Cognitive dysfunction in major depression and Alzheimer's disease is associated with hippocampal-prefrontal cortex dysconnectivity. Sampath, D., Sathyanesan, M., & Newton, S. S Neuropsychiatr. Dis. Treat., 13:1509--1519, June, 2017. 00000
Cognitive dysfunction in major depression and Alzheimer's disease is associated with hippocampal-prefrontal cortex dysconnectivity [link]Paper  doi  abstract   bibtex   
Cognitive dysfunction is prevalent in psychiatric disorders. Deficits are observed in multiple domains, including working memory, executive function, attention, and information processing. Disability caused by cognitive dysfunction is frequently as debilitating as the prominent emotional disturbances. Interactions between the hippocampus and the prefrontal cortex are increasingly appreciated as an important link between cognition and emotion. Recent developments in optogenetics, imaging, and connectomics can enable the investigation of this circuit in a manner that is relevant to disease pathophysiology. The goal of this review is to shed light on the contributions of this circuit to cognitive dysfunction in neuropsychiatric disorders, focusing on Alzheimer's disease and depression.
@article{sampath_cognitive_2017,
	title = {Cognitive dysfunction in major depression and {Alzheimer}'s disease is associated with hippocampal-prefrontal cortex dysconnectivity},
	volume = {13},
	issn = {1176-6328},
	url = {http://dx.doi.org/10.2147/NDT.S136122},
	doi = {10.2147/NDT.S136122},
	abstract = {Cognitive dysfunction is prevalent in psychiatric disorders. Deficits are
observed in multiple domains, including working memory, executive
function, attention, and information processing. Disability caused by
cognitive dysfunction is frequently as debilitating as the prominent
emotional disturbances. Interactions between the hippocampus and the
prefrontal cortex are increasingly appreciated as an important link
between cognition and emotion. Recent developments in optogenetics,
imaging, and connectomics can enable the investigation of this circuit in
a manner that is relevant to disease pathophysiology. The goal of this
review is to shed light on the contributions of this circuit to cognitive
dysfunction in neuropsychiatric disorders, focusing on Alzheimer's disease
and depression.},
	journal = {Neuropsychiatr. Dis. Treat.},
	author = {Sampath, Dayalan and Sathyanesan, Monica and Newton, Samuel S},
	month = jun,
	year = {2017},
	note = {00000},
	keywords = {Alzheimer’s disease, Sep 20 import, cognition, depression, duplicate, hippocampus, prefrontal cortex},
	pages = {1509--1519}
}

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