Single-cell Deconvolution of a Specific Malignant Cell Population as a Poor Prognostic Biomarker in Low-risk Clear Cell Renal Cell Carcinoma Patients. Saout, J. R., Lecuyer, G., Léonard, S., Evrard, B., Kammerer-Jacquet, S., Noël, L., Khene, Z., Mathieu, R., Brunot, A., Rolland, A. D., Bensalah, K., Rioux-Leclercq, N., Lardenois, A., & Chalmel, F. European Urology, 83(5):441–451, May, 2023. ![Single-cell Deconvolution of a Specific Malignant Cell Population as a Poor Prognostic Biomarker in Low-risk Clear Cell Renal Cell Carcinoma Patients [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex BACKGROUND: Intra-tumor heterogeneity (ITH) is a key feature in clear-cell renal cell carcinomas (ccRCCs) which impacts outcomes such as aggressiveness, response to treatments or recurrence. In particular, it may explain tumor relapse after surgery in clinically low-risk patients who did not benefit from adjuvant therapy. Recently, single-cell RNA-seq (scRNA-seq) has emerged as a powerful tool to unravel expression intra-tumor heterogeneity (eITH) and might enable better assessment of clinical outcomes in ccRCC.
@article{saout_single-cell_2023,
title = {Single-cell {Deconvolution} of a {Specific} {Malignant} {Cell} {Population} as a {Poor} {Prognostic} {Biomarker} in {Low}-risk {Clear} {Cell} {Renal} {Cell} {Carcinoma} {Patients}},
volume = {83},
issn = {03022838},
url = {https://linkinghub.elsevier.com/retrieve/pii/S0302283823025800},
doi = {10.1016/j.eururo.2023.02.008},
abstract = {BACKGROUND: Intra-tumor heterogeneity (ITH) is a key feature in clear-cell renal cell carcinomas (ccRCCs) which impacts outcomes such as aggressiveness, response to treatments or recurrence. In particular, it may explain tumor relapse after surgery in clinically low-risk patients who did not benefit from adjuvant therapy. Recently, single-cell RNA-seq (scRNA-seq) has emerged as a powerful tool to unravel expression intra-tumor heterogeneity (eITH) and might enable better assessment of clinical outcomes in ccRCC.},
language = {en},
number = {5},
urldate = {2023-11-29},
journal = {European Urology},
author = {Saout, Judikael R. and Lecuyer, Gwendoline and Léonard, Simon and Evrard, Bertrand and Kammerer-Jacquet, Solène-Florence and Noël, Laurence and Khene, Zine-Eddine and Mathieu, Romain and Brunot, Angélique and Rolland, Antoine D. and Bensalah, Karim and Rioux-Leclercq, Nathalie and Lardenois, Aurélie and Chalmel, Frédéric},
month = may,
year = {2023},
pages = {441--451},
}
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