A field study of the safety and efficacy of two candidate rotavirus vaccines in a Native American population. Santosham, M, Letson, G W, Wolff, M, Reid, R, Gahagan, S, Adams, R, Callahan, C, Sack, R B, & Kapikian, A Z The Journal of Infectious Diseases, 163(3):483–487, March, 1991.
Paper abstract bibtex A double-blind, randomized, placebo-controlled trial was conducted to evaluate the safety and efficacy of a rhesus rotavirus vaccine and RIT 4237, a bovine rotavirus vaccine, in a Navajo population. Infants aged 2-5 months were randomized to receive one dose of either 10(4) pfu of the rhesus rotavirus vaccine or 10(8) pfu of the RIT 4237 vaccine or placebo. Eleven (10.2%) of 108 infants in the rhesus vaccine group, 11 (10.4%) of 106 in the RIT 4237 group, and 9 (8.4%) of 107 in the placebo group experienced rotavirus diarrhea during the follow-up period of 17 months. Thus, in this population, neither vaccine was efficacious in preventing rotavirus diarrhea.
@article{santosham_field_1991,
title = {A field study of the safety and efficacy of two candidate rotavirus vaccines in a {Native} {American} population},
volume = {163},
issn = {0022-1899},
url = {http://www.ncbi.nlm.nih.gov/pubmed/1995721},
abstract = {A double-blind, randomized, placebo-controlled trial was conducted to evaluate the safety and efficacy of a rhesus rotavirus vaccine and RIT 4237, a bovine rotavirus vaccine, in a Navajo population. Infants aged 2-5 months were randomized to receive one dose of either 10(4) pfu of the rhesus rotavirus vaccine or 10(8) pfu of the RIT 4237 vaccine or placebo. Eleven (10.2\%) of 108 infants in the rhesus vaccine group, 11 (10.4\%) of 106 in the RIT 4237 group, and 9 (8.4\%) of 107 in the placebo group experienced rotavirus diarrhea during the follow-up period of 17 months. Thus, in this population, neither vaccine was efficacious in preventing rotavirus diarrhea.},
number = {3},
urldate = {2011-06-14},
journal = {The Journal of Infectious Diseases},
author = {Santosham, M and Letson, G W and Wolff, M and Reid, R and Gahagan, S and Adams, R and Callahan, C and Sack, R B and Kapikian, A Z},
month = mar,
year = {1991},
pmid = {1995721},
pages = {483--487},
}
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