Small separation diffuse correlation spectroscopy for measurement of cerebral blood flow in rodents. Sathialingam, E., Lee, S. Y., Sanders, B., Park, J., McCracken, C. E., Bryan, L., & Buckley, E. M. Biomedical Optics Express, 9(11):5719–5734, November, 2018.
doi  abstract   bibtex   
Diffuse correlation spectroscopy (DCS) has shown promise as a means to non-invasively measure cerebral blood flow in small animal models. Here, we characterize the validity of DCS at small source-detector reflectance separations needed for small animal measurements. Through Monte Carlo simulations and liquid phantom experiments, we show that DCS error increases as separation decreases, although error remains below 12% for separations \textgreater 0.2 cm. In mice, DCS measures of cerebral blood flow have excellent intra-user repeatability and strongly correlate with MRI measures of blood flow (R = 0.74, p\textless0.01). These results are generalizable to other DCS applications wherein short-separation reflectance geometries are desired.
@article{sathialingam_small_2018,
	title = {Small separation diffuse correlation spectroscopy for measurement of cerebral blood flow in rodents},
	volume = {9},
	issn = {2156-7085},
	doi = {10.1364/BOE.9.005719},
	abstract = {Diffuse correlation spectroscopy (DCS) has shown promise as a means to non-invasively measure cerebral blood flow in small animal models. Here, we characterize the validity of DCS at small source-detector reflectance separations needed for small animal measurements. Through Monte Carlo simulations and liquid phantom experiments, we show that DCS error increases as separation decreases, although error remains below 12\% for separations {\textgreater} 0.2 cm. In mice, DCS measures of cerebral blood flow have excellent intra-user repeatability and strongly correlate with MRI measures of blood flow (R = 0.74, p{\textless}0.01). These results are generalizable to other DCS applications wherein short-separation reflectance geometries are desired.},
	language = {eng},
	number = {11},
	journal = {Biomedical Optics Express},
	author = {Sathialingam, Eashani and Lee, Seung Yup and Sanders, Bharat and Park, Jaekeun and McCracken, Courtney E. and Bryan, Leah and Buckley, Erin M.},
	month = nov,
	year = {2018},
	pmid = {30460158},
	pmcid = {PMC6238900},
	pages = {5719--5734},
}

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