human mitochondrial {DNA} haplogroup {U7}},
	volume = {7},
	issn = {2045-2322},
	url = {https://www.nature.com/articles/srep46044},
	doi = {10.1038/srep46044},
	abstract = {Abstract
            Human mitochondrial DNA haplogroup U is among the initial maternal founders in Southwest Asia and Europe and one that best indicates matrilineal genetic continuity between late Pleistocene hunter-gatherer groups and present-day populations of Europe. While most haplogroup U subclades are older than 30 thousand years, the comparatively recent coalescence time of the extant variation of haplogroup U7 ({\textasciitilde}16–19 thousand years ago) suggests that its current distribution is the consequence of more recent dispersal events, despite its wide geographical range across Europe, the Near East and South Asia. Here we report 267 new U7 mitogenomes that – analysed alongside 100 published ones – enable us to discern at least two distinct temporal phases of dispersal, both of which most likely emanated from the Near East. The earlier one began prior to the Holocene ({\textasciitilde}11.5 thousand years ago) towards South Asia, while the later dispersal took place more recently towards Mediterranean Europe during the Neolithic ({\textasciitilde}8 thousand years ago). These findings imply that the carriers of haplogroup U7 spread to South Asia and Europe before the suggested Bronze Age expansion of Indo-European languages from the Pontic-Caspian Steppe region.},
	language = {en},
	number = {1},
	urldate = {2024-01-21},
	journal = {Scientific Reports},
	author = {Sahakyan, Hovhannes and Hooshiar Kashani, Baharak and Tamang, Rakesh and Kushniarevich, Alena and Francis, Amirtharaj and Costa, Marta D and Pathak, Ajai Kumar and Khachatryan, Zaruhi and Sharma, Indu and Van Oven, Mannis and Parik, Jüri and Hovhannisyan, Hrant and Metspalu, Ene and Pennarun, Erwan and Karmin, Monika and Tamm, Erika and Tambets, Kristiina and Bahmanimehr, Ardeshir and Reisberg, Tuuli and Reidla, Maere and Achilli, Alessandro and Olivieri, Anna and Gandini, Francesca and Perego, Ugo A. and Al-Zahery, Nadia and Houshmand, Massoud and Sanati, Mohammad Hossein and Soares, Pedro and Rai, Ekta and Šarac, Jelena and Šarić, Tena and Sharma, Varun and Pereira, Luisa and Fernandes, Veronica and Černý, Viktor and Farjadian, Shirin and Singh, Deepankar Pratap and Azakli, Hülya and Üstek, Duran and Ekomasova, Natalia and Kutuev, Ildus and Litvinov, Sergei and Bermisheva, Marina and Khusnutdinova, Elza K. and Rai, Niraj and Singh, Manvendra and Singh, Vijay Kumar and Reddy, Alla G. and Tolk, Helle-Viivi and Cvjetan, Svjetlana and Lauc, Lovorka Barac and Rudan, Pavao and Michalodimitrakis, Emmanuel N. and Anagnou, Nicholas P. and Pappa, Kalliopi I. and Golubenko, Maria V. and Orekhov, Vladimir and Borinskaya, Svetlana A and Kaldma, Katrin and Schauer, Monica A. and Simionescu, Maya and Gusar, Vladislava and Grechanina, Elena and Govindaraj, Periyasamy and Voevoda, Mikhail and Damba, Larissa and Sharma, Swarkar and Singh, Lalji and Semino, Ornella and Behar, Doron M. and Yepiskoposyan, Levon and Richards, Martin B. and Metspalu, Mait and Kivisild, Toomas and Thangaraj, Kumarasamy and Endicott, Phillip and Chaubey, Gyaneshwer and Torroni, Antonio and Villems, Richard},
	month = apr,
	year = {2017},
	pages = {46044},
}

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