The Mediterranean Diet Protects the Renal Function in Older Adults: A Prospective Cohort Study. Sandoval-Insausti, H., Bayan-Bravo, A., Donat-Vargas, C., Rey-Garcia, J., Banegas, J. R., Rodriguez-Artalejo, F., & Guallar-Castillon Q2818013A, P. Current Developments in Nutrition, 4(Supplement_2):562–562, June, 2020.
The Mediterranean Diet Protects the Renal Function in Older Adults: A Prospective Cohort Study [link]Paper  doi  abstract   bibtex   4 downloads  
Abstract Objectives It is not clear if the adherence to a Mediterranean diet is associated with changes in kidney function. The aim of this study is to assess the prospective association between the adherence to the Mediterranean diet and renal function decline. Methods Prospective cohort study of 975 community-dwelling individuals aged 60 and older who were recruited during 2008–10 in Spain, and followed up to December, 2015. At baseline, food consumption was obtained with a validated, computerized face-to-face diet history. The “a priori” adherence to the Mediterranean diet was assessed with the Mediterranean Diet Adherence Screener (MEDAS score: low adherence 0–5 points, moderate adherence 6–8 points, high adherence 9–14 points). To identify “a posteriori” dietary patterns, 880 foods were categorized into 36 different groups according to similarities in their nutritional profile. Factor analysis (principal components analysis) was applied to generate independent dietary patterns. At baseline and at the end of follow-up, serum creatinine (SC) and glomerular filtration rate (GFR) levels were ascertained and changes were calculated. Two end-points were considered: SC increase and GFR decrease beyond that expected for age. Logistic regression models were built and adjusted for prevalent and incident cardiovascular risk factors. Results At the end of follow-up 150 cases of SC increase and 146 cases of GFR decrease occurred. The fully adjusted ORs (95% CI) of SC increase were 0.75 (0.49–1.15) for participants with a moderate adherence to the MEDAS score, and 0.58 (0.36–0.95) for those with a high adherence, when comparing to participants with a low adherence; (p-trend: 0.026). Results for GFR decrease had the same direction (p-trend: 0.049). The fully adjusted ORs (95% CI) of SC increase according to increasing quartiles of adherence to an “a posteriori” Mediterranean-like dietary pattern were 1.00, 0.62 (0.37–1.03), 0.57 (0.33–0.99), and 0.46 (0.24–0.86); (p-trend: 0.017). Results for GFR decrease were similar (p-trend: 0.007). Conclusions A higher adherence to a Mediterranean dietary pattern was associated with a lower risk of kidney function decline. Funding Sources State Secretary of R + D and FEDER/FSE, the ATHLOS project (EU H2020), and the CIBERESP, Instituto de Salud Carlos III. Madrid, Spain.
@article{sandoval-insausti_mediterranean_2020,
	title = {The {Mediterranean} {Diet} {Protects} the {Renal} {Function} in {Older} {Adults}: {A} {Prospective} {Cohort} {Study}},
	volume = {4},
	issn = {2475-2991},
	shorttitle = {The {Mediterranean} {Diet} {Protects} the {Renal} {Function} in {Older} {Adults}},
	url = {https://academic.oup.com/cdn/article/4/Supplement_2/562/5844193},
	doi = {10.1093/cdn/nzaa046_062},
	abstract = {Abstract
            
              Objectives
              It is not clear if the adherence to a Mediterranean diet is associated with changes in kidney function. The aim of this study is to assess the prospective association between the adherence to the Mediterranean diet and renal function decline.
            
            
              Methods
              Prospective cohort study of 975 community-dwelling individuals aged 60 and older who were recruited during 2008–10 in Spain, and followed up to December, 2015. At baseline, food consumption was obtained with a validated, computerized face-to-face diet history. The “a priori” adherence to the Mediterranean diet was assessed with the Mediterranean Diet Adherence Screener (MEDAS score: low adherence 0–5 points, moderate adherence 6–8 points, high adherence 9–14 points). To identify “a posteriori” dietary patterns, 880 foods were categorized into 36 different groups according to similarities in their nutritional profile. Factor analysis (principal components analysis) was applied to generate independent dietary patterns. At baseline and at the end of follow-up, serum creatinine (SC) and glomerular filtration rate (GFR) levels were ascertained and changes were calculated. Two end-points were considered: SC increase and GFR decrease beyond that expected for age. Logistic regression models were built and adjusted for prevalent and incident cardiovascular risk factors.
            
            
              Results
              At the end of follow-up 150 cases of SC increase and 146 cases of GFR decrease occurred. The fully adjusted ORs (95\% CI) of SC increase were 0.75 (0.49–1.15) for participants with a moderate adherence to the MEDAS score, and 0.58 (0.36–0.95) for those with a high adherence, when comparing to participants with a low adherence; (p-trend: 0.026). Results for GFR decrease had the same direction (p-trend: 0.049). The fully adjusted ORs (95\% CI) of SC increase according to increasing quartiles of adherence to an “a posteriori” Mediterranean-like dietary pattern were 1.00, 0.62 (0.37–1.03), 0.57 (0.33–0.99), and 0.46 (0.24–0.86); (p-trend: 0.017). Results for GFR decrease were similar (p-trend: 0.007).
            
            
              Conclusions
              A higher adherence to a Mediterranean dietary pattern was associated with a lower risk of kidney function decline.
            
            
              Funding Sources
              State Secretary of R + D and FEDER/FSE, the ATHLOS project (EU H2020), and the CIBERESP, Instituto de Salud Carlos III. Madrid, Spain.},
	language = {en},
	number = {Supplement\_2},
	urldate = {2022-11-22},
	journal = {Current Developments in Nutrition},
	author = {Sandoval-Insausti, Helena and Bayan-Bravo, Ana and Donat-Vargas, Carolina and Rey-Garcia, Jimena and Banegas, Jose Ramon and Rodriguez-Artalejo, Fernando and Guallar-Castillon Q2818013A, Pilar},
	month = jun,
	year = {2020},
	pmcid = {PMC7257899},
	pages = {562--562},
}
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