@article{RN146,
   author = {Scheltema, M. J. and O'Brien, T. J. and van den Bos, W. and de Bruin, D. M. and Davalos, R. V. and van den Geld, C. W. M. and Laguna, M. P. and Neal, R. E., 2nd and Varkarakis, I. M. and Skolarikos, A. and Stricker, P. D. and de Reijke, T. M. and Arena, C. B. and de la Rosette, J.},
   title = {Numerical simulation modeling of the irreversible electroporation treatment zone for focal therapy of prostate cancer, correlation with whole-mount pathology and T2-weighted MRI sequences},
   journal = {Ther Adv Urol},
   volume = {11},
   pages = {1756287219852305},
   note = {1756-2880
Scheltema, Matthijs J
Orcid: 0000-0002-9098-9574
O'Brien, Tim J
van den Bos, Willemien
de Bruin, Daniel M
Davalos, Rafael V
van den Geld, Cees W M
Laguna, Maria P
Neal, Robert E 2nd
Varkarakis, Ioannis M
Skolarikos, Andreas
Stricker, Phillip D
de Reijke, Theo M
Arena, Christopher B
de la Rosette, Jean
Journal Article
England
2019/06/21
Ther Adv Urol. 2019 Jun 7;11:1756287219852305. doi: 10.1177/1756287219852305. eCollection 2019 Jan-Dec.},
   abstract = {BACKGROUND: At present, it is not possible to predict the ablation zone volume following irreversible electroporation (IRE) for prostate cancer (PCa). This study aimed to determine the necessary electrical field threshold to ablate human prostate tissue in vivo with IRE. METHODS: In this prospective multicenter trial, patients with localized PCa were treated with IRE 4 weeks before their scheduled radical prostatectomy. In 13 patients, numerical models of the electrical field were generated and compared with the ablation zone volume on whole-mount pathology and T2-weighted magnetic resonance imaging (MRI) sequences. Volume-generating software was used to calculate the ablation zone volumes on histology and MRI. The electric field threshold to ablate prostate tissue was determined for each patient. RESULTS: A total of 13 patients were included for histological and simulation analysis. The median electrical field threshold was 550 V/cm (interquartile range 383-750 V/cm) for the software-generated histology volumes. The median electrical field threshold was 500 V/cm (interquartile range 386-580 V/cm) when the ablation zone volumes were used from the follow-up MRI. CONCLUSIONS: The electrical field threshold to ablate human prostate tissue in vivo was determined using whole-mount pathology and MRI. These thresholds may be used to develop treatment planning or monitoring software for IRE prostate ablation; however, further optimization of simulation methods are required to decrease the variance that was observed between patients.},
   keywords = {electrical field
focal therapy
irreversible electroporation
prostate
prostate cancer
simulation},
   ISSN = {1756-2872 (Print)
1756-2872},
   DOI = {10.1177/1756287219852305},
   year = {2019},
   type = {Journal Article}
}

{"_id":"Yih4PmeusR7EGCDYt","bibbaseid":"scheltema-obrien-vandenbos-debruin-davalos-vandengeld-laguna-neal-etal-numericalsimulationmodelingoftheirreversibleelectroporationtreatmentzoneforfocaltherapyofprostatecancercorrelationwithwholemountpathologyandt2weightedmrisequences-2019","author_short":["Scheltema, M. J.","O'Brien, T. J.","van den Bos, W.","de Bruin, D. M.","Davalos, R. V.","van den Geld, C. W. M.","Laguna, M. P.","Neal, R. E.","Varkarakis, I. M.","Skolarikos, A.","Stricker, P. D.","de Reijke, T. M.","Arena, C. B.","de la Rosette, J."],"bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Scheltema"],"firstnames":["M.","J."],"suffixes":[]},{"propositions":[],"lastnames":["O'Brien"],"firstnames":["T.","J."],"suffixes":[]},{"propositions":["van","den"],"lastnames":["Bos"],"firstnames":["W."],"suffixes":[]},{"propositions":["de"],"lastnames":["Bruin"],"firstnames":["D.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Davalos"],"firstnames":["R.","V."],"suffixes":[]},{"propositions":["van","den"],"lastnames":["Geld"],"firstnames":["C.","W.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Laguna"],"firstnames":["M.","P."],"suffixes":[]},{"propositions":[],"lastnames":["Neal"],"firstnames":["R.","E."],"suffixes":["2nd"]},{"propositions":[],"lastnames":["Varkarakis"],"firstnames":["I.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Skolarikos"],"firstnames":["A."],"suffixes":[]},{"propositions":[],"lastnames":["Stricker"],"firstnames":["P.","D."],"suffixes":[]},{"propositions":["de"],"lastnames":["Reijke"],"firstnames":["T.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Arena"],"firstnames":["C.","B."],"suffixes":[]},{"propositions":["de","la"],"lastnames":["Rosette"],"firstnames":["J."],"suffixes":[]}],"title":"Numerical simulation modeling of the irreversible electroporation treatment zone for focal therapy of prostate cancer, correlation with whole-mount pathology and T2-weighted MRI sequences","journal":"Ther Adv Urol","volume":"11","pages":"1756287219852305","note":"1756-2880 Scheltema, Matthijs J Orcid: 0000-0002-9098-9574 O'Brien, Tim J van den Bos, Willemien de Bruin, Daniel M Davalos, Rafael V van den Geld, Cees W M Laguna, Maria P Neal, Robert E 2nd Varkarakis, Ioannis M Skolarikos, Andreas Stricker, Phillip D de Reijke, Theo M Arena, Christopher B de la Rosette, Jean Journal Article England 2019/06/21 Ther Adv Urol. 2019 Jun 7;11:1756287219852305. doi: 10.1177/1756287219852305. eCollection 2019 Jan-Dec.","abstract":"BACKGROUND: At present, it is not possible to predict the ablation zone volume following irreversible electroporation (IRE) for prostate cancer (PCa). This study aimed to determine the necessary electrical field threshold to ablate human prostate tissue in vivo with IRE. METHODS: In this prospective multicenter trial, patients with localized PCa were treated with IRE 4 weeks before their scheduled radical prostatectomy. In 13 patients, numerical models of the electrical field were generated and compared with the ablation zone volume on whole-mount pathology and T2-weighted magnetic resonance imaging (MRI) sequences. Volume-generating software was used to calculate the ablation zone volumes on histology and MRI. The electric field threshold to ablate prostate tissue was determined for each patient. RESULTS: A total of 13 patients were included for histological and simulation analysis. The median electrical field threshold was 550 V/cm (interquartile range 383-750 V/cm) for the software-generated histology volumes. The median electrical field threshold was 500 V/cm (interquartile range 386-580 V/cm) when the ablation zone volumes were used from the follow-up MRI. CONCLUSIONS: The electrical field threshold to ablate human prostate tissue in vivo was determined using whole-mount pathology and MRI. These thresholds may be used to develop treatment planning or monitoring software for IRE prostate ablation; however, further optimization of simulation methods are required to decrease the variance that was observed between patients.","keywords":"electrical field focal therapy irreversible electroporation prostate prostate cancer simulation","issn":"1756-2872 (Print) 1756-2872","doi":"10.1177/1756287219852305","year":"2019","bibtex":"@article{RN146,\n author = {Scheltema, M. J. and O'Brien, T. J. and van den Bos, W. and de Bruin, D. M. and Davalos, R. V. and van den Geld, C. W. M. and Laguna, M. P. and Neal, R. E., 2nd and Varkarakis, I. M. and Skolarikos, A. and Stricker, P. D. and de Reijke, T. M. and Arena, C. B. and de la Rosette, J.},\n title = {Numerical simulation modeling of the irreversible electroporation treatment zone for focal therapy of prostate cancer, correlation with whole-mount pathology and T2-weighted MRI sequences},\n journal = {Ther Adv Urol},\n volume = {11},\n pages = {1756287219852305},\n note = {1756-2880\nScheltema, Matthijs J\nOrcid: 0000-0002-9098-9574\nO'Brien, Tim J\nvan den Bos, Willemien\nde Bruin, Daniel M\nDavalos, Rafael V\nvan den Geld, Cees W M\nLaguna, Maria P\nNeal, Robert E 2nd\nVarkarakis, Ioannis M\nSkolarikos, Andreas\nStricker, Phillip D\nde Reijke, Theo M\nArena, Christopher B\nde la Rosette, Jean\nJournal Article\nEngland\n2019/06/21\nTher Adv Urol. 2019 Jun 7;11:1756287219852305. doi: 10.1177/1756287219852305. eCollection 2019 Jan-Dec.},\n abstract = {BACKGROUND: At present, it is not possible to predict the ablation zone volume following irreversible electroporation (IRE) for prostate cancer (PCa). This study aimed to determine the necessary electrical field threshold to ablate human prostate tissue in vivo with IRE. METHODS: In this prospective multicenter trial, patients with localized PCa were treated with IRE 4 weeks before their scheduled radical prostatectomy. In 13 patients, numerical models of the electrical field were generated and compared with the ablation zone volume on whole-mount pathology and T2-weighted magnetic resonance imaging (MRI) sequences. Volume-generating software was used to calculate the ablation zone volumes on histology and MRI. The electric field threshold to ablate prostate tissue was determined for each patient. RESULTS: A total of 13 patients were included for histological and simulation analysis. The median electrical field threshold was 550 V/cm (interquartile range 383-750 V/cm) for the software-generated histology volumes. The median electrical field threshold was 500 V/cm (interquartile range 386-580 V/cm) when the ablation zone volumes were used from the follow-up MRI. CONCLUSIONS: The electrical field threshold to ablate human prostate tissue in vivo was determined using whole-mount pathology and MRI. These thresholds may be used to develop treatment planning or monitoring software for IRE prostate ablation; however, further optimization of simulation methods are required to decrease the variance that was observed between patients.},\n keywords = {electrical field\nfocal therapy\nirreversible electroporation\nprostate\nprostate cancer\nsimulation},\n ISSN = {1756-2872 (Print)\n1756-2872},\n DOI = {10.1177/1756287219852305},\n year = {2019},\n type = {Journal Article}\n}\n\n","author_short":["Scheltema, M. J.","O'Brien, T. J.","van den Bos, W.","de Bruin, D. M.","Davalos, R. V.","van den Geld, C. W. M.","Laguna, M. P.","Neal, R. E.","Varkarakis, I. M.","Skolarikos, A.","Stricker, P. D.","de Reijke, T. M.","Arena, C. B.","de la Rosette, J."],"key":"RN146","id":"RN146","bibbaseid":"scheltema-obrien-vandenbos-debruin-davalos-vandengeld-laguna-neal-etal-numericalsimulationmodelingoftheirreversibleelectroporationtreatmentzoneforfocaltherapyofprostatecancercorrelationwithwholemountpathologyandt2weightedmrisequences-2019","role":"author","urls":{},"keyword":["electrical field focal therapy irreversible electroporation prostate prostate cancer simulation"],"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://bibbase.org/network/files/bdNBTZRXTsoHCgpbh","dataSources":["D4zENc4BfFNBwSYYJ","ZPLjameRikygaiM9B","3XfNmZkLe6o8CvECW","fJQsxtBoqymHQG6tL","LzxgEApraxMPkLTMn","Z2THpXfLYEJf3CB8p"],"keywords":["electrical field focal therapy irreversible electroporation prostate prostate cancer simulation"],"search_terms":["numerical","simulation","modeling","irreversible","electroporation","treatment","zone","focal","therapy","prostate","cancer","correlation","whole","mount","pathology","weighted","mri","sequences","scheltema","o'brien","van den bos","de bruin","davalos","van den geld","laguna","neal","varkarakis","skolarikos","stricker","de reijke","arena","de la rosette"],"title":"Numerical simulation modeling of the irreversible electroporation treatment zone for focal therapy of prostate cancer, correlation with whole-mount pathology and T2-weighted MRI sequences","year":2019}