Prevalence of mental disorders among people with opioid use disorder: A systematic review and meta-analysis. Santo, T., Campbell, G., Gisev, N., Martino-Burke, D., Wilson, J., Colledge-Frisby, S., Clark, B., Tran, L. T., & Degenhardt, L. Drug and Alcohol Dependence, 238:109551, September, 2022. ![Prevalence of mental disorders among people with opioid use disorder: A systematic review and meta-analysis [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Background Opioid use disorder (OUD) and mental disorders are major public health issues and comorbidity is common. Among people with OUD, comorbid mental disorders are associated with poorer health outcomes. To our knowledge, this is the first systematic review and meta-analysis to estimate prevalence of specific mental disorders among people with OUD. Methods We searched Embase, MEDLINE, and PsycInfo from 1990 to 2021 for observational studies of depression, anxiety, post-traumatic stress disorder (PTSD), bipolar, personality, and other pre-specified mental disorders among people with OUD. We pooled current and lifetime estimates of each disorder using random-effects meta-analyses with 95% Confidence Intervals (CIs). Meta-regressions and stratified analyses were used to assess heterogeneity of prevalence estimates by methodological factors and sample characteristics. Findings Of the 36,971 publications identified, we included data from 345 studies and 104,135 people with OUD in at least one pooled estimate. Among people with OUD, the prevalence of current depression was 36.1% (95%CI 32.4–39.7%), anxiety was 29.1% (95%CI 24.0–33.3%), attention-deficit/hyperactivity disorder was 20.9% (95%CI 15.7–26.2%), PTSD was 18.1% (95%CI 15.4–20.9%), and bipolar disorder was 8.7% (95%CI 6.7–10.7%). Lifetime prevalence of anti-social personality disorder was 33.6% (95%CI 29.1–38.0%) and borderline personality disorder was 18.2% (95% CI 13.4–23.1%). Sample characteristics and methodological factors, including sex, were associated with variance of multiple prevalence estimates. Interpretation Our findings emphasise the need for access to mental disorder treatment among people with OUD. Specific mental disorder estimates may inform clinical guidelines, treatment services, and future research for people with OUD, including subpopulations with distinct treatment needs.
@article{santo_prevalence_2022,
title = {Prevalence of mental disorders among people with opioid use disorder: {A} systematic review and meta-analysis},
volume = {238},
issn = {0376-8716},
shorttitle = {Prevalence of mental disorders among people with opioid use disorder},
url = {https://www.sciencedirect.com/science/article/pii/S0376871622002885},
doi = {10.1016/j.drugalcdep.2022.109551},
abstract = {Background
Opioid use disorder (OUD) and mental disorders are major public health issues and comorbidity is common. Among people with OUD, comorbid mental disorders are associated with poorer health outcomes. To our knowledge, this is the first systematic review and meta-analysis to estimate prevalence of specific mental disorders among people with OUD.
Methods
We searched Embase, MEDLINE, and PsycInfo from 1990 to 2021 for observational studies of depression, anxiety, post-traumatic stress disorder (PTSD), bipolar, personality, and other pre-specified mental disorders among people with OUD. We pooled current and lifetime estimates of each disorder using random-effects meta-analyses with 95\% Confidence Intervals (CIs). Meta-regressions and stratified analyses were used to assess heterogeneity of prevalence estimates by methodological factors and sample characteristics.
Findings
Of the 36,971 publications identified, we included data from 345 studies and 104,135 people with OUD in at least one pooled estimate. Among people with OUD, the prevalence of current depression was 36.1\% (95\%CI 32.4–39.7\%), anxiety was 29.1\% (95\%CI 24.0–33.3\%), attention-deficit/hyperactivity disorder was 20.9\% (95\%CI 15.7–26.2\%), PTSD was 18.1\% (95\%CI 15.4–20.9\%), and bipolar disorder was 8.7\% (95\%CI 6.7–10.7\%). Lifetime prevalence of anti-social personality disorder was 33.6\% (95\%CI 29.1–38.0\%) and borderline personality disorder was 18.2\% (95\% CI 13.4–23.1\%). Sample characteristics and methodological factors, including sex, were associated with variance of multiple prevalence estimates.
Interpretation
Our findings emphasise the need for access to mental disorder treatment among people with OUD. Specific mental disorder estimates may inform clinical guidelines, treatment services, and future research for people with OUD, including subpopulations with distinct treatment needs.},
language = {en},
urldate = {2022-09-01},
journal = {Drug and Alcohol Dependence},
author = {Santo, Thomas and Campbell, Gabrielle and Gisev, Natasa and Martino-Burke, Daniel and Wilson, Jack and Colledge-Frisby, Samantha and Clark, Brodie and Tran, Lucy Thi and Degenhardt, Louisa},
month = sep,
year = {2022},
keywords = {Anxiety disorders, Mental disorders, Meta-analysis, Mood disorders, Opioid use disorders, Systematic review},
pages = {109551},
}
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To our knowledge, this is the first systematic review and meta-analysis to estimate prevalence of specific mental disorders among people with OUD. Methods We searched Embase, MEDLINE, and PsycInfo from 1990 to 2021 for observational studies of depression, anxiety, post-traumatic stress disorder (PTSD), bipolar, personality, and other pre-specified mental disorders among people with OUD. We pooled current and lifetime estimates of each disorder using random-effects meta-analyses with 95% Confidence Intervals (CIs). Meta-regressions and stratified analyses were used to assess heterogeneity of prevalence estimates by methodological factors and sample characteristics. Findings Of the 36,971 publications identified, we included data from 345 studies and 104,135 people with OUD in at least one pooled estimate. Among people with OUD, the prevalence of current depression was 36.1% (95%CI 32.4–39.7%), anxiety was 29.1% (95%CI 24.0–33.3%), attention-deficit/hyperactivity disorder was 20.9% (95%CI 15.7–26.2%), PTSD was 18.1% (95%CI 15.4–20.9%), and bipolar disorder was 8.7% (95%CI 6.7–10.7%). Lifetime prevalence of anti-social personality disorder was 33.6% (95%CI 29.1–38.0%) and borderline personality disorder was 18.2% (95% CI 13.4–23.1%). Sample characteristics and methodological factors, including sex, were associated with variance of multiple prevalence estimates. Interpretation Our findings emphasise the need for access to mental disorder treatment among people with OUD. Specific mental disorder estimates may inform clinical guidelines, treatment services, and future research for people with OUD, including subpopulations with distinct treatment needs.","language":"en","urldate":"2022-09-01","journal":"Drug and Alcohol Dependence","author":[{"propositions":[],"lastnames":["Santo"],"firstnames":["Thomas"],"suffixes":[]},{"propositions":[],"lastnames":["Campbell"],"firstnames":["Gabrielle"],"suffixes":[]},{"propositions":[],"lastnames":["Gisev"],"firstnames":["Natasa"],"suffixes":[]},{"propositions":[],"lastnames":["Martino-Burke"],"firstnames":["Daniel"],"suffixes":[]},{"propositions":[],"lastnames":["Wilson"],"firstnames":["Jack"],"suffixes":[]},{"propositions":[],"lastnames":["Colledge-Frisby"],"firstnames":["Samantha"],"suffixes":[]},{"propositions":[],"lastnames":["Clark"],"firstnames":["Brodie"],"suffixes":[]},{"propositions":[],"lastnames":["Tran"],"firstnames":["Lucy","Thi"],"suffixes":[]},{"propositions":[],"lastnames":["Degenhardt"],"firstnames":["Louisa"],"suffixes":[]}],"month":"September","year":"2022","keywords":"Anxiety disorders, Mental disorders, Meta-analysis, Mood disorders, Opioid use disorders, Systematic review","pages":"109551","bibtex":"@article{santo_prevalence_2022,\n\ttitle = {Prevalence of mental disorders among people with opioid use disorder: {A} systematic review and meta-analysis},\n\tvolume = {238},\n\tissn = {0376-8716},\n\tshorttitle = {Prevalence of mental disorders among people with opioid use disorder},\n\turl = {https://www.sciencedirect.com/science/article/pii/S0376871622002885},\n\tdoi = {10.1016/j.drugalcdep.2022.109551},\n\tabstract = {Background\nOpioid use disorder (OUD) and mental disorders are major public health issues and comorbidity is common. Among people with OUD, comorbid mental disorders are associated with poorer health outcomes. To our knowledge, this is the first systematic review and meta-analysis to estimate prevalence of specific mental disorders among people with OUD.\nMethods\nWe searched Embase, MEDLINE, and PsycInfo from 1990 to 2021 for observational studies of depression, anxiety, post-traumatic stress disorder (PTSD), bipolar, personality, and other pre-specified mental disorders among people with OUD. We pooled current and lifetime estimates of each disorder using random-effects meta-analyses with 95\\% Confidence Intervals (CIs). Meta-regressions and stratified analyses were used to assess heterogeneity of prevalence estimates by methodological factors and sample characteristics.\nFindings\nOf the 36,971 publications identified, we included data from 345 studies and 104,135 people with OUD in at least one pooled estimate. Among people with OUD, the prevalence of current depression was 36.1\\% (95\\%CI 32.4–39.7\\%), anxiety was 29.1\\% (95\\%CI 24.0–33.3\\%), attention-deficit/hyperactivity disorder was 20.9\\% (95\\%CI 15.7–26.2\\%), PTSD was 18.1\\% (95\\%CI 15.4–20.9\\%), and bipolar disorder was 8.7\\% (95\\%CI 6.7–10.7\\%). Lifetime prevalence of anti-social personality disorder was 33.6\\% (95\\%CI 29.1–38.0\\%) and borderline personality disorder was 18.2\\% (95\\% CI 13.4–23.1\\%). Sample characteristics and methodological factors, including sex, were associated with variance of multiple prevalence estimates.\nInterpretation\nOur findings emphasise the need for access to mental disorder treatment among people with OUD. Specific mental disorder estimates may inform clinical guidelines, treatment services, and future research for people with OUD, including subpopulations with distinct treatment needs.},\n\tlanguage = {en},\n\turldate = {2022-09-01},\n\tjournal = {Drug and Alcohol Dependence},\n\tauthor = {Santo, Thomas and Campbell, Gabrielle and Gisev, Natasa and Martino-Burke, Daniel and Wilson, Jack and Colledge-Frisby, Samantha and Clark, Brodie and Tran, Lucy Thi and Degenhardt, Louisa},\n\tmonth = sep,\n\tyear = {2022},\n\tkeywords = {Anxiety disorders, Mental disorders, Meta-analysis, Mood disorders, Opioid use disorders, Systematic review},\n\tpages = {109551},\n}\n\n","author_short":["Santo, T.","Campbell, G.","Gisev, N.","Martino-Burke, D.","Wilson, J.","Colledge-Frisby, S.","Clark, B.","Tran, L. 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