Premature commitment to uncertain decisions during human NMDA receptor hypofunction. Salvador, A., Arnal, L. H., Vinckier, F., Domenech, P., Gaillard, R., & Wyart, V. Nature Communications, 13(1):338, Nature Publishing Group, January, 2022. Number: 1![Premature commitment to uncertain decisions during human NMDA receptor hypofunction [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Making accurate decisions based on unreliable sensory evidence requires cognitive inference. Dysfunction of n-methyl-d-aspartate (NMDA) receptors impairs the integration of noisy input in theoretical models of neural circuits, but whether and how this synaptic alteration impairs human inference and confidence during uncertain decisions remains unknown. Here we use placebo-controlled infusions of ketamine to characterize the causal effect of human NMDA receptor hypofunction on cognitive inference and its neural correlates. At the behavioral level, ketamine triggers inference errors and elevated decision uncertainty. At the neural level, ketamine is associated with imbalanced coding of evidence and premature response preparation in electroencephalographic (EEG) activity. Through computational modeling of inference and confidence, we propose that this specific pattern of behavioral and neural impairments reflects an early commitment to inaccurate decisions, which aims at resolving the abnormal uncertainty generated by NMDA receptor hypofunction.
@article{salvador_premature_2022,
title = {Premature commitment to uncertain decisions during human {NMDA} receptor hypofunction},
volume = {13},
copyright = {2022 The Author(s)},
issn = {2041-1723},
url = {https://www.nature.com/articles/s41467-021-27876-3},
doi = {10.1038/s41467-021-27876-3},
abstract = {Making accurate decisions based on unreliable sensory evidence requires cognitive inference. Dysfunction of n-methyl-d-aspartate (NMDA) receptors impairs the integration of noisy input in theoretical models of neural circuits, but whether and how this synaptic alteration impairs human inference and confidence during uncertain decisions remains unknown. Here we use placebo-controlled infusions of ketamine to characterize the causal effect of human NMDA receptor hypofunction on cognitive inference and its neural correlates. At the behavioral level, ketamine triggers inference errors and elevated decision uncertainty. At the neural level, ketamine is associated with imbalanced coding of evidence and premature response preparation in electroencephalographic (EEG) activity. Through computational modeling of inference and confidence, we propose that this specific pattern of behavioral and neural impairments reflects an early commitment to inaccurate decisions, which aims at resolving the abnormal uncertainty generated by NMDA receptor hypofunction.},
language = {en},
number = {1},
urldate = {2022-02-04},
journal = {Nature Communications},
publisher = {Nature Publishing Group},
author = {Salvador, Alexandre and Arnal, Luc H. and Vinckier, Fabien and Domenech, Philippe and Gaillard, Raphaël and Wyart, Valentin},
month = jan,
year = {2022},
note = {Number: 1},
keywords = {Decision, Human behaviour},
pages = {338},
}
Downloads: 0
{"_id":"LyARpP8Zsy3E32oDR","bibbaseid":"salvador-arnal-vinckier-domenech-gaillard-wyart-prematurecommitmenttouncertaindecisionsduringhumannmdareceptorhypofunction-2022","author_short":["Salvador, A.","Arnal, L. H.","Vinckier, F.","Domenech, P.","Gaillard, R.","Wyart, V."],"bibdata":{"bibtype":"article","type":"article","title":"Premature commitment to uncertain decisions during human NMDA receptor hypofunction","volume":"13","copyright":"2022 The Author(s)","issn":"2041-1723","url":"https://www.nature.com/articles/s41467-021-27876-3","doi":"10.1038/s41467-021-27876-3","abstract":"Making accurate decisions based on unreliable sensory evidence requires cognitive inference. Dysfunction of n-methyl-d-aspartate (NMDA) receptors impairs the integration of noisy input in theoretical models of neural circuits, but whether and how this synaptic alteration impairs human inference and confidence during uncertain decisions remains unknown. Here we use placebo-controlled infusions of ketamine to characterize the causal effect of human NMDA receptor hypofunction on cognitive inference and its neural correlates. At the behavioral level, ketamine triggers inference errors and elevated decision uncertainty. At the neural level, ketamine is associated with imbalanced coding of evidence and premature response preparation in electroencephalographic (EEG) activity. Through computational modeling of inference and confidence, we propose that this specific pattern of behavioral and neural impairments reflects an early commitment to inaccurate decisions, which aims at resolving the abnormal uncertainty generated by NMDA receptor hypofunction.","language":"en","number":"1","urldate":"2022-02-04","journal":"Nature Communications","publisher":"Nature Publishing Group","author":[{"propositions":[],"lastnames":["Salvador"],"firstnames":["Alexandre"],"suffixes":[]},{"propositions":[],"lastnames":["Arnal"],"firstnames":["Luc","H."],"suffixes":[]},{"propositions":[],"lastnames":["Vinckier"],"firstnames":["Fabien"],"suffixes":[]},{"propositions":[],"lastnames":["Domenech"],"firstnames":["Philippe"],"suffixes":[]},{"propositions":[],"lastnames":["Gaillard"],"firstnames":["Raphaël"],"suffixes":[]},{"propositions":[],"lastnames":["Wyart"],"firstnames":["Valentin"],"suffixes":[]}],"month":"January","year":"2022","note":"Number: 1","keywords":"Decision, Human behaviour","pages":"338","bibtex":"@article{salvador_premature_2022,\n\ttitle = {Premature commitment to uncertain decisions during human {NMDA} receptor hypofunction},\n\tvolume = {13},\n\tcopyright = {2022 The Author(s)},\n\tissn = {2041-1723},\n\turl = {https://www.nature.com/articles/s41467-021-27876-3},\n\tdoi = {10.1038/s41467-021-27876-3},\n\tabstract = {Making accurate decisions based on unreliable sensory evidence requires cognitive inference. Dysfunction of n-methyl-d-aspartate (NMDA) receptors impairs the integration of noisy input in theoretical models of neural circuits, but whether and how this synaptic alteration impairs human inference and confidence during uncertain decisions remains unknown. Here we use placebo-controlled infusions of ketamine to characterize the causal effect of human NMDA receptor hypofunction on cognitive inference and its neural correlates. At the behavioral level, ketamine triggers inference errors and elevated decision uncertainty. At the neural level, ketamine is associated with imbalanced coding of evidence and premature response preparation in electroencephalographic (EEG) activity. Through computational modeling of inference and confidence, we propose that this specific pattern of behavioral and neural impairments reflects an early commitment to inaccurate decisions, which aims at resolving the abnormal uncertainty generated by NMDA receptor hypofunction.},\n\tlanguage = {en},\n\tnumber = {1},\n\turldate = {2022-02-04},\n\tjournal = {Nature Communications},\n\tpublisher = {Nature Publishing Group},\n\tauthor = {Salvador, Alexandre and Arnal, Luc H. and Vinckier, Fabien and Domenech, Philippe and Gaillard, Raphaël and Wyart, Valentin},\n\tmonth = jan,\n\tyear = {2022},\n\tnote = {Number: 1},\n\tkeywords = {Decision, Human behaviour},\n\tpages = {338},\n}\n\n\n\n\n\n\n\n\n\n\n\n","author_short":["Salvador, A.","Arnal, L. H.","Vinckier, F.","Domenech, P.","Gaillard, R.","Wyart, V."],"key":"salvador_premature_2022","id":"salvador_premature_2022","bibbaseid":"salvador-arnal-vinckier-domenech-gaillard-wyart-prematurecommitmenttouncertaindecisionsduringhumannmdareceptorhypofunction-2022","role":"author","urls":{"Paper":"https://www.nature.com/articles/s41467-021-27876-3"},"keyword":["Decision","Human behaviour"],"metadata":{"authorlinks":{}},"downloads":0,"html":""},"bibtype":"article","biburl":"https://bibbase.org/zotero/warren.pettine","dataSources":["zYjFbyFmZWKpRCD4j"],"keywords":["decision","human behaviour"],"search_terms":["premature","commitment","uncertain","decisions","during","human","nmda","receptor","hypofunction","salvador","arnal","vinckier","domenech","gaillard","wyart"],"title":"Premature commitment to uncertain decisions during human NMDA receptor hypofunction","year":2022}