Long-term survival after percutaneous irreversible electroporation of inoperable colorectal liver metastases. Schicho, A., Niessen, C., Haimerl, M., Wiesinger, I., Stroszczynski, C., Beyer, L., P., & Wiggermann, P. Cancer Management and Research, Volume 11:317-322, 12, 2018. ![Long-term survival after percutaneous irreversible electroporation of inoperable colorectal liver metastases [link]](https://bibbase.org/img/filetypes/link.svg "link")
Website abstract bibtex Background For colorectal liver metastases (CRLM) that are not amenable to surgery or thermal ablation, irreversible electroporation (IRE) is a novel local treatment modality and additional option. Methods This study is a retrospective long-term follow-up of patients with CRLM who underwent IRE as salvage treatment. Results Of the 24 included patients, 18 (75.0%) were male, and the median age was 57 (range: 28-75) years. The mean time elapsed from diagnosis to IRE was 37.9±37.3 months. Mean overall survival was 26.5 months after IRE (range: 2.5-69.2 months) and 58.1 months after diagnosis (range: 14.8-180.1 months). One-, three-, and five-year survival rates after initial diagnosis were 100.0%, 79.2%, and 41.2%; after IRE, the respective survival rates were 79.1%, 25.0%, and 8.3%. There were no statistically significant differences detected in survival after IRE with respect to gender, age, T- or N-stage at the time of diagnosis, size of metastases subject to IRE, number of hepatic lesions, or time elapsed between IRE and diagnosis. Conclusion For nonresectable CRLM, long-term survival data emphasize the value of IRE as a new minimally invasive local therapeutic approach in multimodal palliative treatment, which is currently limited to systemic or regional therapies in this setting.
@article{
title = {Long-term survival after percutaneous irreversible electroporation of inoperable colorectal liver metastases},
type = {article},
year = {2018},
identifiers = {[object Object]},
keywords = {CRLM,colorectal cancer,irreversible electroporation,liver metastases,long-term,salvage treatment,survival},
pages = {317-322},
volume = {Volume 11},
websites = {http://www.ncbi.nlm.nih.gov/pubmed/30643457,http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC6312065,https://www.dovepress.com/long-term-survival-after-percutaneous-irreversible-electroporation-of--peer-reviewed-article-CMAR},
month = {12},
id = {2464ecf7-d28c-30dd-868d-e1b779486ad6},
created = {2019-01-23T11:41:00.171Z},
accessed = {2019-01-23},
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last_modified = {2019-01-23T11:41:00.171Z},
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abstract = {Background For colorectal liver metastases (CRLM) that are not amenable to surgery or thermal ablation, irreversible electroporation (IRE) is a novel local treatment modality and additional option. Methods This study is a retrospective long-term follow-up of patients with CRLM who underwent IRE as salvage treatment. Results Of the 24 included patients, 18 (75.0%) were male, and the median age was 57 (range: 28-75) years. The mean time elapsed from diagnosis to IRE was 37.9±37.3 months. Mean overall survival was 26.5 months after IRE (range: 2.5-69.2 months) and 58.1 months after diagnosis (range: 14.8-180.1 months). One-, three-, and five-year survival rates after initial diagnosis were 100.0%, 79.2%, and 41.2%; after IRE, the respective survival rates were 79.1%, 25.0%, and 8.3%. There were no statistically significant differences detected in survival after IRE with respect to gender, age, T- or N-stage at the time of diagnosis, size of metastases subject to IRE, number of hepatic lesions, or time elapsed between IRE and diagnosis. Conclusion For nonresectable CRLM, long-term survival data emphasize the value of IRE as a new minimally invasive local therapeutic approach in multimodal palliative treatment, which is currently limited to systemic or regional therapies in this setting.},
bibtype = {article},
author = {Schicho, Andreas and Niessen, Christoph and Haimerl, Michael and Wiesinger, Isabel and Stroszczynski, Christian and Beyer, Lukas P and Wiggermann, Philipp},
journal = {Cancer Management and Research}
}
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Methods This study is a retrospective long-term follow-up of patients with CRLM who underwent IRE as salvage treatment. Results Of the 24 included patients, 18 (75.0%) were male, and the median age was 57 (range: 28-75) years. The mean time elapsed from diagnosis to IRE was 37.9±37.3 months. Mean overall survival was 26.5 months after IRE (range: 2.5-69.2 months) and 58.1 months after diagnosis (range: 14.8-180.1 months). One-, three-, and five-year survival rates after initial diagnosis were 100.0%, 79.2%, and 41.2%; after IRE, the respective survival rates were 79.1%, 25.0%, and 8.3%. There were no statistically significant differences detected in survival after IRE with respect to gender, age, T- or N-stage at the time of diagnosis, size of metastases subject to IRE, number of hepatic lesions, or time elapsed between IRE and diagnosis. Conclusion For nonresectable CRLM, long-term survival data emphasize the value of IRE as a new minimally invasive local therapeutic approach in multimodal palliative treatment, which is currently limited to systemic or regional therapies in this setting.","bibtype":"article","author":"Schicho, Andreas and Niessen, Christoph and Haimerl, Michael and Wiesinger, Isabel and Stroszczynski, Christian and Beyer, Lukas P and Wiggermann, Philipp","journal":"Cancer Management and Research","bibtex":"@article{\n title = {Long-term survival after percutaneous irreversible electroporation of inoperable colorectal liver metastases},\n type = {article},\n year = {2018},\n identifiers = {[object Object]},\n keywords = {CRLM,colorectal cancer,irreversible electroporation,liver metastases,long-term,salvage treatment,survival},\n pages = {317-322},\n volume = {Volume 11},\n websites = {http://www.ncbi.nlm.nih.gov/pubmed/30643457,http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC6312065,https://www.dovepress.com/long-term-survival-after-percutaneous-irreversible-electroporation-of--peer-reviewed-article-CMAR},\n month = {12},\n id = {2464ecf7-d28c-30dd-868d-e1b779486ad6},\n created = {2019-01-23T11:41:00.171Z},\n accessed = {2019-01-23},\n file_attached = {false},\n profile_id = {b63e8b24-ed73-38a0-835d-fc93fa76b2df},\n group_id = {7cefe685-317a-3d95-8344-b52e9a2517ff},\n last_modified = {2019-01-23T11:41:00.171Z},\n read = {false},\n starred = {false},\n authored = {false},\n confirmed = {false},\n hidden = {false},\n private_publication = {false},\n abstract = {Background For colorectal liver metastases (CRLM) that are not amenable to surgery or thermal ablation, irreversible electroporation (IRE) is a novel local treatment modality and additional option. Methods This study is a retrospective long-term follow-up of patients with CRLM who underwent IRE as salvage treatment. Results Of the 24 included patients, 18 (75.0%) were male, and the median age was 57 (range: 28-75) years. The mean time elapsed from diagnosis to IRE was 37.9±37.3 months. Mean overall survival was 26.5 months after IRE (range: 2.5-69.2 months) and 58.1 months after diagnosis (range: 14.8-180.1 months). One-, three-, and five-year survival rates after initial diagnosis were 100.0%, 79.2%, and 41.2%; after IRE, the respective survival rates were 79.1%, 25.0%, and 8.3%. There were no statistically significant differences detected in survival after IRE with respect to gender, age, T- or N-stage at the time of diagnosis, size of metastases subject to IRE, number of hepatic lesions, or time elapsed between IRE and diagnosis. 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