Smoking history and Alzheimer's disease risk in a community-based clinic population. Saito, E. K., Diaz, N., Chung, J., & McMurtray, A. Journal of Education and Health Promotion, 6:24, 2017. doi abstract bibtex BACKGROUND: The relationship between cigarette smoking and development of Alzheimer's disease (AD) is not fully determined, and previous reports disagree, with some studies suggesting an increased relative risk and others a decreased odds ratio. Consequently, we wanted to determine if the prevalence of past cigarette smoking observed in a community-based clinic sample of patients with AD would be more consistent with the expected value obtained from a model using either an increased relative risk or a decreased odds ratio to estimate the effect of smoking on development of AD. MATERIALS AND METHODS: Retrospective cross-sectional analysis of all patients treated for AD in a community-based Neurology Clinic during a 2-year period. Estimates of expected past smoking prevalence were calculated based on published values for either an increased relative risk or a decreased odds ratio and compared to the past smoking prevalence observed in the clinic sample. RESULTS: The observed past smoking prevalence in the clinic population was 29.17%. The expected past smoking prevalence calculated using the increased relative risk was 30.07% (95% confidence interval [CI] = 27.67-32.32%), and using the decreased odds ratio was 12.54% (95% CI = 6.32-24.81%). CONCLUSION: The observed past smoking prevalence among the patients being treated for AD in a community-based clinic falls within the expected 95% CI for the increased relative risk model and outside of the expected 95% CI for the decreased odds ratio model. These results support the contention that the relationship between cigarette smoking and development of AD is the best characterized by an increased relative risk.
@article{saito_smoking_2017,
title = {Smoking history and {Alzheimer}'s disease risk in a community-based clinic population},
volume = {6},
issn = {2277-9531},
doi = {10.4103/jehp.jehp_45_15},
abstract = {BACKGROUND: The relationship between cigarette smoking and development of Alzheimer's disease (AD) is not fully determined, and previous reports disagree, with some studies suggesting an increased relative risk and others a decreased odds ratio. Consequently, we wanted to determine if the prevalence of past cigarette smoking observed in a community-based clinic sample of patients with AD would be more consistent with the expected value obtained from a model using either an increased relative risk or a decreased odds ratio to estimate the effect of smoking on development of AD.
MATERIALS AND METHODS: Retrospective cross-sectional analysis of all patients treated for AD in a community-based Neurology Clinic during a 2-year period. Estimates of expected past smoking prevalence were calculated based on published values for either an increased relative risk or a decreased odds ratio and compared to the past smoking prevalence observed in the clinic sample.
RESULTS: The observed past smoking prevalence in the clinic population was 29.17\%. The expected past smoking prevalence calculated using the increased relative risk was 30.07\% (95\% confidence interval [CI] = 27.67-32.32\%), and using the decreased odds ratio was 12.54\% (95\% CI = 6.32-24.81\%).
CONCLUSION: The observed past smoking prevalence among the patients being treated for AD in a community-based clinic falls within the expected 95\% CI for the increased relative risk model and outside of the expected 95\% CI for the decreased odds ratio model. These results support the contention that the relationship between cigarette smoking and development of AD is the best characterized by an increased relative risk.},
language = {eng},
journal = {Journal of Education and Health Promotion},
author = {Saito, Erin K. and Diaz, Natalie and Chung, Julia and McMurtray, Aaron},
year = {2017},
pmid = {28584824},
pmcid = {PMC5441192},
keywords = {8 Ignorance and funding bias, Alzheimer's disease, Biais de financement, PRINTED (Fonds papier), dementia, epidemiology, smoking},
pages = {24},
}
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Consequently, we wanted to determine if the prevalence of past cigarette smoking observed in a community-based clinic sample of patients with AD would be more consistent with the expected value obtained from a model using either an increased relative risk or a decreased odds ratio to estimate the effect of smoking on development of AD. MATERIALS AND METHODS: Retrospective cross-sectional analysis of all patients treated for AD in a community-based Neurology Clinic during a 2-year period. Estimates of expected past smoking prevalence were calculated based on published values for either an increased relative risk or a decreased odds ratio and compared to the past smoking prevalence observed in the clinic sample. RESULTS: The observed past smoking prevalence in the clinic population was 29.17%. The expected past smoking prevalence calculated using the increased relative risk was 30.07% (95% confidence interval [CI] = 27.67-32.32%), and using the decreased odds ratio was 12.54% (95% CI = 6.32-24.81%). CONCLUSION: The observed past smoking prevalence among the patients being treated for AD in a community-based clinic falls within the expected 95% CI for the increased relative risk model and outside of the expected 95% CI for the decreased odds ratio model. These results support the contention that the relationship between cigarette smoking and development of AD is the best characterized by an increased relative risk.","language":"eng","journal":"Journal of Education and Health Promotion","author":[{"propositions":[],"lastnames":["Saito"],"firstnames":["Erin","K."],"suffixes":[]},{"propositions":[],"lastnames":["Diaz"],"firstnames":["Natalie"],"suffixes":[]},{"propositions":[],"lastnames":["Chung"],"firstnames":["Julia"],"suffixes":[]},{"propositions":[],"lastnames":["McMurtray"],"firstnames":["Aaron"],"suffixes":[]}],"year":"2017","pmid":"28584824","pmcid":"PMC5441192","keywords":"8 Ignorance and funding bias, Alzheimer's disease, Biais de financement, PRINTED (Fonds papier), dementia, epidemiology, smoking","pages":"24","bibtex":"@article{saito_smoking_2017,\n\ttitle = {Smoking history and {Alzheimer}'s disease risk in a community-based clinic population},\n\tvolume = {6},\n\tissn = {2277-9531},\n\tdoi = {10.4103/jehp.jehp_45_15},\n\tabstract = {BACKGROUND: The relationship between cigarette smoking and development of Alzheimer's disease (AD) is not fully determined, and previous reports disagree, with some studies suggesting an increased relative risk and others a decreased odds ratio. Consequently, we wanted to determine if the prevalence of past cigarette smoking observed in a community-based clinic sample of patients with AD would be more consistent with the expected value obtained from a model using either an increased relative risk or a decreased odds ratio to estimate the effect of smoking on development of AD.\nMATERIALS AND METHODS: Retrospective cross-sectional analysis of all patients treated for AD in a community-based Neurology Clinic during a 2-year period. Estimates of expected past smoking prevalence were calculated based on published values for either an increased relative risk or a decreased odds ratio and compared to the past smoking prevalence observed in the clinic sample.\nRESULTS: The observed past smoking prevalence in the clinic population was 29.17\\%. The expected past smoking prevalence calculated using the increased relative risk was 30.07\\% (95\\% confidence interval [CI] = 27.67-32.32\\%), and using the decreased odds ratio was 12.54\\% (95\\% CI = 6.32-24.81\\%).\nCONCLUSION: The observed past smoking prevalence among the patients being treated for AD in a community-based clinic falls within the expected 95\\% CI for the increased relative risk model and outside of the expected 95\\% CI for the decreased odds ratio model. These results support the contention that the relationship between cigarette smoking and development of AD is the best characterized by an increased relative risk.},\n\tlanguage = {eng},\n\tjournal = {Journal of Education and Health Promotion},\n\tauthor = {Saito, Erin K. and Diaz, Natalie and Chung, Julia and McMurtray, Aaron},\n\tyear = {2017},\n\tpmid = {28584824},\n\tpmcid = {PMC5441192},\n\tkeywords = {8 Ignorance and funding bias, Alzheimer's disease, Biais de financement, PRINTED (Fonds papier), dementia, epidemiology, smoking},\n\tpages = {24},\n}\n\n","author_short":["Saito, E. 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