@article{RN85,
   author = {Salameh, Z. S. and Aycock, K. N. and Alinezhadbalalami, N. and Imran, K. M. and McKillop, I. H. and Allen, I. C. and Davalos, R. V.},
   title = {Harnessing the Electrochemical Effects of Electroporation-Based Therapies to Enhance Anti-tumor Immune Responses},
   journal = {Ann Biomed Eng},
   volume = {52},
   number = {1},
   pages = {48-56},
   note = {1573-9686
Salameh, Zaid S
Aycock, Kenneth N
Alinezhadbalalami, Nastaran
Imran, Khan Mohammad
McKillop, Iain H
Allen, Irving C
Davalos, Rafael V
Orcid: 0000-0003-1503-9509
R01 CA274439/CA/NCI NIH HHS/United States
R01 CA240476/CA/NCI NIH HHS/United States
Journal Article
United States
2023/11/22
Ann Biomed Eng. 2024 Jan;52(1):48-56. doi: 10.1007/s10439-023-03403-x. Epub 2023 Nov 21.},
   abstract = {This study introduces a new method of targeting acidosis (low pH) within the tumor microenvironment (TME) through the use of cathodic electrochemical reactions (CER). Low pH is oncogenic by supporting immunosuppression. Electrochemical reactions create local pH effects when a current passes through an electrolytic substrate such as biological tissue. Electrolysis has been used with electroporation (destabilization of the lipid bilayer via an applied electric potential) to increase cell death areas. However, the regulated increase of pH through only the cathode electrode has been ignored as a possible method to alleviate TME acidosis, which could provide substantial immunotherapeutic benefits. Here, we show through ex vivo modeling that CERs can intentionally elevate pH to an anti-tumor level and that increased alkalinity promotes activation of naïve macrophages. This study shows the potential of CERs to improve acidity within the TME and that it has the potential to be paired with existing electric field-based cancer therapies or as a stand-alone therapy.},
   keywords = {Humans
*Neoplasms/therapy
Electroporation/methods
Electricity
Immunity
*Acidosis
Tumor Microenvironment
Ablation
Anti-tumor
Direct current
Electrochemical
Electroporation
Hepatocellular carcinoma
Immunology
Immunosuppressive
Irreversible electroporation
Thp-1
Tumor-associated macrophages
Warburg effect
pH},
   ISSN = {0090-6964 (Print)
0090-6964},
   DOI = {10.1007/s10439-023-03403-x},
   year = {2024},
   type = {Journal Article}
}

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V."],"bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Salameh"],"firstnames":["Z.","S."],"suffixes":[]},{"propositions":[],"lastnames":["Aycock"],"firstnames":["K.","N."],"suffixes":[]},{"propositions":[],"lastnames":["Alinezhadbalalami"],"firstnames":["N."],"suffixes":[]},{"propositions":[],"lastnames":["Imran"],"firstnames":["K.","M."],"suffixes":[]},{"propositions":[],"lastnames":["McKillop"],"firstnames":["I.","H."],"suffixes":[]},{"propositions":[],"lastnames":["Allen"],"firstnames":["I.","C."],"suffixes":[]},{"propositions":[],"lastnames":["Davalos"],"firstnames":["R.","V."],"suffixes":[]}],"title":"Harnessing the Electrochemical Effects of Electroporation-Based Therapies to Enhance Anti-tumor Immune Responses","journal":"Ann Biomed Eng","volume":"52","number":"1","pages":"48-56","note":"1573-9686 Salameh, Zaid S Aycock, Kenneth N Alinezhadbalalami, Nastaran Imran, Khan Mohammad McKillop, Iain H Allen, Irving C Davalos, Rafael V Orcid: 0000-0003-1503-9509 R01 CA274439/CA/NCI NIH HHS/United States R01 CA240476/CA/NCI NIH HHS/United States Journal Article United States 2023/11/22 Ann Biomed Eng. 2024 Jan;52(1):48-56. doi: 10.1007/s10439-023-03403-x. Epub 2023 Nov 21.","abstract":"This study introduces a new method of targeting acidosis (low pH) within the tumor microenvironment (TME) through the use of cathodic electrochemical reactions (CER). Low pH is oncogenic by supporting immunosuppression. Electrochemical reactions create local pH effects when a current passes through an electrolytic substrate such as biological tissue. Electrolysis has been used with electroporation (destabilization of the lipid bilayer via an applied electric potential) to increase cell death areas. However, the regulated increase of pH through only the cathode electrode has been ignored as a possible method to alleviate TME acidosis, which could provide substantial immunotherapeutic benefits. Here, we show through ex vivo modeling that CERs can intentionally elevate pH to an anti-tumor level and that increased alkalinity promotes activation of naïve macrophages. This study shows the potential of CERs to improve acidity within the TME and that it has the potential to be paired with existing electric field-based cancer therapies or as a stand-alone therapy.","keywords":"Humans *Neoplasms/therapy Electroporation/methods Electricity Immunity *Acidosis Tumor Microenvironment Ablation Anti-tumor Direct current Electrochemical Electroporation Hepatocellular carcinoma Immunology Immunosuppressive Irreversible electroporation Thp-1 Tumor-associated macrophages Warburg effect pH","issn":"0090-6964 (Print) 0090-6964","doi":"10.1007/s10439-023-03403-x","year":"2024","bibtex":"@article{RN85,\n author = {Salameh, Z. S. and Aycock, K. N. and Alinezhadbalalami, N. and Imran, K. M. and McKillop, I. H. and Allen, I. C. and Davalos, R. V.},\n title = {Harnessing the Electrochemical Effects of Electroporation-Based Therapies to Enhance Anti-tumor Immune Responses},\n journal = {Ann Biomed Eng},\n volume = {52},\n number = {1},\n pages = {48-56},\n note = {1573-9686\nSalameh, Zaid S\nAycock, Kenneth N\nAlinezhadbalalami, Nastaran\nImran, Khan Mohammad\nMcKillop, Iain H\nAllen, Irving C\nDavalos, Rafael V\nOrcid: 0000-0003-1503-9509\nR01 CA274439/CA/NCI NIH HHS/United States\nR01 CA240476/CA/NCI NIH HHS/United States\nJournal Article\nUnited States\n2023/11/22\nAnn Biomed Eng. 2024 Jan;52(1):48-56. doi: 10.1007/s10439-023-03403-x. Epub 2023 Nov 21.},\n abstract = {This study introduces a new method of targeting acidosis (low pH) within the tumor microenvironment (TME) through the use of cathodic electrochemical reactions (CER). Low pH is oncogenic by supporting immunosuppression. Electrochemical reactions create local pH effects when a current passes through an electrolytic substrate such as biological tissue. Electrolysis has been used with electroporation (destabilization of the lipid bilayer via an applied electric potential) to increase cell death areas. However, the regulated increase of pH through only the cathode electrode has been ignored as a possible method to alleviate TME acidosis, which could provide substantial immunotherapeutic benefits. Here, we show through ex vivo modeling that CERs can intentionally elevate pH to an anti-tumor level and that increased alkalinity promotes activation of naïve macrophages. This study shows the potential of CERs to improve acidity within the TME and that it has the potential to be paired with existing electric field-based cancer therapies or as a stand-alone therapy.},\n keywords = {Humans\n*Neoplasms/therapy\nElectroporation/methods\nElectricity\nImmunity\n*Acidosis\nTumor Microenvironment\nAblation\nAnti-tumor\nDirect current\nElectrochemical\nElectroporation\nHepatocellular carcinoma\nImmunology\nImmunosuppressive\nIrreversible electroporation\nThp-1\nTumor-associated macrophages\nWarburg effect\npH},\n ISSN = {0090-6964 (Print)\n0090-6964},\n DOI = {10.1007/s10439-023-03403-x},\n year = {2024},\n type = {Journal Article}\n}\n\n","author_short":["Salameh, Z. S.","Aycock, K. N.","Alinezhadbalalami, N.","Imran, K. M.","McKillop, I. H.","Allen, I. C.","Davalos, R. V."],"key":"RN85","id":"RN85","bibbaseid":"salameh-aycock-alinezhadbalalami-imran-mckillop-allen-davalos-harnessingtheelectrochemicaleffectsofelectroporationbasedtherapiestoenhanceantitumorimmuneresponses-2024","role":"author","urls":{},"keyword":["Humans *Neoplasms/therapy Electroporation/methods Electricity Immunity *Acidosis Tumor Microenvironment Ablation Anti-tumor Direct current Electrochemical Electroporation Hepatocellular carcinoma Immunology Immunosuppressive Irreversible electroporation Thp-1 Tumor-associated macrophages Warburg effect pH"],"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://bibbase.org/network/files/bdNBTZRXTsoHCgpbh","dataSources":["D4zENc4BfFNBwSYYJ","ZPLjameRikygaiM9B","3XfNmZkLe6o8CvECW","fJQsxtBoqymHQG6tL","LzxgEApraxMPkLTMn","Z2THpXfLYEJf3CB8p"],"keywords":["humans *neoplasms/therapy electroporation/methods electricity immunity *acidosis tumor microenvironment ablation anti-tumor direct current electrochemical electroporation hepatocellular carcinoma immunology immunosuppressive irreversible electroporation thp-1 tumor-associated macrophages warburg effect ph"],"search_terms":["harnessing","electrochemical","effects","electroporation","based","therapies","enhance","anti","tumor","immune","responses","salameh","aycock","alinezhadbalalami","imran","mckillop","allen","davalos"],"title":"Harnessing the Electrochemical Effects of Electroporation-Based Therapies to Enhance Anti-tumor Immune Responses","year":2024}