@article{Scheepers2022,
abstract = {Global genomic surveillance of SARS-CoV-2 has identified variants associated with increased transmissibility, neutralization resistance and disease severity. Here we report the emergence of the PANGO lineage C.1.2, detected at low prevalence in South Africa and eleven other countries. The initial C.1.2 detection is associated with a high substitution rate, and includes changes within the spike protein that have been associated with increased transmissibility or reduced neutralization sensitivity in SARS-CoV-2 variants of concern or variants of interest. Like Beta and Delta, C.1.2 shows significantly reduced neutralization sensitivity to plasma from vaccinees and individuals infected with the ancestral D614G virus. In contrast, convalescent donors infected with either Beta or Delta show high plasma neutralization against C.1.2. These functional data suggest that vaccine efficacy against C.1.2 will be equivalent to Beta and Delta, and that prior infection with either Beta or Delta will likely offer protection against C.1.2. The SARS-CoV-2 PANGO lineage C.1.2 has been under monitoring by global health authorities as it has spread worldwide. Here, Bhiman and colleagues characterise the emergence of the lineage, and its neutralisation sensitivity using data from vaccinees and previously infected individuals.},
author = {Scheepers, Cathrine and Everatt, Josie and Amoako, Daniel G and Tegally, Houriiyah and Wibmer, Constantinos Kurt and Mnguni, Anele and Ismail, Arshad and Mahlangu, Boitshoko and Lambson, Bronwen E and Martin, Darren P and Wilkinson, Eduan and San, James Emmanuel and Giandhari, Jennifer and Manamela, Nelia and Ntuli, Noxolo and Kgagudi, Prudence and Cele, Sandile and Richardson, Simone I and Pillay, Sureshnee and Mohale, Thabo and Ramphal, Upasana and Naidoo, Yeshnee and Khumalo, Zamantungwa T and Kwatra, Gaurav and Gray, Glenda and Bekker, Linda-Gail and Madhi, Shabir A and Baillie, Vicky and {Van Voorhis}, Wesley C and Treurnicht, Florette K and Venter, Marietjie and Mlisana, Koleka and Wolter, Nicole and Sigal, Alex and Williamson, Carolyn and Hsiao, Nei-yuan and Msomi, Nokukhanya and Maponga, Tongai and Preiser, Wolfgang and Makatini, Zinhle and Lessells, Richard and Moore, Penny L and de Oliveira, Tulio and von Gottberg, Anne and Bhiman, Jinal N},
doi = {10.1038/s41467-022-29579-9},
file = {:C$\backslash$:/Users/01462563/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Scheepers et al. - 2022 - Emergence and phenotypic characterization of the global SARS-CoV-2 C.1.2 lineage.pdf:pdf},
issn = {2041-1723},
journal = {Nature Communications},
keywords = {2,CoV,Epidemiology,OA,SARS,Viral infection,genomics{\_}fund{\_}ack,original},
mendeley-tags = {OA,genomics{\_}fund{\_}ack,original},
month = {apr},
pages = {1976},
pmid = {35396511},
publisher = {Nature Publishing Group},
title = {{Emergence and phenotypic characterization of the global SARS-CoV-2 C.1.2 lineage}},
url = {https://www.nature.com/articles/s41467-022-29579-9},
volume = {13},
year = {2022}
}

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