@article{ santarelli_requirement_2003,
  title = {Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants},
  volume = {301},
  issn = {1095-9203},
  doi = {10.1126/science.1083328},
  abstract = {Various chronic antidepressant treatments increase adult hippocampal neurogenesis, but the functional importance of this phenomenon remains unclear. Here, using genetic and radiological methods, we show that disrupting antidepressant-induced neurogenesis blocks behavioral responses to antidepressants. Serotonin 1A receptor null mice were insensitive to the neurogenic and behavioral effects of fluoxetine, a serotonin selective reuptake inhibitor. X-irradiation of a restricted region of mouse brain containing the hippocampus prevented the neurogenic and behavioral effects of two classes of antidepressants. These findings suggest that the behavioral effects of chronic antidepressants may be mediated by the stimulation of neurogenesis in the hippocampus.},
  language = {eng},
  number = {5634},
  journal = {Science (New York, N.Y.)},
  author = {Santarelli, Luca and Saxe, Michael and Gross, Cornelius and Surget, Alexandre and Battaglia, Fortunato and Dulawa, Stephanie and Weisstaub, Noelia and Lee, James and Duman, Ronald and Arancio, Ottavio and Belzung, Catherine and Hen, René},
  month = {August},
  year = {2003},
  pmid = {12907793},
  keywords = {8-Hydroxy-2-(di-n-propylamino)tetralin, Animals, Antidepressive Agents, Antidepressive Agents, Second-Generation, Antidepressive Agents, Tricyclic, Behavior, Animal, Cell Division, Conditioning (Psychology), Dentate Gyrus, Fear, Feeding Behavior, Fluoxetine, Grooming, Hippocampus, Long-Term Potentiation, Male, Mice, Mice, Knockout, Neurons, Receptors, Serotonin, Receptors, Serotonin, 5-{HT}1, Stress, Physiological, Synaptic Transmission},
  pages = {805--809}
}

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X-irradiation of a restricted region of mouse brain containing the hippocampus prevented the neurogenic and behavioral effects of two classes of antidepressants. These findings suggest that the behavioral effects of chronic antidepressants may be mediated by the stimulation of neurogenesis in the hippocampus.","author":["Santarelli, Luca","Saxe, Michael","Gross, Cornelius","Surget, Alexandre","Battaglia, Fortunato","Dulawa, Stephanie","Weisstaub, Noelia","Lee, James","Duman, Ronald","Arancio, Ottavio","Belzung, Catherine","Hen, René"],"author_short":["Santarelli, L.","Saxe, M.","Gross, C.","Surget, A.","Battaglia, F.","Dulawa, S.","Weisstaub, N.","Lee, J.","Duman, R.","Arancio, O.","Belzung, C.","Hen, R."],"bibtex":"@article{ santarelli_requirement_2003,\n title = {Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants},\n volume = {301},\n issn = {1095-9203},\n doi = {10.1126/science.1083328},\n abstract = {Various chronic antidepressant treatments increase adult hippocampal neurogenesis, but the functional importance of this phenomenon remains unclear. Here, using genetic and radiological methods, we show that disrupting antidepressant-induced neurogenesis blocks behavioral responses to antidepressants. Serotonin 1A receptor null mice were insensitive to the neurogenic and behavioral effects of fluoxetine, a serotonin selective reuptake inhibitor. X-irradiation of a restricted region of mouse brain containing the hippocampus prevented the neurogenic and behavioral effects of two classes of antidepressants. These findings suggest that the behavioral effects of chronic antidepressants may be mediated by the stimulation of neurogenesis in the hippocampus.},\n language = {eng},\n number = {5634},\n journal = {Science (New York, N.Y.)},\n author = {Santarelli, Luca and Saxe, Michael and Gross, Cornelius and Surget, Alexandre and Battaglia, Fortunato and Dulawa, Stephanie and Weisstaub, Noelia and Lee, James and Duman, Ronald and Arancio, Ottavio and Belzung, Catherine and Hen, René},\n month = {August},\n year = {2003},\n pmid = {12907793},\n keywords = {8-Hydroxy-2-(di-n-propylamino)tetralin, Animals, Antidepressive Agents, Antidepressive Agents, Second-Generation, Antidepressive Agents, Tricyclic, Behavior, Animal, Cell Division, Conditioning (Psychology), Dentate Gyrus, Fear, Feeding Behavior, Fluoxetine, Grooming, Hippocampus, Long-Term Potentiation, Male, Mice, Mice, Knockout, Neurons, Receptors, Serotonin, Receptors, Serotonin, 5-{HT}1, Stress, Physiological, Synaptic Transmission},\n pages = {805--809}\n}","bibtype":"article","doi":"10.1126/science.1083328","id":"santarelli_requirement_2003","issn":"1095-9203","journal":"Science (New York, N.Y.)","key":"santarelli_requirement_2003","keywords":"8-Hydroxy-2-(di-n-propylamino)tetralin, Animals, Antidepressive Agents, Antidepressive Agents, Second-Generation, Antidepressive Agents, Tricyclic, Behavior, Animal, Cell Division, Conditioning (Psychology), Dentate Gyrus, Fear, Feeding Behavior, Fluoxetine, Grooming, Hippocampus, Long-Term Potentiation, Male, Mice, Mice, Knockout, Neurons, Receptors, Serotonin, Receptors, Serotonin, 5-HT1, Stress, Physiological, Synaptic Transmission","language":"eng","month":"August","number":"5634","pages":"805--809","pmid":"12907793","title":"Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants","type":"article","volume":"301","year":"2003","bibbaseid":"santarelli-saxe-gross-surget-battaglia-dulawa-weisstaub-lee-duman-arancio-belzung-hen-requirementofhippocampalneurogenesisforthebehavioraleffectsofantidepressants-2003","role":"author","urls":{},"keyword":["8-Hydroxy-2-(di-n-propylamino)tetralin","Animals","Antidepressive Agents","Antidepressive Agents","Second-Generation","Antidepressive Agents","Tricyclic","Behavior","Animal","Cell Division","Conditioning (Psychology)","Dentate Gyrus","Fear","Feeding Behavior","Fluoxetine","Grooming","Hippocampus","Long-Term Potentiation","Male","Mice","Mice","Knockout","Neurons","Receptors","Serotonin","Receptors","Serotonin","5-HT1","Stress","Physiological","Synaptic Transmission"],"downloads":0},"bibtype":"article","biburl":"https://api.zotero.org/users/1159944/collections/E8WPEHKT/items?key=urSIQu4xIZyj2vzMTXEsCcOu&format=bibtex&limit=100","creationDate":"2015-02-11T08:35:10.109Z","downloads":0,"keywords":["8-hydroxy-2-(di-n-propylamino)tetralin","animals","antidepressive agents","antidepressive agents","second-generation","antidepressive agents","tricyclic","behavior","animal","cell division","conditioning (psychology)","dentate gyrus","fear","feeding behavior","fluoxetine","grooming","hippocampus","long-term potentiation","male","mice","mice","knockout","neurons","receptors","serotonin","receptors","serotonin","5-ht1","stress","physiological","synaptic transmission"],"search_terms":["requirement","hippocampal","neurogenesis","behavioral","effects","antidepressants","santarelli","saxe","gross","surget","battaglia","dulawa","weisstaub","lee","duman","arancio","belzung","hen"],"title":"Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants","year":2003,"dataSources":["dmyFHrN3jfT2RKa7k"]}