@article{RN209,
   author = {Sano, M. B. and Salmanzadeh, A. and Davalos, R. V.},
   title = {Multilayer contactless dielectrophoresis: theoretical considerations},
   journal = {Electrophoresis},
   volume = {33},
   number = {13},
   pages = {1938-46},
   note = {1522-2683
Sano, Michael B
Salmanzadeh, Alireza
Davalos, Rafael V
Journal Article
Research Support, Non-U.S. Gov't
Germany
2012/07/19
Electrophoresis. 2012 Jul;33(13):1938-46. doi: 10.1002/elps.201100677.},
   abstract = {Dielectrophoresis (DEP), the movement of dielectric particles in a nonuniform electric field, is of particular interest due to its ability to manipulate particles based on their unique electrical properties. Contactless DEP (cDEP) is an extension of traditional and insulator-based DEP topologies. The devices consist of a sample channel and fluid electrode channels filled with a highly conductive media. A thin insulating membrane between the sample channel and the fluid electrode channels serves to isolate the sample from direct contact with metal electrodes. Here we investigate, for the first time, the properties of multilayer devices in which the sample and electrode channels occupy distinct layers. Simulations are conducted using commercially available finite element software and a less computationally demanding numerical approximation is presented and validated. We show that devices can be created that achieve a similar level of electrical performance to other cDEP devices presented in the literature while increasing fluid throughput. We conclude, based on these models, that the ultimate limiting factors in device performance resides in breakdown voltage of the barrier material and the ability to generate high-voltage, high-frequency signals. Finally, we demonstrate trapping of MDA-MB-231 breast cancer cells in a prototype device at a flow rate of 1.0 mL/h when 250 V(RMS) at 600 kHz is applied.},
   keywords = {Cell Line, Tumor
Cell Separation/instrumentation/methods
Computer Simulation
Electric Conductivity
Electrophoresis/*instrumentation/*methods
Humans
*Models, Theoretical
Reproducibility of Results},
   ISSN = {0173-0835},
   DOI = {10.1002/elps.201100677},
   year = {2012},
   type = {Journal Article}
}

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V."],"bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Sano"],"firstnames":["M.","B."],"suffixes":[]},{"propositions":[],"lastnames":["Salmanzadeh"],"firstnames":["A."],"suffixes":[]},{"propositions":[],"lastnames":["Davalos"],"firstnames":["R.","V."],"suffixes":[]}],"title":"Multilayer contactless dielectrophoresis: theoretical considerations","journal":"Electrophoresis","volume":"33","number":"13","pages":"1938-46","note":"1522-2683 Sano, Michael B Salmanzadeh, Alireza Davalos, Rafael V Journal Article Research Support, Non-U.S. Gov't Germany 2012/07/19 Electrophoresis. 2012 Jul;33(13):1938-46. doi: 10.1002/elps.201100677.","abstract":"Dielectrophoresis (DEP), the movement of dielectric particles in a nonuniform electric field, is of particular interest due to its ability to manipulate particles based on their unique electrical properties. Contactless DEP (cDEP) is an extension of traditional and insulator-based DEP topologies. The devices consist of a sample channel and fluid electrode channels filled with a highly conductive media. A thin insulating membrane between the sample channel and the fluid electrode channels serves to isolate the sample from direct contact with metal electrodes. Here we investigate, for the first time, the properties of multilayer devices in which the sample and electrode channels occupy distinct layers. Simulations are conducted using commercially available finite element software and a less computationally demanding numerical approximation is presented and validated. We show that devices can be created that achieve a similar level of electrical performance to other cDEP devices presented in the literature while increasing fluid throughput. We conclude, based on these models, that the ultimate limiting factors in device performance resides in breakdown voltage of the barrier material and the ability to generate high-voltage, high-frequency signals. Finally, we demonstrate trapping of MDA-MB-231 breast cancer cells in a prototype device at a flow rate of 1.0 mL/h when 250 V(RMS) at 600 kHz is applied.","keywords":"Cell Line, Tumor Cell Separation/instrumentation/methods Computer Simulation Electric Conductivity Electrophoresis/*instrumentation/*methods Humans *Models, Theoretical Reproducibility of Results","issn":"0173-0835","doi":"10.1002/elps.201100677","year":"2012","bibtex":"@article{RN209,\n author = {Sano, M. B. and Salmanzadeh, A. and Davalos, R. V.},\n title = {Multilayer contactless dielectrophoresis: theoretical considerations},\n journal = {Electrophoresis},\n volume = {33},\n number = {13},\n pages = {1938-46},\n note = {1522-2683\nSano, Michael B\nSalmanzadeh, Alireza\nDavalos, Rafael V\nJournal Article\nResearch Support, Non-U.S. Gov't\nGermany\n2012/07/19\nElectrophoresis. 2012 Jul;33(13):1938-46. doi: 10.1002/elps.201100677.},\n abstract = {Dielectrophoresis (DEP), the movement of dielectric particles in a nonuniform electric field, is of particular interest due to its ability to manipulate particles based on their unique electrical properties. Contactless DEP (cDEP) is an extension of traditional and insulator-based DEP topologies. The devices consist of a sample channel and fluid electrode channels filled with a highly conductive media. A thin insulating membrane between the sample channel and the fluid electrode channels serves to isolate the sample from direct contact with metal electrodes. Here we investigate, for the first time, the properties of multilayer devices in which the sample and electrode channels occupy distinct layers. Simulations are conducted using commercially available finite element software and a less computationally demanding numerical approximation is presented and validated. We show that devices can be created that achieve a similar level of electrical performance to other cDEP devices presented in the literature while increasing fluid throughput. We conclude, based on these models, that the ultimate limiting factors in device performance resides in breakdown voltage of the barrier material and the ability to generate high-voltage, high-frequency signals. 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