@article{sarnik_induction_2017,
	title = {The induction of oxidative stress in cervix carcinoma cells by levoglucosenone derived 4-{S}-salicyl derivative and (1-4)-{S}-thio-disaccharides. {Part} 4},
	volume = {27},
	issn = {1464-3405},
	doi = {10.1016/j.bmcl.2017.01.064},
	abstract = {(1-4)-S-thiodisaccharides were shown to kill various cancer cell lines, including cervix, lung, mammary-gland and colon by unknown mechanisms. Here we identified two actions of levoglucosenone derived (1-4)-S-thiodisaccharides against cervix cancer cells: induction of oxidative stress and DNA damage. In consequence, (1-4)-S-thiodisaccharides lowered the cellular GSH level and changed the expression profile of genes encoding key proteins involved with oxidative stress response. We also observed that (1-4)-S-thiodisaccharides induced DNA damage and interfered with the thioredoxin (Trx) system. Both actions, as induced by FPC6, were stronger when dihedral angles of sulfur bridge were set to 110°, 100° and 109°, clearly indicating differences when compared to FPC8. These findings demonstrate that the 1-4-thio bridge of disaccharide is a powerful anticancer pharmacophore, and its potential use needs further studies.},
	language = {eng},
	number = {5},
	journal = {Bioorganic \& Medicinal Chemistry Letters},
	author = {Sarnik, Joanna and Czubatka-Bienkowska, Anna and Macieja, Anna and Bielski, Roman and Witczak, Zbigniew J. and Poplawski, Tomasz},
	year = {2017},
	pmid = {28185719},
	keywords = {(1–4)-S-thiodisaccharides, Bridged Bicyclo Compounds, Heterocyclic, DNA Damage, DNA damage, Disaccharides, Female, Functional CARB-pharmacophore, Glucose, Humans, Oxidative Stress, Oxidative stress, Reactive Oxygen Species, Reactive oxygen species, Uterine Cervical Neoplasms},
	pages = {1215--1219},
}

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Part 4","volume":"27","issn":"1464-3405","doi":"10.1016/j.bmcl.2017.01.064","abstract":"(1-4)-S-thiodisaccharides were shown to kill various cancer cell lines, including cervix, lung, mammary-gland and colon by unknown mechanisms. Here we identified two actions of levoglucosenone derived (1-4)-S-thiodisaccharides against cervix cancer cells: induction of oxidative stress and DNA damage. In consequence, (1-4)-S-thiodisaccharides lowered the cellular GSH level and changed the expression profile of genes encoding key proteins involved with oxidative stress response. We also observed that (1-4)-S-thiodisaccharides induced DNA damage and interfered with the thioredoxin (Trx) system. Both actions, as induced by FPC6, were stronger when dihedral angles of sulfur bridge were set to 110°, 100° and 109°, clearly indicating differences when compared to FPC8. These findings demonstrate that the 1-4-thio bridge of disaccharide is a powerful anticancer pharmacophore, and its potential use needs further studies.","language":"eng","number":"5","journal":"Bioorganic & Medicinal Chemistry Letters","author":[{"propositions":[],"lastnames":["Sarnik"],"firstnames":["Joanna"],"suffixes":[]},{"propositions":[],"lastnames":["Czubatka-Bienkowska"],"firstnames":["Anna"],"suffixes":[]},{"propositions":[],"lastnames":["Macieja"],"firstnames":["Anna"],"suffixes":[]},{"propositions":[],"lastnames":["Bielski"],"firstnames":["Roman"],"suffixes":[]},{"propositions":[],"lastnames":["Witczak"],"firstnames":["Zbigniew","J."],"suffixes":[]},{"propositions":[],"lastnames":["Poplawski"],"firstnames":["Tomasz"],"suffixes":[]}],"year":"2017","pmid":"28185719","keywords":"(1–4)-S-thiodisaccharides, Bridged Bicyclo Compounds, Heterocyclic, DNA Damage, DNA damage, Disaccharides, Female, Functional CARB-pharmacophore, Glucose, Humans, Oxidative Stress, Oxidative stress, Reactive Oxygen Species, Reactive oxygen species, Uterine Cervical Neoplasms","pages":"1215–1219","bibtex":"@article{sarnik_induction_2017,\n\ttitle = {The induction of oxidative stress in cervix carcinoma cells by levoglucosenone derived 4-{S}-salicyl derivative and (1-4)-{S}-thio-disaccharides. {Part} 4},\n\tvolume = {27},\n\tissn = {1464-3405},\n\tdoi = {10.1016/j.bmcl.2017.01.064},\n\tabstract = {(1-4)-S-thiodisaccharides were shown to kill various cancer cell lines, including cervix, lung, mammary-gland and colon by unknown mechanisms. Here we identified two actions of levoglucosenone derived (1-4)-S-thiodisaccharides against cervix cancer cells: induction of oxidative stress and DNA damage. In consequence, (1-4)-S-thiodisaccharides lowered the cellular GSH level and changed the expression profile of genes encoding key proteins involved with oxidative stress response. We also observed that (1-4)-S-thiodisaccharides induced DNA damage and interfered with the thioredoxin (Trx) system. Both actions, as induced by FPC6, were stronger when dihedral angles of sulfur bridge were set to 110°, 100° and 109°, clearly indicating differences when compared to FPC8. 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