Post-lunch triglyceridaemia associates with HDLc and insulin resistance in fasting normotriglyceridaemic menopausal women. Sanz-Paris, A., Rodriguez-Valle, A., Navarro, M. A., Puzo-Foncillas, J., & Arbones-Mainar, J. M. Journal of Human Nutrition and Dietetics, 2017. Volume: 30 Issue: 6
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© 2017 The British Dietetic Association Ltd. Objectives: Post-prandial hypertriglyceridaemia (P-HTG) is associated with cardiovascular disease. This association is of paramount importance during menopause, which is also related to reduced high-density lipoprotein-cholesterol (HDLc) and elevated triglyceride (TG) levels. We aimed to provide a self-assesing tool to screen for P-HTG in menopausal women who were normotriglyceridaemic at fasting and adhered to a Mediterranean-style eating pattern. Methods: We performed oral fat loading tests (OFLT) in combination with self-measurements of diurnal capillary TG at fixed time-points (DC-TG) in 29 healthy menopausal women. TG levels \textgreater 220 mg dL -1 at any given time during the OFLT served as diagnostic criteria for P-HTG. Subsequently, DC-TG profiles were examined to determine the best mealtime (breakfast, lunch or dinner), as well as optimal cut-off points to classify these women as having P-HTG according to the OFLT. Insulin resistance was defined as the upper tertile of the homeostatic model assessment of insulin resistance. Results: We found that, despite having normal fasting TG levels, P-HTG was highly prevalent (approximately 40%). Moreover, self-assessed 3-h post-lunch TG levels \textgreater 165 mg dL -1 increased the odds of having hypo-HDL cholesterolaemia by 14.1-fold (P = 0.026) and the odds of having insulin resistance by 31.6-fold (P = 0.007), adjusted for total fat intake in women adhering to a Mediterranean eating pattern having their highest energy intake at lunch. Conclusions: Self-assessed 3-h post-lunch TG can be used to study post-prandial TG metabolism in Southern European menopausal women who are normotriglyceridaemic at fasting. Characterising an individual's post-prandial response may help menopausal women to evaluate their risk of cardiovascular disease.
@article{Sanz-Paris2017,
	title = {Post-lunch triglyceridaemia associates with {HDLc} and insulin resistance in fasting normotriglyceridaemic menopausal women},
	copyright = {All rights reserved},
	issn = {1365277X},
	abstract = {© 2017 The British Dietetic Association Ltd. Objectives: Post-prandial hypertriglyceridaemia (P-HTG) is associated with cardiovascular disease. This association is of paramount importance during menopause, which is also related to reduced high-density lipoprotein-cholesterol (HDLc) and elevated triglyceride (TG) levels. We aimed to provide a self-assesing tool to screen for P-HTG in menopausal women who were normotriglyceridaemic at fasting and adhered to a Mediterranean-style eating pattern. Methods: We performed oral fat loading tests (OFLT) in combination with self-measurements of diurnal capillary TG at fixed time-points (DC-TG) in 29 healthy menopausal women. TG levels {\textgreater} 220 mg dL -1 at any given time during the OFLT served as diagnostic criteria for P-HTG. Subsequently, DC-TG profiles were examined to determine the best mealtime (breakfast, lunch or dinner), as well as optimal cut-off points to classify these women as having P-HTG according to the OFLT. Insulin resistance was defined as the upper tertile of the homeostatic model assessment of insulin resistance. Results: We found that, despite having normal fasting TG levels, P-HTG was highly prevalent (approximately 40\%). Moreover, self-assessed 3-h post-lunch TG levels {\textgreater} 165 mg dL -1 increased the odds of having hypo-HDL cholesterolaemia by 14.1-fold (P = 0.026) and the odds of having insulin resistance by 31.6-fold (P = 0.007), adjusted for total fat intake in women adhering to a Mediterranean eating pattern having their highest energy intake at lunch. Conclusions: Self-assessed 3-h post-lunch TG can be used to study post-prandial TG metabolism in Southern European menopausal women who are normotriglyceridaemic at fasting. Characterising an individual's post-prandial response may help menopausal women to evaluate their risk of cardiovascular disease.},
	journal = {Journal of Human Nutrition and Dietetics},
	author = {Sanz-Paris, A. and Rodriguez-Valle, A. and Navarro, M. A. and Puzo-Foncillas, J. and Arbones-Mainar, J. M.},
	year = {2017},
	doi = {10.1111/jhn.12476},
	note = {Volume: 30
Issue: 6},
	pages = {700--708},
}

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